1. Gene
  2. LAPTM4B - lysosomal protein transmembrane 4 beta Gene

LAPTM4B - lysosomal protein transmembrane 4 beta Gene

中文名称:溶酶体蛋白跨膜 4 beta

种属: Homo sapiens

同用名: LC27; LAPTM4beta

基因 ID: 55353 | 基因类型: protein coding

关于 LAPTM4B

Cytogenetic location: 8q22.1 Genomic coordinates (GRCh38): 8:97,775,788-97,853,013 (from NCBI)

This gene has 4 transcripts (splice variants), 288 orthologues and 2 paralogues. Ubiquitous expression in heart (RPKM 97.2), testis (RPKM 52.3) and 23 other tissues.

功能概要

启用神经酰胺结合活性;酶结合活性;和磷脂酰肌醇二磷酸结合活性。参与多个过程,包括大分子代谢过程的负调控;调节溶酶体膜通透性;和溶酶体组织的调节。位于多种细胞成分中,包括核内体;溶酶体膜;和质膜。 [由基因组资源联盟提供,2022 年 4 月]

Enables ceramide binding activity; Enzyme binding activity; and phosphatidylinositol bisphosphate binding activity. Involved in several processes, including negative regulation of macromolecule metabolic process; regulation of lysosomal membrane permeability; and regulation of lysosome organization. Located in several cellular components, including endosome; lysosomal membrane; and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

LAPTM4B 基因产物(1)

mRNA Protein Name
NM_018407.6 NP_060877.4 lysosomal-associated transmembrane protein 4B
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables ceramide binding IDA
IDA: 通过直接分析推断
26280656 GOA
enables kinase binding IPI
IPI: 通过物理相互作用推断
25588945 GOA
enables phosphatidylinositol bisphosphate binding IDA
IDA: 通过直接分析推断
25588945 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
20711237 GOA
enables ubiquitin protein ligase binding IPI
IPI: 通过物理相互作用推断
25588945 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cell projection IDA
IDA: 通过直接分析推断
22096579 GOA
located in early endosome IDA
IDA: 通过直接分析推断
25588945 GOA
located in endosome IDA
IDA: 通过直接分析推断
25588945 GOA
located in late endosome membrane IDA
IDA: 通过直接分析推断
21224396 GOA
located in lysosomal membrane IDA
IDA: 通过直接分析推断
21224396 GOA
located in lysosome IDA
IDA: 通过直接分析推断
25588945 GOA
located in multivesicular body membrane IDA
IDA: 通过直接分析推断
25588945 GOA
located in multivesicular body, internal vesicle IDA
IDA: 通过直接分析推断
26280656 GOA
located in plasma membrane IDA
IDA: 通过直接分析推断
22096579 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

LAPTM4B 蛋白结构

Mtp

Mtp: Golgi 4-transmembrane spanning transporter (155 - 317)

