2. Gene
  3. ERBIN - erbb2 interacting protein Gene

ERBIN - erbb2 interacting protein Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：erbb2 相互作用蛋白

种属: Homo sapiens

同用名: LAP2; ERBB2IP; HEL-S-78

基因 ID: 55914 | 基因类型: protein coding

关于 ERBIN

Cytogenetic location: 5q12.3 Genomic coordinates (GRCh38): 5:65,926,575-66,082,546 (from NCBI)

This gene has 30 transcripts (splice variants), 196 orthologues and 31 paralogues. Ubiquitous expression in small intestine (RPKM 17.6), lymph node (RPKM 17.5) and 25 other tissues.

功能概要

该基因是富含亮氨酸重复序列和 PDZ 结构域 (LAP) 家族的成员。编码的蛋白质包含 17 个富含亮氨酸的重复序列和一个 PDZ 结构域。它与 ERBB2 蛋白的非磷酸化形式结合并调节 ERBB2 功能和定位。它还显示通过破坏 Ras-Raf 相互作用来影响 Ras 信号通路。已经观察到该基因编码多种亚型的可变剪接转录物变体。[RefSeq 提供，2011 年 11 月]

This gene is a member of the leucine-rich repeat and PDZ domain (LAP) family. The encoded protein contains 17 leucine-rich repeats and one PDZ domain. It binds to the unphosphorylated form of the ERBB2 protein and regulates ERBB2 function and localization. It has also been shown to affect the Ras signaling pathway by disrupting Ras-Raf interaction. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]

ERBIN 基因产物(6)

mRNA Protein Name
NM_001006600.3 NP_001006600.1 erbin isoform 7
NM_001253697.2 NP_001240626.1 erbin isoform 1
NM_001253698.2 NP_001240627.1 erbin isoform 4
NM_001253699.2 NP_001240628.1 erbin isoform 8
NM_001253701.2 NP_001240630.1 erbin isoform 9
NM_018695.4 NP_061165.1 erbin isoform 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
11375975 GOA
enables signaling receptor binding IPI
IPI: 通过物理相互作用推断
16203728 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cellular response to tumor necrosis factor IMP
IMP: 通过突变表型推断
16203728 GOA
involved in negative regulation of NF-kappaB transcription factor activity IMP
IMP: 通过突变表型推断
16203728 GOA
involved in negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway IMP
IMP: 通过突变表型推断
16203728 GOA
involved in response to lipopolysaccharide IMP
IMP: 通过突变表型推断
16203728 GOA
involved in response to muramyl dipeptide IMP
IMP: 通过突变表型推断
16203728 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in basolateral plasma membrane IDA
IDA: 通过直接分析推断
16203728 GOA
located in cytoplasm IDA
IDA: 通过直接分析推断
11375975 GOA
located in hemidesmosome IDA
IDA: 通过直接分析推断
11375975 GOA
located in nucleus IDA
IDA: 通过直接分析推断
11375975 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

ERBIN 蛋白结构

LRR_4

LRR_4: Leucine Rich repeats (2 copies) (70 - 108)

LRR_4

LRR_4: Leucine Rich repeats (2 copies) (161 - 201)

LRR_8

LRR_8: Leucine rich repeat (208 - 265)

LRR_8

LRR_8: Leucine rich repeat (346 - 402)

PDZ

PDZ: PDZ domain (Also known as DHR or GLGF) (1328 - 1406)

  • 0
  • 300
  • 600
  • 900
  • 1200
  • 1412 a.a.
蛋白主名 其他名称

erbin

densin-180-like protein

ERBIN 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
ERBIN Q96RT1 PKP4 Homo sapiens Q99569
IF
12047349
种属内
ERBIN Q96RT1 PKP4 Homo sapiens Q99569
Phage Display
24550280
种属内
ERBIN Q96RT1 PKP4 Homo sapiens Q99569
Anti Bait CoIP
12047349
种属内
ERBIN Q96RT1 NOD2 Homo sapiens Q9HC29
Anti Bait CoIP
16203728
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Petrous Apex Meningioma

Meningioma Of The Petrous Ridge
Cri-Du-Chat Syndrome

5p Deletion Syndrome

5p Partial Monosomy Syndrome

Monosomy 5p

Cat Cry Syndrome

Chromosome 5p Deletion Syndrome

Cri Du Chat Syndrome

5p- Syndrome

5p Minus Syndrome

Chromosome 5p- Syndrome

Chromosome 5 Short Arm Deletion Syndrome

Chromosome 5p Deletion

Deletion 5p

Cri Du Chat

5p Partial Deletion Syndrome

Partial Deletion Of Short Arm Of Chromosome 5 Syndrome
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS04475 ERBIN Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus ERBIN RGD RGD:1562952
Canis familiaris ERBIN VGNC VGNC:40438
Bos taurus ERBIN VGNC VGNC:28565
Mus musculus ERBIN MGD MGI:1890169
Felis catus ERBIN VGNC VGNC:102196
Macaca mulatta ERBIN VGNC VGNC:81395
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