PROC - protein C, inactivator of coagulation factors Va and VIIIa Gene

中文名称：蛋白 C，凝血因子 Va 和 VIIIa 的灭活因子

种属: Homo sapiens

同用名: PC; APC; PROC1; THPH3; THPH4

基因 ID: 5624 | 基因类型: protein coding

关于 PROC

Cytogenetic location: 2q14.3 Genomic coordinates (GRCh38): 2:127,418,427-127,429,242 (from NCBI)

This gene has 10 transcripts (splice variants), 102 orthologues, 1 paralogue and is associated with 4 phenotypes. Biased expression in liver (RPKM 55.9) and kidney (RPKM 6.8).

功能概要

该基因编码维生素 K 依赖性血浆糖蛋白。编码的蛋白质被凝血酶-凝血调节蛋白复合物切割成其活化形式。这种活化形式包含丝氨酸蛋白酶结构域，并在凝血因子 V 和 VIII 的活化形式的降解中发挥作用。该基因的突变与蛋白 C 缺乏引起的血栓形成倾向、新生儿暴发性紫癜和复发性静脉血栓形成有关。[RefSeq 提供，2009 年 12 月]

This gene encodes a vitamin K-dependent plasma glycoprotein. The encoded protein is cleaved to its activated form by the thrombin-thrombomodulin complex. This activated form contains a serine protease domain and functions in degradation of the activated forms of coagulation factors V and VIII. Mutations in this gene have been associated with thrombophilia due to protein C deficiency, neonatal purpura fulminans, and recurrent venous thrombosis.[provided by RefSeq, Dec 2009]

PROC 基因产物(12)

mRNA	Protein	Name
NM_000312.4	NP_000303.1	vitamin K-dependent protein C isoform 10 preproprotein
NM_001375602.1	NP_001362531.1	vitamin K-dependent protein C isoform 2
NM_001375603.1	NP_001362532.1	vitamin K-dependent protein C isoform 4 precursor
NM_001375604.1	NP_001362533.1	vitamin K-dependent protein C isoform 6 precursor
NM_001375605.1	NP_001362534.1	vitamin K-dependent protein C isoform 5 preproprotein
NM_001375606.1	NP_001362535.1	vitamin K-dependent protein C isoform 3 precursor
NM_001375607.1	NP_001362536.1	vitamin K-dependent protein C isoform 1
NM_001375608.1	NP_001362537.1	vitamin K-dependent protein C isoform 9 precursor
NM_001375609.1	NP_001362538.1	vitamin K-dependent protein C isoform 8
NM_001375610.1	NP_001362539.1	vitamin K-dependent protein C isoform 7 preproprotein
NM_001375611.1	NP_001362540.1	vitamin K-dependent protein C isoform 10 preproprotein
NM_001375613.1	NP_001362542.1	vitamin K-dependent protein C isoform 10 preproprotein

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	15248212	GOA
enables serine-type endopeptidase activity	IMP IMP: 通过突变表型推断	25748729	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in negative regulation of apoptotic process	IMP IMP: 通过突变表型推断	12563316	GOA
involved in negative regulation of coagulation	IMP IMP: 通过突变表型推断	25651845	GOA
involved in negative regulation of inflammatory response	IMP IMP: 通过突变表型推断	25651845	GOA
involved in positive regulation of establishment of endothelial barrier	IMP IMP: 通过突变表型推断	25651845	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in Golgi apparatus	IDA IDA: 通过直接分析推断	25748729	GOA
located in endoplasmic reticulum	IDA IDA: 通过直接分析推断	25748729	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

PROC 蛋白结构

Gla

FXa_inhibition

Trypsin

0
100
200
300
400
461 a.a.

蛋白主名

其他名称

vitamin K-dependent protein C

Protein C-Nagoya

PROC 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	PROC	P04070	MMP15	Homo sapiens	P51511	Anti Bait CoIP	15248212
种属内	PROC	P04070	CYSRT1	Homo sapiens	A8MQ03	Y2H Array	32296183
种属内	PROC	P04070	CYSRT1	Homo sapiens	A8MQ03	Y2H Prey Pooling	32296183

种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 PROC 蛋白

目录号	产品名	蛋白编号	纯度
HY-P74237	Coagulation Factor XIV/PROC Protein, Human (HEK293, His)	P04070 (T19-P461)	≥95%

PROC 抗体

目录号	产品名	应用	反应物种
HY-P82716	Protein C Antibody (YA2461)	WB	Human

关联疾病

疾病名称

别名

Thrombophilia Due To Protein C Deficiency, Autosomal Recessive

THPH4	Autosomal Recessive Thrombophilia Due To Protein C Deficiency
Autosomal Recessive Protein C Deficiency	Autosomal Recessive Thrombophilia Due To Pc Deficiency
Autosomal Recessive Thrombophilia Due To Congenital Protein C Deficiency	Hereditary Thrombophilia Due To Congenital Protein C Deficiency
Severe Hereditary Thrombophilia Due To Congenital Protein C Deficiency	Protein C Deficiency, Autosomal Recessive
Proc Deficiency, Autosomal Recessive	Thrombophilia 3 Due To Protein C Deficiency, Autosomal Recessive
Autosomal Recessive Proc Deficiency	Autosomal Recessive Hereditary Thrombophilia Due To Protein C Deficiency
Hereditary Thrombophilia Due To Pc Deficiency	Proc Deficiency Autosomal Recessive
Protein C Deficiency Autosomal Recessive	Thrombophilia, Hereditary, Due To Protein C Deficiency, Autosomal Recessive

