1. Gene
  2. Paxip1 - PAX interacting (with transcription-activation domain) protein 1 Gene

Paxip1 - PAX interacting (with transcription-activation domain) protein 1 Gene

种属: Mus musculus

同用名: PTIP; D5Ertd149e

基因 ID: 55982 | 基因类型: protein coding

关于 Paxip1

功能概要

This gene encodes a nuclear-localized protein that contains six BRCT1 (C-terminal of breast Cancer susceptibility protein) domains. The encoded protein is involved in the repair of DNA double-strand breaks and is necessary for progression through cell division. The protein also functions in the regulation of transcription by recruiting histone methyltransferases to gene promoters bound by the sequence-specific transcription factor paired box protein 2 (Pax2). [provided by RefSeq, Mar 2013]

Paxip1 基因产物(1)

mRNA Protein Name
NM_018878.4 NP_061366.2 PAX-interacting protein 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
10908331 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within DNA damage response IDA
IDA: 通过直接分析推断
17500065 MGI
involved in DNA damage response IMP
IMP: 通过突变表型推断
19124460 MGI
involved in adipose tissue development IMP
IMP: 通过突变表型推断
19583951 MGI
involved in chorion development IMP
IMP: 通过突变表型推断
18710940 MGI
involved in endothelial cell migration IMP
IMP: 通过突变表型推断
18710940 MGI
involved in positive regulation of isotype switching IMP
IMP: 通过突变表型推断
20671152 MGI
involved in positive regulation of isotype switching to IgG isotypes IMP
IMP: 通过突变表型推断
26744420 MGI
involved in positive regulation of protein ubiquitination IMP
IMP: 通过突变表型推断
18353733 MGI
involved in positive regulation of transcription initiation by RNA polymerase II IMP
IMP: 通过突变表型推断
19583951 MGI
involved in regulation of cell cycle G2/M phase transition IMP
IMP: 通过突变表型推断
19124460 MGI
involved in vasculogenesis IMP
IMP: 通过突变表型推断
18710940 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of histone methyltransferase complex IDA
IDA: 通过直接分析推断
17500065 MGI
located in nucleus IDA
IDA: 通过直接分析推断
10908331 MGI
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断
蛋白主名 其他名称

PAX-interacting protein 1

PAX transactivation activation domain-interacting protein

Paxip1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
Paxip1 Q6NZQ4 Pagr1a Mus musculus Q99L02
TSA
26744420
种属内
Paxip1 Q6NZQ4 Pagr1a Mus musculus Q99L02
Anti Tag CoIP
26744420
种属内
Paxip1 Q6NZQ4 Pagr1a Mus musculus Q99L02
ITC
26744420
种属内
Paxip1 Q6NZQ4 Pagr1a Mus musculus Q99L02
Pull Down
26744420
种属内
Paxip1 Q6NZQ4 Pax2 Mus musculus P32114
Anti Tag CoIP
10908331
种属内
Paxip1 Q6NZQ4 Pax2 Mus musculus P32114
IF
10908331
种属内
Paxip1 Q6NZQ4 Pax2 Mus musculus P32114-2
Pull Down
10908331
种属间
Paxip1 Q6NZQ4 PAGR1 Homo sapiens Q9BTK6
Anti Tag CoIP
17500065
种属间
Paxip1 Q6NZQ4 PAGR1 Homo sapiens Q9BTK6
Pull Down
19124460
种属内
Paxip1 Q6NZQ4 Pax5 Mus musculus Q02650
Anti Bait CoIP
21552207
种属内
Paxip1 Q6NZQ4 Pax5 Mus musculus Q02650
Anti Tag CoIP
21552207
种属间
Paxip1 Q6NZQ4 TP53BP1 Homo sapiens Q12888
Pull Down
19124460
种属间
Paxip1 Q6NZQ4 TP53BP1 Homo sapiens Q12888
Anti Tag CoIP
17500065
种属间
Paxip1 Q6NZQ4 TP53BP1 Homo sapiens Q12888
Anti Tag CoIP
17925232
种属间: 跨种属相互作用 种属内: 同种属相互作用

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Paxip1 NCBI NCBI:22976