OTUD4 - OTU deubiquitinase 4 Gene

中文名称：OTU 去泛素化酶 4

种属: Homo sapiens

同用名: HIN1; DUBA6; HSHIN1

基因 ID: 54726 | 基因类型: protein coding

关于 OTUD4

Cytogenetic location: 4q31.21 Genomic coordinates (GRCh38): 4:145,133,650-145,180,589 (from NCBI)

This gene has 10 transcripts (splice variants), 146 orthologues and 5 paralogues. Ubiquitous expression in testis (RPKM 19.7), bone marrow (RPKM 11.0) and 25 other tissues.

功能概要

已发现该基因的可变剪接转录物变体。由较短的转录变体编码的较小的蛋白质亚型仅在 HIV-1 感染的细胞中发现。[RefSeq 提供，2010 年 7 月]

Alternatively spliced transcript variants have been found for this gene. The smaller protein isoform encoded by the shorter transcript variant is found only in HIV-1 infected cells. [provided by RefSeq, Jul 2010]

OTUD4 基因产物(4)

mRNA	Protein	Name
NM_001102653.1	NP_001096123.1	OTU domain-containing protein 4 isoform 3
NM_001366057.1	NP_001352986.1	OTU domain-containing protein 4 isoform 4
NM_001366058.1	NP_001352987.1	OTU domain-containing protein 4 isoform 5
NM_017493.7	NP_059963.1	OTU domain-containing protein 4 isoform 2

基因本体论

分子功能
生物过程

分子功能 GO 注释	逻辑证据	参考文献	来源
enables K63-linked deubiquitinase activity	IDA IDA: 通过直接分析推断	29395066	GOA
enables cysteine-type deubiquitinase activity	IDA IDA: 通过直接分析推断	23827681	GOA
enables molecular adaptor activity	IDA IDA: 通过直接分析推断	25944111	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	25416956	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in DNA alkylation repair	IDA IDA: 通过直接分析推断	25944111	GOA
involved in negative regulation of interleukin-1-mediated signaling pathway	IDA IDA: 通过直接分析推断	29395066	GOA
involved in negative regulation of toll-like receptor signaling pathway	IDA IDA: 通过直接分析推断	29395066	GOA
involved in protein K11-linked deubiquitination	IDA IDA: 通过直接分析推断	36943869	GOA
involved in protein K48-linked deubiquitination	IDA IDA: 通过直接分析推断	23827681	GOA
involved in protein K63-linked deubiquitination	IDA IDA: 通过直接分析推断	29395066	GOA
involved in regulation of protein K48-linked deubiquitination	IDA IDA: 通过直接分析推断	25944111	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

OTUD4 蛋白结构

OTU

0
200
400
600
800
1000
1114 a.a.

蛋白主名

其他名称

OTU domain-containing protein 4

HIV-1 induced protein HIN-1

OTUD4 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
Intra	OTUD4	Q01804	STAT1	Homo sapiens	P42224	Validated Y2H	25416956
Intra	OTUD4	Q01804	VDR	Homo sapiens	P11473-2	Y2H Array	32296183
Intra	OTUD4	Q01804	VDR	Homo sapiens	P11473-2	Y2H Prey Pooling	32296183
Intra	OTUD4	Q01804	REL	Homo sapiens	Q04864	Y2H Prey Pooling	25416956
Intra	OTUD4	Q01804	REL	Homo sapiens	Q04864	Y2H Array	25416956
Intra	OTUD4	Q01804	REL	Homo sapiens	Q04864	Validated Y2H	25416956
Intra	OTUD4	Q01804	EXOSC8	Homo sapiens	Q96B26	Validated Y2H	32296183
Intra	OTUD4	Q01804	EXOSC8	Homo sapiens	Q96B26	Y2H Prey Pooling	32296183
Intra	OTUD4	Q01804	EXOSC8	Homo sapiens	Q96B26	Y2H Array	32296183
Intra	OTUD4	Q01804	TCF4	Homo sapiens	P15884	Y2H Array	25416956
Intra	OTUD4	Q01804	TCF4	Homo sapiens	P15884	Y2H Prey Pooling	25416956
Intra	OTUD4	Q01804	ZNF655	Homo sapiens	Q8N720	Y2H Prey Pooling	32296183
Intra	OTUD4	Q01804	ZNF655	Homo sapiens	Q8N720	Validated Y2H	32296183
Intra	OTUD4	Q01804	ZNF655	Homo sapiens	Q8N720	Y2H Array	32296183