Thrombophilia Due To Protein C Deficiency, Autosomal Dominant

THPH3	Thrombophilia, Hereditary, Due To Protein C Deficiency, Autosomal Dominant
Protein C Deficiency, Autosomal Dominant	Proc Deficiency, Autosomal Dominant
Thrombophilia 3 Due To Protein C Deficiency, Autosomal Dominant	Autosomal Dominant Thrombophilia Due To Protein C Deficiency
Autosomal Dominant Proc Deficiency	Autosomal Dominant Protein C Deficiency
Proc Deficiency Autosomal Dominant	Protein C Deficiency Autosomal Dominant

Protein C Deficiency

Hereditary Thrombophilia Due To Protein C Deficiency	Proc Deficiency
Congenital Thrombotic Disease, Due To Protein C Deficiency

Purpura Fulminans

Purpura Gangrenosa

Purpura

Purpuric Disorder

Thrombophilia

Hypercoagulability State

Thrombosis

Thrombosis Of Blood Vessel

Thrombophilia Due To Thrombin Defect

Venous Thromboembolism	Venous Thrombosis
Thrombophilia Due To Factor 2 Defect	Thromboembolism
THPH1	Thromboembolism, Susceptibility To
Venous Thromboembolism, Susceptibility To	Venous Thrombosis, Protection Against
Prothrombin-Related Thrombophilia	Hyperprothrombinemia
Venous Thrombosis, Susceptibility To	Thrombophilia 1 Due To Thrombin Defect
F2-Related Thrombophilia	Factor Ii-Related Thrombophilia
Prothrombin 20210g>A Thrombophilia	Prothrombin G20210a Thrombophilia
Prothrombin Thrombophilia

Cerebral Palsy

Infantile Cerebral Palsy	Mixed Cerebral Palsy
Palsy Cerebral	Palsy, Cerebral
Cerebral Palsy, Mixed

Inner Ear Cancer

Internal Auditory Canal Meningioma

Meningioma Of The Internal Auditory Canal

Protein S Deficiency

Protein S Deficiency Disease

Hereditary Thrombophilia Due To Protein S Deficiency

Thrombophlebitis

Phlebitis And Thrombophlebitis Of Superficial Vessels Of Lower Extremities	Superficial Thrombophlebitis Of Leg
Thrombophlebitis Of A Superficial Leg Vein	Thrombophlebitis Of Superficial Veins Of Lower Extremity

Pulmonary Embolism

Pulmonary Artery Embolism	Pulmonary Embolus
Pulmonary Emboli

Neuronal Ceroid Lipofuscinosis

Hereditary Ceroid Lipofuscinosis	Batten Disease
Ncl	Neuronal Ceroid-Lipofuscinoses
Lipofuscinosis, Ceroid, Neuronal	Juvenile Neuronal Ceroid Lipofuscinosis
Cerebromacular Dystrophy	Cerebromacular Degeneration
Ceroid-Lipofuscinosis	Ncl - [Neuronal Ceroid Lipofuscinosis]
Amaurotic Familial Idiocy	Amaurotic Idiocy
Amaurotic Idiot	Neuronal Lipofuscinosis
Pigmentary Retinal Lipoid Neuronal Heredodegeneration

Thrombocytopenia

Low Platelet Count	Low Platelets
Decreased Platelets	Platelet Dysfunction Nos

Inflammatory Bowel Disease

Inflammatory Bowel Diseases

Bowel Disease, Inflammatory

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

目录号	产品名	作用方式	纯度	Phase
HY-P99229	Upifitamab		98.77%	Phase 2

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS11190	PROC Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-E70438	Endoproteinase Pro-C		/	否

直系同源

种属	基因名	来源	基因 ID
Bos taurus	PROC	VGNC	VGNC:56139
Mus musculus	PROC	MGD	MGI:97771
Canis familiaris	PROC	VGNC	VGNC:45006
Rattus norvegicus	PROC	RGD	RGD:3411
Macaca fascicularis	PROC	NCBI	NCBI:102136210
Others	PROC	NCBI

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。	站点地图隐私声明
沪ICP备15051369号-4 上海工商沪公网安备31011502019417 沪(浦)应急管危经许[2021]201709(QFYS) 营业执照（三证合一）
Copyright © 2013-2025 MedChemExpress. All Rights Reserved.

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

PROC - protein C, inactivator of coagulation factors Va and VIIIa Gene

关于 PROC

功能概要

PROC 基因产物(12)

PROC 蛋白结构

PROC 蛋白互作信息

重组 PROC 蛋白

PROC 抗体

关联疾病

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

姓名
邮箱 *

Sorry, but the email address you supplied was invalid.

PROC - protein C, inactivator of coagulation factors Va and VIIIa Gene

关于 PROC

功能概要

PROC 基因产物(12)

PROC 蛋白结构

PROC 蛋白互作信息

重组 PROC 蛋白

PROC 抗体

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z