1. Gene
  2. ISLR2 - immunoglobulin superfamily containing leucine rich repeat 2 Gene

ISLR2 - immunoglobulin superfamily containing leucine rich repeat 2 Gene

中文名称:含免疫球蛋白超家族的富含亮氨酸重复序列 2

种属: Homo sapiens

同用名: LINX

基因 ID: 57611 | 基因类型: protein coding

关于 ISLR2

Cytogenetic location: 15q24.1 Genomic coordinates (GRCh38): 15:74,100,318-74,141,826 (from NCBI)

This gene has 11 transcripts (splice variants), 100 orthologues and 3 paralogues. Biased expression in brain (RPKM 4.7), testis (RPKM 3.0) and 5 other tissues.

功能概要

预计参与轴突延伸的正调控。预测位于质膜中。预计是膜的组成部分。预计在细胞表面有活性。 [由基因组资源联盟提供,2022 年 4 月]

Predicted to be involved in positive regulation of axon extension. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Predicted to be active in cell surface. [provided by Alliance of Genome Resources, Apr 2022]

ISLR2 基因产物(4)

mRNA Protein Name
NM_001130136.1 NP_001123608.1 immunoglobulin superfamily containing leucine-rich repeat protein 2 precursor
NM_001130137.1 NP_001123609.1 immunoglobulin superfamily containing leucine-rich repeat protein 2 precursor
NM_001130138.2 NP_001123610.1 immunoglobulin superfamily containing leucine-rich repeat protein 2 precursor
NM_020851.3 NP_065902.1 immunoglobulin superfamily containing leucine-rich repeat protein 2 precursor
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
32296183 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

ISLR2 蛋白结构

LRR_8

LRR_8: Leucine rich repeat (52 - 109)

LRR_8

LRR_8: Leucine rich repeat (124 - 182)

Ig_2

Ig_2: Immunoglobulin domain (240 - 372)

  • 0
  • 200
  • 400
  • 600
  • 745 a.a.
蛋白主名 其他名称

immunoglobulin superfamily containing leucine-rich repeat protein 2

leucine-rich repeat domain and immunoglobulin domain-containing axon extension protein

ISLR2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
ISLR2 Q6UXK2 LAPTM4B Homo sapiens Q86VI4
Validated Y2H
32296183
种属内
ISLR2 Q6UXK2 MRAP2 Homo sapiens Q96G30
Validated Y2H
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Melanotic Medulloblastoma

Medulloblastoma, Melanotic

Breast Angiosarcoma

Angiosarcoma Of The Breast

Hemangiosarcoma Of The Breast

Primary Angiosarcoma Of Breast

Breast Sarcoma

Sarcoma Of Breast

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Mus musculus ISLR2 MGD MGI:2444277
Rattus norvegicus ISLR2 RGD RGD:6497037
Bos taurus ISLR2 VGNC VGNC:30299
Macaca mulatta ISLR2 VGNC VGNC:73682
Canis familiaris ISLR2 VGNC VGNC:59114
Felis catus ISLR2 VGNC VGNC:80947