2. Gene
  3. LEPROT - leptin receptor overlapping transcript Gene

LEPROT - leptin receptor overlapping transcript Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：瘦素受体重叠转录本

种属: Homo sapiens

同用名: LEPR; VPS55; OBRGRP; OB-RGRP

基因 ID: 54741 | 基因类型: protein coding

关于 LEPROT

Cytogenetic location: 1p31.3 Genomic coordinates (GRCh38): 1:65,420,668-65,436,007 (from NCBI)

This gene has 6 transcripts (splice variants), 210 orthologues and 1 paralogue. Ubiquitous expression in fat (RPKM 33.5), kidney (RPKM 30.3) and 25 other tissues.

功能概要

LEPROT 与高尔基复合体和核内体相关，并在生长激素受体 (GHR；MIM 600946) 和瘦素受体 (OBR 或 LEPR；MIM 601007) 的细胞表面表达中发挥作用，从而改变受体介导的细胞信号传导 (Couturier 等人) al., 2007 [PubMed 18042720]；Touvier 等人，2009 [PubMed 19907080]) .[OMIM 提供，2010 年 7 月]

LEPROT is associated with the Golgi complex and endosomes and has a role in cell surface expression of growth hormone receptor (GHR; MIM 600946) and Leptin receptor (OBR, or LEPR; MIM 601007), thereby altering receptor-mediated cell signaling (Couturier et al., 2007 [PubMed 18042720]; Touvier et al., 2009 [PubMed 19907080]).[supplied by OMIM, Jul 2010]

LEPROT 基因产物(3)

mRNA Protein Name
NM_001198681.2 NP_001185610.1 leptin receptor gene-related protein isoform 2
NM_001198683.2 NP_001185612.1 leptin receptor gene-related protein isoform 3
NM_017526.5 NP_059996.1 leptin receptor gene-related protein isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
18042720 GOA
enables signaling receptor binding IDA
IDA: 通过直接分析推断
18042720 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in negative regulation of growth hormone receptor signaling pathway IDA
IDA: 通过直接分析推断
19907080 GOA
involved in negative regulation of protein localization to cell surface IDA
IDA: 通过直接分析推断
18042720 GOA
involved in negative regulation of receptor signaling pathway via JAK-STAT IDA
IDA: 通过直接分析推断
18042720 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in Golgi apparatus IDA
IDA: 通过直接分析推断
18042720 GOA
located in endosome IDA
IDA: 通过直接分析推断
18042720 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

LEPROT 蛋白结构

Vps55

Vps55: Vacuolar protein sorting 55 (7 - 125)

  • 0
  • 100
  • 131 a.a.
蛋白主名 其他名称

leptin receptor gene-related protein

DnaJ (Hsp40) homolog, subfamily C, member 6

LEPROT 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra LEPROT O15243 SYNGR1 Homo sapiens O43759-2
Validated Y2H
32296183
Intra LEPROT O15243 TMEM50B Homo sapiens P56557
Validated Y2H
32296183
Intra LEPROT O15243 TMEM50B Homo sapiens P56557
Y2H Array
32296183
Intra LEPROT O15243 TMEM50A Homo sapiens O95807
Validated Y2H
32296183
Intra LEPROT O15243 AQP6 Homo sapiens Q13520
Validated Y2H
32296183
Intra LEPROT O15243 AQP6 Homo sapiens Q13520
Y2H Array
32296183
Intra LEPROT O15243 AQP6 Homo sapiens Q13520
Y2H Prey Pooling
32296183
Intra LEPROT O15243 RHCG Homo sapiens Q9UBD6
Y2H Prey Pooling
32296183
Intra LEPROT O15243 RHCG Homo sapiens Q9UBD6
Y2H Array
32296183
Intra LEPROT O15243 RHCG Homo sapiens Q9UBD6
Validated Y2H
32296183
Intra LEPROT O15243 PLPPR1 Homo sapiens Q8TBJ4
Y2H Prey Pooling
32296183
Intra LEPROT O15243 PLPPR1 Homo sapiens Q8TBJ4
Validated Y2H
32296183
Intra LEPROT O15243 PLPPR1 Homo sapiens Q8TBJ4
Y2H Array
32296183
Intra LEPROT O15243 SLC7A1 Homo sapiens P30825
Validated Y2H
32296183
Intra LEPROT O15243 SLC7A1 Homo sapiens P30825
Y2H Array
32296183
Intra LEPROT O15243 SLC7A1 Homo sapiens P30825
Y2H Prey Pooling
32296183
Intra LEPROT O15243 TMX2 Homo sapiens Q9Y320
Y2H Prey Pooling
32296183
Intra LEPROT O15243 TMX2 Homo sapiens Q9Y320
Validated Y2H
32296183
Intra LEPROT O15243 TMX2 Homo sapiens Q9Y320
Y2H Array
32296183
Intra LEPROT O15243 TMEM120A Homo sapiens Q9BXJ8
Validated Y2H
32296183
Intra LEPROT O15243 GJA5 Homo sapiens P36382
Y2H Array
32296183
Intra LEPROT O15243 GJA5 Homo sapiens P36382
Y2H Prey Pooling
32296183
Intra LEPROT O15243 GJA5 Homo sapiens P36382
Validated Y2H
32296183
Intra LEPROT O15243 YIPF1 Homo sapiens Q9Y548
Validated Y2H
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Leptin Deficiency Or Dysfunction

Morbid Obesity

Obesity Due To Congenital Leptin Deficiency

LEPD

Congenital Leptin Deficiency

Obesity, Morbid

Obesity, Morbid, Due To Leptin Deficiency

Severe Obesity

Obesity, Morbid, Nonsyndromic 1

Leptin Deficiency

Obesity, Severe, Due To Leptin Deficiency

Leptin

Morbid Obesity Due To Leptin Deficiency

Obesity Morbid

Leptin Dysfunction
Body Mass Index Quantitative Trait Locus 11

OBESITY

Obesity, Susceptibility To

Leanness, Inherited

Obesity, Susceptibility To, Bmiq11

Obesity, Mild, Early-Onset

Obesity, Association With

Obesity, Early-Onset, Susceptibility To

Obesity, Severe

Obesity, Severe, And Type Ii Diabetes

Obesity, Late-Onset

Obesity , Susceptibility To

BMIQ11

Obesity Bmiq11

Obesity, Early-Onset

Simple Obesity Nos

Excess Fat

Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified

Adiposis
Acute Promyelocytic Leukemia

Leukemia, Acute Promyelocytic

Acute Myeloblastic Leukemia Type 3

Aml M3

APL

Leukemia, Acute Promyelocytic, Somatic

Aml With T(15

17)(Q22

Q12)

(Pml/Raralpha) And Variants

Apml

Acute Myeloblastic Leukemia 3

Acute Myeloid Leukemia With T(15

17)(Q22

Q12)

(Pml/Raralpha) And Variants

Acute Myeloblastic Leukaemia Type 3

Acute Myeloid Leukaemia M3

Acute Myeloid Leukemia M3

Acute Promyelocytic Leukaemia

M3 Anll

Myeloid Leukemia, Acute, M3

Leukemia Promyelocytic Acute

Leukemia, Promyelocytic, Acute

Leukemia, Acute, Promyelocytic
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS07595 LEPROT Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus LEPROT VGNC VGNC:30844
Macaca mulatta LEPROT VGNC VGNC:74158
Mus musculus LEPROT MGD MGI:2687005
Canis familiaris LEPROT VGNC VGNC:42639
Rattus norvegicus LEPROT RGD RGD:621034
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z