STRADB - STE20 related adaptor beta Gene

中文名称：STE20 相关适配器测试版

种属: Homo sapiens

同用名: PAPK; ILPIP; ILPIPA; ALS2CR2; CALS-21; PRO1038

关于 STRADB

功能概要

该基因编码一种属于丝氨酸/苏氨酸蛋白激酶 STE20 亚家族的蛋白质。该蛋白的蛋白激酶结构域中的一个活性位点残基发生了改变，因此它是一种假激酶。这种蛋白质是参与激活丝氨酸/苏氨酸激酶 11 的复合物的成分，后者是一种调节细胞极性和能量产生代谢的主激酶。该复合物调节该激酶从细胞核向细胞质的重新定位，对于该激酶介导的 G1 细胞周期停滞至关重要。该基因编码的蛋白还可以与 X 染色体连锁的凋亡抑制蛋白相互作用，这种相互作用通过 JNK1 信号转导途径增强该蛋白的抗凋亡活性。已发现该基因的两个假基因，位于 1 号和 7 号染色体上。已发现该基因编码不同亚型的可变剪接转录物变体。[RefSeq 提供，2011 年 5 月]

This gene encodes a protein that belongs to the serine/threonine protein kinase STE20 subfamily. One of the active site residues in the protein kinase domain of this protein is altered, and it is thus a pseudokinase. This protein is a component of a complex involved in the activation of serine/threonine kinase 11, a master kinase that regulates cell polarity and energy-generating metabolism. This complex regulates the relocation of this kinase from the nucleus to the cytoplasm, and it is essential for G1 cell cycle arrest mediated by this kinase. The protein encoded by this gene can also interact with the X chromosome-linked inhibitor of Apoptosis protein, and this interaction enhances the anti-apoptotic activity of this protein via the JNK1 signal transduction pathway. Two pseudogenes, located on chromosomes 1 and 7, have been found for this gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2011]