LAPTM4B - lysosomal protein transmembrane 4 beta Gene

中文名称：溶酶体蛋白跨膜 4 beta

种属: Homo sapiens

同用名: LC27; LAPTM4beta

基因 ID: 55353 | 基因类型: protein coding

关于 LAPTM4B

Cytogenetic location: 8q22.1 Genomic coordinates (GRCh38): 8:97,775,788-97,853,013 (from NCBI)

This gene has 4 transcripts (splice variants), 288 orthologues and 2 paralogues. Ubiquitous expression in heart (RPKM 97.2), testis (RPKM 52.3) and 23 other tissues.

功能概要

启用神经酰胺结合活性；酶结合活性；和磷脂酰肌醇二磷酸结合活性。参与多个过程，包括大分子代谢过程的负调控；调节溶酶体膜通透性；和溶酶体组织的调节。位于多种细胞成分中，包括核内体；溶酶体膜；和质膜。 [由基因组资源联盟提供，2022 年 4 月]

Enables ceramide binding activity; Enzyme binding activity; and phosphatidylinositol bisphosphate binding activity. Involved in several processes, including negative regulation of macromolecule metabolic process; regulation of lysosomal membrane permeability; and regulation of lysosome organization. Located in several cellular components, including endosome; lysosomal membrane; and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

LAPTM4B 基因产物(1)

mRNA	Protein	Name
NM_018407.6	NP_060877.4	lysosomal-associated transmembrane protein 4B

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables ceramide binding	IDA IDA: 通过直接分析推断	26280656	GOA
enables kinase binding	IPI IPI: 通过物理相互作用推断	25588945	GOA
enables phosphatidylinositol bisphosphate binding	IDA IDA: 通过直接分析推断	25588945	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	20711237	GOA
enables ubiquitin protein ligase binding	IPI IPI: 通过物理相互作用推断	25588945	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in endosome organization	IMP IMP: 通过突变表型推断	21224396	GOA
involved in endosome transport via multivesicular body sorting pathway	IDA IDA: 通过直接分析推断	25588945	GOA
involved in negative regulation of lysosomal protein catabolic process	IMP IMP: 通过突变表型推断	25588945	GOA
involved in negative regulation of transforming growth factor beta1 production	IDA IDA: 通过直接分析推断	26126825	GOA
involved in regulation of lysosomal membrane permeability	IMP IMP: 通过突变表型推断	26280656	GOA
involved in regulation of lysosome organization	IMP IMP: 通过突变表型推断	26280656	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in cell projection	IDA IDA: 通过直接分析推断	22096579	GOA
located in early endosome	IDA IDA: 通过直接分析推断	25588945	GOA
located in endosome	IDA IDA: 通过直接分析推断	25588945	GOA
located in late endosome membrane	IDA IDA: 通过直接分析推断	21224396	GOA
located in lysosomal membrane	IDA IDA: 通过直接分析推断	21224396	GOA
located in lysosome	IDA IDA: 通过直接分析推断	25588945	GOA
located in multivesicular body membrane	IDA IDA: 通过直接分析推断	25588945	GOA
located in multivesicular body, internal vesicle	IDA IDA: 通过直接分析推断	26280656	GOA
located in plasma membrane	IDA IDA: 通过直接分析推断	22096579	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

LAPTM4B 蛋白结构

Mtp

0
100
200
317 a.a.

