2. Gene
  3. PLXNA2 - plexin A2 Gene

PLXNA2 - plexin A2 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：丛素 A2

种属: Homo sapiens

同用名: OCT; PLXN2

基因 ID: 5362 | 基因类型: protein coding

关于 PLXNA2

Cytogenetic location: 1q32.2 Genomic coordinates (GRCh38): 1:208,022,242-208,244,384 (from NCBI)

This gene has 6 transcripts (splice variants), 268 orthologues and 8 paralogues. Ubiquitous expression in ovary (RPKM 8.4), lung (RPKM 6.9) and 23 other tissues.

功能概要

该基因编码 plexin-A 信号蛋白共受体家族的成员。信号蛋白是一大类分泌或膜结合蛋白，在神经系统发育过程中介导对轴突寻路的排斥作用。信号蛋白的一个子集被 plexin-A/neuropilin 跨膜受体复合物识别，触发导致轴突排斥的细胞信号转导级联。该 plexin-A 家族成员被认为可转导信号素 3A 和 -3C 的信号。[RefSeq 提供，2008 年 7 月]

This gene encodes a member of the plexin-A family of semaphorin co-receptors. Semaphorins are a large family of secreted or membrane-bound proteins that mediate repulsive effects on axon pathfinding during nervous system development. A subset of semaphorins are recognized by plexin-A/neuropilin transmembrane receptor complexes, triggering a cellular signal transduction cascade that leads to axon repulsion. This plexin-A family member is thought to transduce signals from semaphorin-3A and -3C. [provided by RefSeq, Jul 2008]

PLXNA2 基因产物(1)

mRNA Protein Name
NM_025179.4 NP_079455.3 plexin-A2 precursor
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
12372285 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

PLXNA2 蛋白结构

Sema

Sema: Sema domain (50 - 489)

PSI

PSI: Plexin repeat (510 - 559)

PSI

PSI: Plexin repeat (655 - 702)

PSI

PSI: Plexin repeat (804 - 855)

TIG

TIG: IPT/TIG domain (858 - 950)

TIG

TIG: IPT/TIG domain (954 - 1037)

TIG

TIG: IPT/TIG domain (1041 - 1108)

TIG

TIG: IPT/TIG domain (1145 - 1222)

Plexin_cytopl

Plexin_cytopl: Plexin cytoplasmic RasGAP domain (1310 - 1863)

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  • 1894 a.a.
蛋白主名 其他名称

plexin-A2

plexin 2

PLXNA2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属间
PLXNA2 O75051 Fyn Mus musculus P39688
Anti Tag CoIP
12372285
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Tetralogy Of Fallot

TOF

Fallot Tetralogy

Ventricular Septal Defect With Pulmonary Stenosis Or Atresia, Dextraposition Of Aorta, And Hypertrophy Of Right Ventricle

Tetrad Of Fallot

Fallot Tetrad

Fallot Disease

Fallot Complex

Subpulmonic Stenosis, Ventricular Septal Defect, Overriding Aorta, And Right Ventricular Hypertrophy

Interventricular Septal Defect With Dextroposition Of Aorta, Pulmonary Stenosis And Hypertrophy Of Right Ventricle

Interventricular Septal Defect, In Tetralogy Of Fallot

Ventricular Septal Defect With Obstructed Right Ventricular Outflow

Tof - [Tetralogy Of Fallot]

Pulmonary Atresia With Ventricular Septal Defect [Fallot Type]

Pulmonary Atresia, Ventricular Septal Defect And Mapcas

Pulmonary Atresia With Ventricular Septal Defect And Systemic-To-Pulmonary Collateral Arteries [Fallot Type]
Schizophrenia

SCZD

Schizophrenia With Or Without An Affective Disorder

Schizophrenia 12

Schizophrenia, Susceptibility To

Schizophrenia-1

Dementia Praecox

Schizophrenia 1
Autism Spectrum Disorder

Asd

Autism Spectrum Disorders

Autistic Continuum

Pervasive Developmental Disorder

Pervasive Development Disorder

Autistic Behavior

Autistic Disorder

Autistic

Autistic Disorder Of Childhood Onset

Infantile Autism

Childhood Autism

Kanner Syndrome

Pervasive Developmental Delay Nos

Pervasive Developmental Disorder, Not Otherwise Specified
Double Outlet Right Ventricle

Double Outlet Right Ventricle With Subpulmonary Ventricular Septal Defect

Taussig-Bing Syndrome

Dextrotransposition Of Aorta

Taussig-Bing Syndrome Or Defect

Dorv

Dorv With Subpulmonary Vsd

Dorv-Tga

Double Outlet Right Ventricle With Transposition Of The Great Arteries

Double Outlet Right Ventricle With Subpulmonary Interventricular Communication, Transposition Type

Taussig-Bing Heart

Taussig-Bing Malformation

Taussig-Bing Complex

Taussig-Bing Defect

Taussig-Bing

Double Outlet Right Ventricle With Remote Ventricular Septal Defect

Double Outlet Right Ventricle With Uncommitted Ventricular Septal Defect

Double Outlet Right Ventricle With Non-Committed Interventricular Communication

Double Outlet Right Ventricle With Subaortic Or Doubly Committed Interventricular Communication Without Pulmonary Stenosis

Double Outlet Right Ventricle With Subaortic Or Doubly Committed Interventricular Communication And Pulmonary Stenosis
Autism

Autistic Disorder

Autism Susceptibility 1

Childhood Autism

Autistic Disorder Of Childhood Onset

Infantile Autism

Kanner'S Syndrome

Autistic
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS10749 PLXNA2 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta PLXNA2 VGNC VGNC:76184
Mus musculus PLXNA2 MGD MGI:107684
Felis catus PLXNA2 VGNC VGNC:68916
Bos taurus PLXNA2 VGNC VGNC:58398
Canis familiaris PLXNA2 VGNC VGNC:44719
Rattus norvegicus PLXNA2 RGD RGD:1305325
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