Pax2 - paired box 2 Gene

种属: Mus musculus

同用名: Opdc; Pax-2

关于 Pax2

功能概要

Enables C2H2 zinc finger domain binding activity; DNA-binding transcription factor activity, RNA polymerase II-specific; and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including negative regulation of apoptotic process involved in development; nervous system development; and urogenital system development. Acts upstream of or within several processes, including animal organ development; cellular response to mechanical stimulus; and regulation of transcription by RNA polymerase II. Located in nucleus. Part of protein-DNA complex. Is expressed in several structures, including central nervous system; embryo ectoderm; genitourinary system; sensory organ; and tibia. Used to study renal coloboma syndrome. Human ortholog(s) of this gene implicated in focal segmental glomerulosclerosis 7 and renal coloboma syndrome. Orthologous to human PAX2 (paired box 2). [provided by Alliance of Genome Resources, Apr 2022]