ENOX1 - ecto-NOX disulfide-thiol exchanger 1 Gene

中文名称：ecto-NOX 二硫化物-硫醇交换器 1

种属: Homo sapiens

同用名: CNOX; PIG38; cCNOX; bA64J21.1

基因 ID: 55068 | 基因类型: protein coding

关于 ENOX1

Cytogenetic location: 13q14.11 Genomic coordinates (GRCh38): 13:43,213,130-43,786,972 (from NCBI)

This gene has 3 transcripts (splice variants), 205 orthologues and 1 paralogue. Broad expression in testis (RPKM 1.9), brain (RPKM 1.3) and 19 other tissues.

功能概要

该基因编码的蛋白质参与质膜电子传递途径。编码的蛋白质具有对苯二酚 (NADH) 氧化酶活性和蛋白质二硫化物-硫醇交换活性。这两项活动以 24 分钟为周期循环，一项活动处于高峰期，另一项活动处于最低点。[RefSeq 提供，2016 年 12 月]

The protein encoded by this gene is involved in plasma membrane electron transport pathways. The encoded protein has both a hydroquinone (NADH) oxidase activity and a protein disulfide-thiol interchange activity. The two activities cycle with a periodicity of 24 minutes, with one activity being at its peak when the Other is at its lowest. [provided by RefSeq, Dec 2016]

ENOX1 基因产物(12)

mRNA	Protein	Name
NM_001127615.3	NP_001121087.1	ecto-NOX disulfide-thiol exchanger 1 isoform b
NM_001242863.3	NP_001229792.1	ecto-NOX disulfide-thiol exchanger 1 isoform b
NM_001347963.2	NP_001334892.1	ecto-NOX disulfide-thiol exchanger 1 isoform a
NM_001347964.2	NP_001334893.1	ecto-NOX disulfide-thiol exchanger 1 isoform b
NM_001347965.2	NP_001334894.1	ecto-NOX disulfide-thiol exchanger 1 isoform b
NM_001347966.2	NP_001334895.1	ecto-NOX disulfide-thiol exchanger 1 isoform b
NM_001347967.2	NP_001334896.1	ecto-NOX disulfide-thiol exchanger 1 isoform b
NM_001347968.2	NP_001334897.1	ecto-NOX disulfide-thiol exchanger 1 isoform b
NM_001347969.2	NP_001334898.1	ecto-NOX disulfide-thiol exchanger 1 isoform b
NM_001347970.2	NP_001334899.1	ecto-NOX disulfide-thiol exchanger 1 isoform c
NM_001347971.2	NP_001334900.1	ecto-NOX disulfide-thiol exchanger 1 isoform c
NM_017993.5	NP_060463.2	ecto-NOX disulfide-thiol exchanger 1 isoform b

基因本体论

分子功能

分子功能 GO 注释	逻辑证据	参考文献	来源
enables NADH dehydrogenase activity	IDA IDA: 通过直接分析推断	19055324	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	16189514	GOA
enables protein disulfide isomerase activity	IDA IDA: 通过直接分析推断	19055324	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

ENOX1 蛋白结构

RRM_1

0
100
200
300
400
500
600
643 a.a.

蛋白主名

其他名称

ecto-NOX disulfide-thiol exchanger 1

candidate growth-related and time keeping constitutive hydroquinone (NADH) oxidase

ENOX1 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	ENOX1	Q8TC92	ENOX2	Homo sapiens	Q16206-2	Y2H Prey Pooling	25416956
种属内	ENOX1	Q8TC92	ENOX2	Homo sapiens	Q16206-2	Validated Y2H	25416956
种属内	ENOX1	Q8TC92	ENOX2	Homo sapiens	Q16206-2	Y2H Array	25416956
种属内	ENOX1	Q8TC92	TRIM43	Homo sapiens	Q96BQ3	Validated Y2H	32296183
种属内	ENOX1	Q8TC92	TRIM43	Homo sapiens	Q96BQ3	Y2H Array	25416956
种属内	ENOX1	Q8TC92	TRIM43	Homo sapiens	Q96BQ3	Y2H Prey Pooling	25416956
种属内	ENOX1	Q8TC92	SDCBP	Homo sapiens	O00560	Y2H Prey Pooling	25416956
种属内	ENOX1	Q8TC92	GORASP2	Homo sapiens	Q9H8Y8	Validated Y2H	25416956
种属内	ENOX1	Q8TC92	GORASP2	Homo sapiens	Q9H8Y8	Y2H Prey Pooling	25416956
种属内	ENOX1	Q8TC92	LNX1	Homo sapiens	Q8TBB1	Y2H Pooling	16189514
种属内	ENOX1	Q8TC92	ZMYND19	Homo sapiens	Q96E35	Validated Y2H	32296183

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Hypocalcemia, Autosomal Dominant 2

Autosomal Dominant Hypocalcemia 2	HYPOC2
Hypocalcemia, Autosomal Dominant, Type 2

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS04384	ENOX1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Canis familiaris	ENOX1	VGNC	VGNC:40371
Mus musculus	ENOX1	MGD	MGI:2444896
Bos taurus	ENOX1	VGNC	VGNC:28502
Macaca mulatta	ENOX1	VGNC	VGNC:72110
Felis catus	ENOX1	VGNC	VGNC:61869
Rattus norvegicus	ENOX1	RGD	RGD:1306118

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