蛋白主名

其他名称

lysosomal-associated transmembrane protein 4B

lysosomal associated protein transmembrane 4 beta

LAPTM4B 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	LAPTM4B	Q86VI4	CYB561A3	Homo sapiens	Q8NBI2	Validated Y2H	32296183
种属内	LAPTM4B	Q86VI4	GPX8	Homo sapiens	Q8TED1	Validated Y2H	32296183
种属内	LAPTM4B	Q86VI4	GPX8	Homo sapiens	Q8TED1	Y2H Prey Pooling	32296183
种属内	LAPTM4B	Q86VI4	GPX8	Homo sapiens	Q8TED1	Y2H Array	32296183
种属内	LAPTM4B	Q86VI4	ODF4	Homo sapiens	Q2M2E3	Y2H Array	32296183
种属内	LAPTM4B	Q86VI4	ODF4	Homo sapiens	Q2M2E3	Y2H Prey Pooling	32296183
种属内	LAPTM4B	Q86VI4	ISLR2	Homo sapiens	Q6UXK2	Y2H Array	32296183
种属内	LAPTM4B	Q86VI4	ISLR2	Homo sapiens	Q6UXK2	Y2H Prey Pooling	32296183
种属内	LAPTM4B	Q86VI4	NRG1	Homo sapiens	Q02297-10	Y2H Array	32296183
种属内	LAPTM4B	Q86VI4	NRG1	Homo sapiens	Q02297-10	Y2H Prey Pooling	32296183
种属内	LAPTM4B	Q86VI4	GJA8	Homo sapiens	P48165	Y2H Array	32296183
种属内	LAPTM4B	Q86VI4	GJA8	Homo sapiens	P48165	Y2H Prey Pooling	32296183
种属内	LAPTM4B	Q86VI4	CGRRF1	Homo sapiens	Q99675	Validated Y2H	32296183
种属内	LAPTM4B	Q86VI4	CGRRF1	Homo sapiens	Q99675	Y2H Array	32296183
种属内	LAPTM4B	Q86VI4	CGRRF1	Homo sapiens	Q99675	Y2H Prey Pooling	32296183
种属内	LAPTM4B	Q86VI4	TMEM86B	Homo sapiens	Q8N661	Validated Y2H	32296183
种属内	LAPTM4B	Q86VI4	q96fb2_human	Homo sapiens	Q96FB2	Validated Y2H	32296183
种属内	LAPTM4B	Q86VI4	EXOC4	Homo sapiens	Q96A65	Anti Bait CoIP	25594178
种属内	LAPTM4B	Q86VI4	EXOC4	Homo sapiens	Q96A65	Anti Tag CoIP	25594178
种属内	LAPTM4B	Q86VI4	MTIF3	Homo sapiens	Q9H2K0	Y2H Prey Pooling	32296183
种属内	LAPTM4B	Q86VI4	MTIF3	Homo sapiens	Q9H2K0	Validated Y2H	32296183
种属内	LAPTM4B	Q86VI4	MTIF3	Homo sapiens	Q9H2K0	Y2H Array	32296183

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Gallbladder Cancer

Gallbladder Carcinoma	Gallbladder Neoplasm
Malignant Neoplasm Of Gallbladder	Malignant Tumour Of Gallbladder
Gallbladder Ca	Localized Malignant Gallbladder Neoplasm
Malignant Tumor Of The Gallbladder	Tumor Of The Gallbladder
Cancer Of The Gallbladder	Carcinoma Gallbladder
Carcinoma Of Gallbladder	Gallbladder Neoplasms
Malignant Neoplasm Of Gallbladder Localized	Cancer Of Gallbladder
Primary Malignant Neoplasm Of Gallbladder

Hepatocellular Carcinoma

Liver Cancer	Primary Liver Cancer
HCC	Hepatoma
Malignant Neoplasm Of Liver	Liver Neoplasms
Cancer, Hepatocellular	Liver Cell Carcinoma
Lcc	Hepatoblastoma, Somatic
Hepatic Cancer	Primary Malignant Neoplasm Of Liver
Rare Tumor Of Liver And Intrahepatic Biliary Tract	Hepatocellular Carcinoma, Somatic
Hepatocellular Carcinoma, Childhood Type, Somatic	Hepatocellular Cancer, Somatic
Ca Liver - Primary	Hepatic Neoplasm
Malignant Hepato-Biliary Neoplasm	Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary
Malignant Neoplasm Of Liver, Primary	Malignant Tumor Of Liver
Neoplasm Of Liver	Non-Resectable Primary Hepatic Malignant Neoplasm
Resectable Malignant Neoplasm Of Liver	Resectable Malignant Neoplasm Of The Liver
Primary Liver Carcinoma	Primary Malignant Liver Neoplasm
Primary Cancer Of Liver	Primary Tumor Of The Liver
Rare Tumor Of Liver And Ibt	Hepatocellular Cancer
Neoplasm Of The Liver	Carcinoma, Hepatocellular
Hepatomas	Liver Neoplasm
Liver Carcinoma	Liver And Intrahepatic Biliary Tract Carcinoma
Malignant Hepatobiliary Neoplasm	Adult Primary Hepatocellular Carcinoma
Hepatoblastoma	Carcinoma Of Liver
Malignant Liver Tumour	Malignant Hepatic Tumour

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS07522	LAPTM4B Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Felis catus	LAPTM4B	VGNC	VGNC:81664
Canis familiaris	LAPTM4B	VGNC	VGNC:54319
Mus musculus	LAPTM4B	MGD	MGI:1890494
Macaca mulatta	LAPTM4B	VGNC	VGNC:84010
Rattus norvegicus	LAPTM4B	RGD	RGD:1311853

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

LAPTM4B - lysosomal protein transmembrane 4 beta Gene

关于 LAPTM4B

功能概要

LAPTM4B 基因产物(1)

LAPTM4B 蛋白结构

LAPTM4B 蛋白互作信息

关联疾病

直系同源

热门区域

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LAPTM4B - lysosomal protein transmembrane 4 beta Gene

关于 LAPTM4B

功能概要

LAPTM4B 基因产物(1)

LAPTM4B 蛋白结构

LAPTM4B 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z