POLB - DNA polymerase beta Gene

中文名称：DNA 聚合酶β

种属: Homo sapiens

基因 ID: 5423 | 基因类型: protein coding

关于 POLB

Cytogenetic location: 8p11.21 Genomic coordinates (GRCh38): 8:42,338,494-42,371,808 (from NCBI)

This gene has 17 transcripts (splice variants), 206 orthologues and 3 paralogues. Broad expression in testis (RPKM 24.2), urinary bladder (RPKM 8.5) and 24 other tissues.

功能概要

由该基因编码的蛋白质是参与碱基切除和修复的 DNA 聚合酶，也称为缺口填充 DNA 合成。编码的蛋白质作为单体，通常存在于细胞质中，但在 DNA 损伤时会转移到细胞核。存在该基因的多个转录本变体，但迄今为止仅描述了一个的全长性质。[RefSeq 提供，2011 年 9 月]

The protein encoded by this gene is a DNA Polymerase involved in base excision and repair, also called gap-filling DNA synthesis. The encoded protein, acting as a monomer, is normally found in the cytoplasm, but it translocates to the nucleus upon DNA damage. Several transcript variants of this gene exist, but the full-length nature of only one has been described to date. [provided by RefSeq, Sep 2011]

POLB 基因产物(1)

mRNA	Protein	Name
NM_002690.3	NP_002681.1	DNA polymerase beta

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables 5'-deoxyribose-5-phosphate lyase activity	IDA IDA: 通过直接分析推断	9614142	GOA
enables DNA-directed DNA polymerase activity	IDA IDA: 通过直接分析推断	9207062	GOA
enables class I DNA-(apurinic or apyrimidinic site) endonuclease activity	IDA IDA: 通过直接分析推断	9614142	GOA
enables enzyme binding	IPI IPI: 通过物理相互作用推断	16600869	GOA
enables lyase activity	IDA IDA: 通过直接分析推断	16600869	GOA
enables microtubule binding	IDA IDA: 通过直接分析推断	15725623	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	9207062	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in DNA damage response	IMP IMP: 通过突变表型推断	21362556	GOA
involved in base-excision repair	IDA IDA: 通过直接分析推断	16600869	GOA
involved in base-excision repair	IMP IMP: 通过突变表型推断	21362556	GOA
NOT involved in nucleotide-excision repair, DNA gap filling	IMP IMP: 通过突变表型推断	20227374	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in cytoplasm	IDA IDA: 通过直接分析推断	15725623	GOA
located in microtubule	IDA IDA: 通过直接分析推断	15725623	GOA
located in nucleus	IDA IDA: 通过直接分析推断	19713937	GOA
part of protein-containing complex	IDA IDA: 通过直接分析推断	25378300	GOA
located in spindle microtubule	IDA IDA: 通过直接分析推断	15725623	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

POLB 蛋白结构

HHH_8

DNA_pol_lambd_f

DNA_pol_B_palm

DNA_pol_B_thumb

0
100
200
300
335 a.a.

蛋白主名

其他名称

DNA polymerase beta

DNA pol beta

POLB 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	POLB	P06746	TPP2	Homo sapiens	P29144	Validated Y2H	25910212
种属内	POLB	P06746	TPP2	Homo sapiens	P29144	Y2H Array	31515488
种属内	POLB	P06746	TPP2	Homo sapiens	P29144	Y2H Bait-Prey Pool	25910212
种属内	POLB	P06746	TPP2	Homo sapiens	P29144	Y2H Array	25910212
种属内	POLB	P06746	TPP2	Homo sapiens	P29144	Validated Y2H	25416956
种属内	POLB	P06746	TAF1D	Homo sapiens	Q9H5J8	Anti Tag CoIP	15520167
种属内	POLB	P06746	XRCC1	Homo sapiens	P18887	Anti Tag CoIP	33961781
种属内	POLB	P06746	XRCC1	Homo sapiens	P18887	Anti Tag CoIP	28514442

种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 POLB 蛋白

目录号	产品名	蛋白编号	纯度
HY-P7883	DNA polymerase beta Protein, Human (His)	P06746 (S2-E335)	≥95%

关联疾病

疾病名称

别名

Werner Syndrome

Werner'S Syndrome	WRN
Adult Progeria	Ws
Adult Premature Ageing Syndrome	Adult Premature Aging Syndrome
Werners Syndrome

