1. Gene
  2. MED9 - mediator complex subunit 9 Gene

MED9 - mediator complex subunit 9 Gene

中文名称:介体复合物亚基 9

种属: Homo sapiens

同用名: MED25

基因 ID: 55090 | 基因类型: protein coding

关于 MED9

Cytogenetic location: 17p11.2 Genomic coordinates (GRCh38): 17:17,477,000-17,493,221 (from NCBI)

This gene has 5 transcripts (splice variants) and 203 orthologues. Ubiquitous expression in heart (RPKM 9.0), brain (RPKM 7.1) and 25 other tissues.

功能概要

多蛋白介质复合物是 DNA 结合转录因子激活 RNA 聚合酶 II 转录所需的共激活因子。该基因编码的蛋白质被认为是介体复合体的一个亚基。该基因位于 17 号染色体上的 Smith-Magenis 综合征区域内。[RefSeq 提供,2008 年 7 月]

The multiprotein Mediator complex is a coactivator required for activation of RNA polymerase II transcription by DNA bound transcription factors. The protein encoded by this gene is thought to be a subunit of the Mediator complex. This gene is located within the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, Jul 2008]

MED9 基因产物(1)

mRNA Protein Name
NM_018019.3 NP_060489.1 mediator of RNA polymerase II transcription subunit 9
基因本体论
  • 分子功能
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
14638676 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of core mediator complex IPI
IPI: 通过物理相互作用推断
24882805 GOA
located in nucleus IDA
IDA: 通过直接分析推断
24882805 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

MED9 蛋白结构

Med9

Med9: RNA polymerase II transcription mediator complex subunit 9 (63 - 140)

  • 0
  • 100
  • 146 a.a.
蛋白主名 其他名称

mediator of RNA polymerase II transcription subunit 9

mediator of RNA polymerase II transcription, subunit 9 homolog

MED9 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
MED9 Q9NWA0 MED4 Homo sapiens Q9NPJ6
Anti Tag CoIP
15175163
种属内
MED9 Q9NWA0 MED4 Homo sapiens Q9NPJ6
Anti Tag CoIP
14638676
种属内
MED9 Q9NWA0 MED4 Homo sapiens Q9NPJ6
Anti Tag CoIP
24882805
种属内
MED9 Q9NWA0 MED4 Homo sapiens Q9NPJ6
Anti Tag CoIP
35271311
种属内
MED9 Q9NWA0 MED4 Homo sapiens Q9NPJ6
Pull Down
14638676
种属内
MED9 Q9NWA0 MED21 Homo sapiens Q13503
Anti Tag CoIP
15175163
种属内
MED9 Q9NWA0 MED21 Homo sapiens Q13503
Anti Tag CoIP
14638676
种属内
MED9 Q9NWA0 MED21 Homo sapiens Q13503
Anti Tag CoIP
35271311
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Smith-Magenis Syndrome

SMS

Chromosome 17p11.2 Deletion Syndrome

17p11.2 Microdeletion Syndrome

17p11.2 Monosomy

Chromosome 17p Deletion Syndrome

Del(17)

P11.2

17p- Syndrome

Deletion 17p Syndrome

Partial Monosomy 17p

Jacobsen Syndrome

Chromosome 11q Deletion Syndrome

Partial 11q Monosomy Syndrome

Jacobsen Distal 11q Deletion Syndrome

JBS

11q Partial Monosomy Syndrome

Chromosome 11q Deletion

11q Deletion

11q Monosomy

Deletion 11q

Monosomy 11q

Partial Monosomy 11q

11q Deletion Disorder

11q Deletion Syndrome

11q Terminal Deletion Disorder

11q- Deletion Syndrome

11q23 Deletion Disorder

Jacobsen Thrombocytopenia

11q Terminal Deletion Syndrome

Del(11)(Q23.3)

Del(11)(Qter)

Distal Deletion 11q

Distal Monosomy 11q

Monosomy 11qter

Telomeric Deletion 11q

Paris-Trousseau Thrombocytopenia

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Canis familiaris MED9 VGNC VGNC:43142
Mus musculus MED9 MGD MGI:2183151
Felis catus MED9 VGNC VGNC:99277
Rattus norvegicus MED9 RGD RGD:1563669
Bos taurus MED9 VGNC VGNC:31370
Macaca mulatta MED9 VGNC VGNC:74577
Others MED9 NCBI