PPM1A - protein phosphatase, Mg2+/Mn2+ dependent 1A Gene

中文名称：蛋白磷酸酶，Mg2+/Mn2+ 依赖性 1A

种属: Homo sapiens

同用名: PP2CA; PP2Calpha; PP2C-ALPHA

关于 PPM1A

功能概要

该基因编码的蛋白质是 Ser/Thr 蛋白磷酸酶 PP2C 家族的成员。已知 PP2C 家族成员是细胞应激反应途径的负调节剂。该磷酸酶使 MAP 激酶和 MAP 激酶激酶去磷酸化并负向调节其活性。它已被证明可以抑制由环境压力诱导的 p38 和 JNK 激酶级联反应的激活。这种磷酸酶还可以使细胞周期蛋白依赖性激酶去磷酸化，因此可能参与细胞周期控制。据报道，这种磷酸酶的过表达会激活肿瘤抑制基因 TP53/p53 的表达，从而导致 G2/M 细胞周期停滞和细胞凋亡。已经描述了编码不同同种型的三种可变剪接的转录物变体。[RefSeq 提供，2008 年 7 月]

The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This Phosphatase dephosphorylates, and negatively regulates the activities of, MAP kinases and MAP kinase kinases. It has been shown to inhibit the activation of p38 and JNK kinase cascades induced by environmental stresses. This Phosphatase can also dephosphorylate cyclin-dependent kinases, and thus may be involved in cell cycle control. Overexpression of this Phosphatase is reported to activate the expression of the tumor suppressor gene TP53/p53, which leads to G2/M cell cycle arrest and Apoptosis. Three alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]