  • 0
  • 100
  • 200
  • 317 a.a.
蛋白主名 其他名称

lysosomal-associated transmembrane protein 4B

lysosomal associated protein transmembrane 4 beta

LAPTM4B 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra LAPTM4B Q86VI4 CYB561A3 Homo sapiens Q8NBI2
Validated Y2H
32296183
Intra LAPTM4B Q86VI4 GPX8 Homo sapiens Q8TED1
Validated Y2H
32296183
Intra LAPTM4B Q86VI4 GPX8 Homo sapiens Q8TED1
Y2H Prey Pooling
32296183
Intra LAPTM4B Q86VI4 GPX8 Homo sapiens Q8TED1
Y2H Array
32296183
Intra LAPTM4B Q86VI4 ODF4 Homo sapiens Q2M2E3
Y2H Array
32296183
Intra LAPTM4B Q86VI4 ODF4 Homo sapiens Q2M2E3
Y2H Prey Pooling
32296183
Intra LAPTM4B Q86VI4 ISLR2 Homo sapiens Q6UXK2
Y2H Array
32296183
Intra LAPTM4B Q86VI4 ISLR2 Homo sapiens Q6UXK2
Y2H Prey Pooling
32296183
Intra LAPTM4B Q86VI4 NRG1 Homo sapiens Q02297-10
Y2H Array
32296183
Intra LAPTM4B Q86VI4 NRG1 Homo sapiens Q02297-10
Y2H Prey Pooling
32296183
Intra LAPTM4B Q86VI4 GJA8 Homo sapiens P48165
Y2H Array
32296183
Intra LAPTM4B Q86VI4 GJA8 Homo sapiens P48165
Y2H Prey Pooling
32296183
Intra LAPTM4B Q86VI4 CGRRF1 Homo sapiens Q99675
Validated Y2H
32296183
Intra LAPTM4B Q86VI4 CGRRF1 Homo sapiens Q99675
Y2H Array
32296183
Intra LAPTM4B Q86VI4 CGRRF1 Homo sapiens Q99675
Y2H Prey Pooling
32296183
Intra LAPTM4B Q86VI4 TMEM86B Homo sapiens Q8N661
Validated Y2H
32296183
Intra LAPTM4B Q86VI4 q96fb2_human Homo sapiens Q96FB2
Validated Y2H
32296183
Intra LAPTM4B Q86VI4 EXOC4 Homo sapiens Q96A65
Anti Bait CoIP
25594178
Intra LAPTM4B Q86VI4 EXOC4 Homo sapiens Q96A65
Anti Tag CoIP
25594178
Intra LAPTM4B Q86VI4 MTIF3 Homo sapiens Q9H2K0
Y2H Prey Pooling
32296183
Intra LAPTM4B Q86VI4 MTIF3 Homo sapiens Q9H2K0
Validated Y2H
32296183
Intra LAPTM4B Q86VI4 MTIF3 Homo sapiens Q9H2K0
Y2H Array
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Gallbladder Cancer

Gallbladder Carcinoma

Gallbladder Neoplasm

Malignant Neoplasm Of Gallbladder

Malignant Tumour Of Gallbladder

Gallbladder Ca

Localized Malignant Gallbladder Neoplasm

Malignant Tumor Of The Gallbladder

Tumor Of The Gallbladder

Cancer Of The Gallbladder

Carcinoma Gallbladder

Carcinoma Of Gallbladder

Gallbladder Neoplasms

Malignant Neoplasm Of Gallbladder Localized

Cancer Of Gallbladder

Primary Malignant Neoplasm Of Gallbladder

Hepatocellular Carcinoma

Liver Cancer

Primary Liver Cancer

HCC

Hepatoma

Malignant Neoplasm Of Liver

Liver Neoplasms

Cancer, Hepatocellular

Liver Cell Carcinoma

Lcc

Hepatoblastoma, Somatic

Hepatic Cancer

Primary Malignant Neoplasm Of Liver

Rare Tumor Of Liver And Intrahepatic Biliary Tract

Hepatocellular Carcinoma, Somatic

Hepatocellular Carcinoma, Childhood Type, Somatic

Hepatocellular Cancer, Somatic

Ca Liver - Primary

Hepatic Neoplasm

Malignant Hepato-Biliary Neoplasm

Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary

Malignant Neoplasm Of Liver, Primary

Malignant Tumor Of Liver

Neoplasm Of Liver

Non-Resectable Primary Hepatic Malignant Neoplasm

Resectable Malignant Neoplasm Of Liver

Resectable Malignant Neoplasm Of The Liver

Primary Liver Carcinoma

Primary Malignant Liver Neoplasm

Primary Cancer Of Liver

Primary Tumor Of The Liver

Rare Tumor Of Liver And Ibt

Hepatocellular Cancer

Neoplasm Of The Liver

Carcinoma, Hepatocellular

Hepatomas

Liver Neoplasm

Liver Carcinoma

Liver And Intrahepatic Biliary Tract Carcinoma

Malignant Hepatobiliary Neoplasm

Adult Primary Hepatocellular Carcinoma

Hepatoblastoma

Carcinoma Of Liver

Malignant Liver Tumour

Malignant Hepatic Tumour

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Felis catus LAPTM4B VGNC VGNC:81664
Canis familiaris LAPTM4B VGNC VGNC:54319
Mus musculus LAPTM4B MGD MGI:1890494
Macaca mulatta LAPTM4B VGNC VGNC:84010
Rattus norvegicus LAPTM4B RGD RGD:1311853