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Boucher-Neuhauser Syndrome

Ataxia-Hypogonadism-Choroidal Dystrophy Syndrome	BNHS
Spinocerebellar Ataxia, Hypogonadotropic Hypogonadism, And Chorioretinal Dystrophy	Boucher-Neuhäuser Syndrome
Chorioretinal Dystrophy, Spinocerebellar Ataxia, And Hypogonadotropic Hypogonadism	Ataxia - Hypogonadism - Choroidal Dystrophy
Chorioretinal Dystrophy, Spinocerebellar Ataxia And Hypogonadotropic Hypogonadism	Bns
Cerebellar Ataxia With Hypogonadism And Choroidal Dystrophy Syndrome	Boucher Neuhauser Syndrome

Gordon Holmes Syndrome

Cerebellar Ataxia And Hypogonadotropic Hypogonadism	Lhrh Deficiency And Ataxia
Cerebellar Ataxia-Hypogonadism Syndrome	GDHS
Cahh	Luteinizing Hormone-Releasing Hormone Deficiency With Ataxia
Gordon-Holmes Syndrome	Deficiency Of Luteinizing Hormone-Releasing Hormone With Ataxia
Luteinizing Hormone-Releasing Hormone, Deficiency Of, With Ataxia	Cerebellar Ataxia - Hypogonadism
Luteinizing Hormone Releasing Hormone, Deficiency Of With Ataxia	Ataxia, Cerebellar, And Hypogonadotropic Hypogonadism

Nivelon-Nivelon-Mabille Syndrome

Chondrodysplasia-Pseudohermaphroditism Syndrome	NNMS
Chondrodysplasia-Disorder Of Sex Development Syndrome	Nivelon Nivelon Mabille Syndrome

Spinocerebellar Ataxia, Autosomal Recessive 16

Autosomal Recessive Spinocerebellar Ataxia 16	SCAR16
Autosomal Recessive Cerebellar Ataxia Due To Stub1 Deficiency	Spinocerebellar Ataxia Autosomal Recessive Type 16
Spinocerebellar Ataxia, Autosomal Recessive, 16	Ataxia, Spinocerebellar, Autosomal Recessive, Type 16

Spinocerebellar Ataxia, Autosomal Recessive 24

SCAR24	Autosomal Recessive Spinocerebellar Ataxia 24
Spinocerebellar Ataxia, Autosomal Recessive, 24	Ataxia, Spinocerebellar, Autosomal Recessive, Type 24

Kallmann Syndrome

Hypogonadism With Anosmia	Kallman'S Syndrome
Anosmic Hypogonadism	Anosmic Idiopathic Hypogonadotropic Hypogonadism
Hypogonadotropic Hypogonadism And Anosmia	Hypogonadotropic Hypogonadism-Anosmia Syndrome
Olfacto-Genital Pathological Sequence	Familial Hypogonadism With Anosmia
Kallman Syndrome	Dysplasia Olfactogenitalis Of De Morsier
Kallmann'S Syndrome	Congenital Hypogonadotropic Hypogonadism With Anosmia

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-161774	ST80	Inhibitor	/	否
HY-RS09873	OTUD4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Macaca mulatta	OTUD4	VGNC	VGNC:75675
Mus musculus	OTUD4	MGD	MGI:1098801
Felis catus	OTUD4	VGNC	VGNC:64000
Rattus norvegicus	OTUD4	RGD	RGD:1305606
Bos taurus	OTUD4	VGNC	VGNC:32495
Canis familiaris	OTUD4	VGNC	VGNC:44186

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