PRH1 - proline rich protein HaeIII subfamily 1 Gene

中文名称：富脯氨酸的蛋白质 HaeIII 亚家族 1

种属: Homo sapiens

同用名: PA; Db-s; PRH2; PIF-S; Pr1/Pr2; PRP-1/PRP-2

关于 PRH1

功能概要

该基因编码富含脯氨酸的唾液糖蛋白的异质家族成员。编码的前原蛋白在从腮腺和下颌下腺/舌下腺分泌之前经过蛋白水解处理以产生一种或多种成熟的亚型。该基因座的多个不同等位基因包括腮腺等电聚焦变体慢 (PIF-s) 、腮腺酸性蛋白 (Pa) 和双带慢 (Db-s) 亚型。参考基因组编码 Db-s 等位基因。该基因的某些等位基因与龋齿易感性有关。该基因位于 12 号染色体上的一组密切相关的富含脯氨酸的唾液蛋白中。已观察到该基因与相邻基因的共转录。该基因的交替剪接导致编码不同亚型的多个转录变体。[RefSeq 提供，2015 年 10 月]

This gene encodes a member of the heterogeneous family of proline-rich salivary glycoproteins. The encoded preproprotein undergoes proteolytic processing to generate one or more mature isoforms before secretion from the parotid and submandibular/sublingual glands. Multiple distinct alleles of this locus including the parotid isoelectric-focusing variant slow (PIF-s), the parotid acidic protein (Pa), and the double band slow (Db-s) isoforms have been characterized. The reference genome encodes the Db-s allele. Certain alleles of this gene are associated with susceptibility to dental caries. This gene is located in a cluster of closely related salivary proline-rich proteins on chromosome 12. Co-transcription of this gene with adjacent genes has been observed. Alternate splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2015]