2. Gene
  3. INTS10 - integrator complex subunit 10 Gene

INTS10 - integrator complex subunit 10 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：整合复合物亚基 10

种属: Homo sapiens

同用名: INT10; C8orf35

基因 ID: 55174 | 基因类型: protein coding

关于 INTS10

Cytogenetic location: 8p21.3 Genomic coordinates (GRCh38): 8:19,817,416-19,852,067 (from NCBI)

This gene has 19 transcripts (splice variants) and 205 orthologues. Ubiquitous expression in thyroid (RPKM 19.2), prostate (RPKM 12.2) and 25 other tissues.

功能概要

INTS10 是 Integrator 复合体的一个亚基，它与 RNA 聚合酶 II 大亚基 (POLR2A; MIM 180660) 的 C 端结构域结合，并介导小核 RNA U1 (RNU1; MIM 180680) 和 U2 ( RNU2；MIM 180690) (Baillat 等人，2005 [PubMed 16239144]) 。[OMIM 提供，2008 年 3 月]

INTS10 is a subunit of the Integrator complex, which associates with the C-terminal domain of RNA polymerase II large subunit (POLR2A; MIM 180660) and mediates 3-prime end processing of small nuclear RNAs U1 (RNU1; MIM 180680) and U2 (RNU2; MIM 180690) (Baillat et al., 2005 [PubMed 16239144]).[supplied by OMIM, Mar 2008]

INTS10 基因产物(19)

mRNA Protein Name
NM_001353505.2 NP_001340434.1 integrator complex subunit 10 isoform a
NM_001353506.2 NP_001340435.1 integrator complex subunit 10 isoform b
NM_001353507.2 NP_001340436.1 integrator complex subunit 10 isoform c
NM_001353508.2 NP_001340437.1 integrator complex subunit 10 isoform d
NM_001353509.2 NP_001340438.1 integrator complex subunit 10 isoform e
NM_001353510.2 NP_001340439.1 integrator complex subunit 10 isoform f
NM_001353511.2 NP_001340440.1 integrator complex subunit 10 isoform h
NM_001353512.2 NP_001340441.1 integrator complex subunit 10 isoform i
NM_001353513.2 NP_001340442.1 integrator complex subunit 10 isoform j
NM_001353514.2 NP_001340443.1 integrator complex subunit 10 isoform k
NM_001353515.2 NP_001340444.1 integrator complex subunit 10 isoform l
NM_001353516.2 NP_001340445.1 integrator complex subunit 10 isoform m
NM_001353517.2 NP_001340446.1 integrator complex subunit 10 isoform n
NM_001353518.2 NP_001340447.1 integrator complex subunit 10 isoform n
NM_001353519.2 NP_001340448.1 integrator complex subunit 10 isoform n
NM_001353520.2 NP_001340449.1 integrator complex subunit 10 isoform o
NM_001353521.2 NP_001340450.1 integrator complex subunit 10 isoform p
NM_001353522.2 NP_001340451.1 integrator complex subunit 10 isoform p
NM_018142.4 NP_060612.2 integrator complex subunit 10 isoform g
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
contributes to protein binding IPI
IPI: 通过物理相互作用推断
16239144 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
24981860 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in snRNA processing IDA
IDA: 通过直接分析推断
16239144 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of integrator complex IDA
IDA: 通过直接分析推断
16239144 GOA
located in nucleus IDA
IDA: 通过直接分析推断
23904267 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

integrator complex subunit 10

关联疾病

疾病名称 别名
Kbg Syndrome

KBGS

Macrodontia, Mental Retardation, Characteristic Facies, Short Stature, And Skeletal Anomalies

Short Stature, Characteristic Facies, Macrodontia, Intellectual Disability, And Skeletal Anomalies

Short Stature, Characteristic Facies, Macrodontia, Mental Retardation, And Skeletal Anomalies

Short Stature-Characteristic Facies-Mental Retardation-Macrodontia-Skeletal Anomalies Syndrome

Short Stature-Facial And Skeletal Anomalies-Intellectual Disability-Macrodontia Syndrome
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS06851 INTS10 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus INTS10 VGNC VGNC:30224
Felis catus INTS10 VGNC VGNC:62938
Mus musculus INTS10 MGD MGI:1918135
Rattus norvegicus INTS10 RGD RGD:1304711
Macaca mulatta INTS10 VGNC VGNC:73653
Canis familiaris INTS10 VGNC VGNC:42046
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