Colorectal Cancer

Colon Cancer	Colorectal Carcinoma
Colon Carcinoma	Colorectal Cancer, Susceptibility To
Carcinoma Of Colon	CRC
Colorectal Cancer With Chromosomal Instability, Somatic	Colon Cancer, Somatic
Colon Cancer, Susceptibility To	Colonic Neoplasms
Colorectal Neoplasms	Colorectal Cancer, Somatic
Colon Cancer, Advanced, Somatic	Colonic Carcinoma
Colorectal Carcinomas	Colon Cancers
Colorectal Cancers	Cancer, Colorectal, Somatic
Cancer, Colon	Cancer, Colorectal, Susceptibility To
Colorectal Neoplasm	Colonic Neoplasm
Malignant Tumor Of Colon

Male Infertility

Infertility, Male	Infertility Male
Male Sterility	Absolute Infertility

Fanconi Anemia, Complementation Group A

Fanconi Anemia	Fanconi Pancytopenia
Fanconi Anemia Complementation Group A	FANCA
Fa	Fanconi Panmyelopathy
Fanconi'S Anemia	Fanconi Anaemia
Fanconi'S Anaemia	Fanconi Hypoplastic Anemia
Estren-Dameshek Variant Of Fanconi Anemia	Estren-Dameshek Variant Of Fanconi Pancytopenia
Fanconi Anemia Estren-Dameshek Variant	Fanconis Anemia

Xeroderma Pigmentosum, Variant Type

Xeroderma Pigmentosum	XPV
Xeroderma Pigmentosum Variant Type	Xeroderma Pigmentosum With Normal Dna Repair Rates
Photosensitivity With Defective Dna Synthesis	Xp
De Sanctis-Cacchione Syndrome	Desanctis-Cacchione Syndrome
Xeroderma Pigmentosa	Xerodermic Idiocy
Xeroderma Pigmentosum Variant	Xp - [Xeroderma Pigmentosum]
Atrophoderma Pigmentosum

Rhabdomyosarcoma

Immune Deficiency Disease

Immunodeficiency	Primary Immunodeficiency
Primary Immunodeficiency Disease	Immunologic Deficiency Syndromes
Hypoimmunity	Immune Deficiency Disorder
Immunodeficiency Syndrome	Immune Disorder
Primary Immune Deficiency Disorder	Immune System Diseases
Human Immunodeficiency Virus Infection	Hiv - [Human Immunodeficiency Virus Infection]
Hiv Positive Nos	Hiv Disease
Acquired Immune Deficiency Syndrome-Related Complex	Aids-Like Syndrome
Aids-Related Complex Nos	Arc - [Aids-Related Complex]
Immunodeficiency Due To Human Immunodeficiency Virus Infection	Unspecified Human Immunodeficiency Virus Disease
Hiv Disease Nos	Human Immunodeficiency Virus Positive Nos
Hiv Nos	Deficiency Of Complement Initial Pathway
Deficiency Of Complement Terminal Pathway	Cfdd - [Complement Factor D Deficiency]
Immunodeficiency With Nk-Cell - [Natural-Killer Cell] Deficiency	Nonfamilial Hypogammaglobulinaemia
Common Variable Immune Deficiency	Nonfamilial Agammaglobulinaemia
Common Variable Agammaglobulinaemia	Agammaglobulinaemia Nos
Agammaglobulinaemia Antibody Deficiency Syndrome	Hypogammaglobulinaemia Antibody Deficiency Syndrome
Acquired Agammaglobulinaemia Nos	Hypogammaglobulinaemia Nos
Hyper Igm

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS10818	POLB Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Rattus norvegicus	POLB	RGD	RGD:3363
Mus musculus	POLB	MGD	MGI:97740
Felis catus	POLB	VGNC	VGNC:68935
Macaca mulatta	POLB	VGNC	VGNC:104470
Canis familiaris	POLB	VGNC	VGNC:44773
Bos taurus	POLB	VGNC	VGNC:33112
Others	POLB	NCBI

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站点地图隐私声明

沪ICP备15051369号-4

上海工商

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沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

POLB - DNA polymerase beta Gene

关于 POLB

功能概要

POLB 基因产物(1)

POLB 蛋白结构

POLB 蛋白互作信息

重组 POLB 蛋白

关联疾病

直系同源

热门区域

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POLB - DNA polymerase beta Gene

关于 POLB

功能概要

POLB 基因产物(1)

POLB 蛋白结构

POLB 蛋白互作信息

重组 POLB 蛋白

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z