CTNNBIP1 - catenin beta interacting protein 1 Gene

中文名称：连环蛋白β相互作用蛋白 1

种属: Homo sapiens

同用名: ICAT

基因 ID: 56998 | 基因类型: protein coding

关于 CTNNBIP1

Cytogenetic location: 1p36.22 Genomic coordinates (GRCh38): 1:9,848,276-9,910,269 (from NCBI)

This gene has 4 transcripts (splice variants), 181 orthologues and 1 paralogue. Ubiquitous expression in skin (RPKM 77.0), esophagus (RPKM 25.4) and 24 other tissues.

功能概要

由该基因编码的蛋白质结合 CTNNB1 并阻止 CTNNB1 和 TCF 家族成员之间的相互作用。编码的蛋白质是 Wnt 信号通路的负调节因子。已发现该基因编码相同蛋白质的两个转录变体。[RefSeq 提供，2008 年 7 月]

The protein encoded by this gene binds CTNNB1 and prevents interaction between CTNNB1 and TCF family members. The encoded protein is a negative regulator of the Wnt signaling pathway. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

CTNNBIP1 基因产物(2)

mRNA	Protein	Name
NM_001012329.2	NP_001012329.1	beta-catenin-interacting protein 1
NM_020248.3	NP_064633.1	beta-catenin-interacting protein 1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables armadillo repeat domain binding	IPI IPI: 通过物理相互作用推断	12408825	GOA
enables beta-catenin binding	IPI IPI: 通过物理相互作用推断	12408825	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	12408824	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in negative regulation of DNA-binding transcription factor activity	IMP IMP: 通过突变表型推断	18977368	GOA
involved in negative regulation of mesenchymal cell proliferation	IMP IMP: 通过突变表型推断	18977368	GOA
involved in negative regulation of protein binding	IDA IDA: 通过直接分析推断	12408825	GOA
involved in positive regulation of monocyte differentiation	IMP IMP: 通过突变表型推断	19569129	GOA
involved in positive regulation of osteoblast differentiation	IMP IMP: 通过突变表型推断	18977368	GOA
involved in regulation of vascular permeability involved in acute inflammatory response	IMP IMP: 通过突变表型推断	18287330	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of beta-catenin destruction complex	IDA IDA: 通过直接分析推断	16188939	GOA
located in cytoplasm	IDA IDA: 通过直接分析推断	19569129	GOA
located in cytosol	IDA IDA: 通过直接分析推断	18287330	GOA
located in nucleus	IDA IDA: 通过直接分析推断	18287330	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

CTNNBIP1 蛋白结构

ICAT

0
81 a.a.

蛋白主名

其他名称

beta-catenin-interacting protein 1

beta-catenin-interacting protein ICAT

CTNNBIP1 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	CTNNBIP1	Q9NSA3	KRTAP10-7	Homo sapiens	P60409	Y2H Array	25416956
种属内	CTNNBIP1	Q9NSA3	MSS51	Homo sapiens	Q4VC12	Y2H Array	32296183
种属内	CTNNBIP1	Q9NSA3	MSS51	Homo sapiens	Q4VC12	Y2H Prey Pooling	32296183
种属内	CTNNBIP1	Q9NSA3	KRTAP1-3	Homo sapiens	Q8IUG1	Y2H Prey Pooling	32296183
种属内	CTNNBIP1	Q9NSA3	KRTAP1-3	Homo sapiens	Q8IUG1	Y2H Array	32296183
种属内	CTNNBIP1	Q9NSA3	SPATA24	Homo sapiens	Q86W54-2	Y2H Prey Pooling	32296183
种属内	CTNNBIP1	Q9NSA3	NOTCH2NLC	Homo sapiens	P0DPK4	Y2H Array	32296183
种属内	CTNNBIP1	Q9NSA3	NOTCH2NLC	Homo sapiens	P0DPK4	Y2H Prey Pooling	32296183
种属内	CTNNBIP1	Q9NSA3	REL	Homo sapiens	Q04864	Validated Y2H	25416956
种属内	CTNNBIP1	Q9NSA3	REL	Homo sapiens	Q04864	Y2H Array	25416956
种属内	CTNNBIP1	Q9NSA3	KRTAP5-9	Homo sapiens	P26371	Y2H Prey Pooling	32296183
种属内	CTNNBIP1	Q9NSA3	KRTAP5-9	Homo sapiens	P26371	Y2H Array	32296183
种属间	CTNNBIP1	Q9NSA3	Ctnnb1	Mus musculus	Q02248	ITC	16293619
种属内	CTNNBIP1	Q9NSA3	CTNNB1	Homo sapiens	P35222	Anti Tag CoIP	28514442
种属内	CTNNBIP1	Q9NSA3	CTNNB1	Homo sapiens	P35222	X-Ray Diffraction	12408824
种属内	CTNNBIP1	Q9NSA3	CTNNB1	Homo sapiens	P35222	Competition Binding	18287330
种属内	CTNNBIP1	Q9NSA3	CTNNB1	Homo sapiens	P35222	Anti Tag CoIP	33961781
种属内	CTNNBIP1	Q9NSA3	CTNNB1	Homo sapiens	P35222	Anti Tag CoIP	21885566
种属内	CTNNBIP1	Q9NSA3	CTNNB1	Homo sapiens	P35222	Anti Bait CoIP	17353931
种属内	CTNNBIP1	Q9NSA3	CTNNB1	Homo sapiens	P35222	Pull Down	21885566
种属内	CTNNBIP1	Q9NSA3	CTNNB1	Homo sapiens	P35222	Anti Bait CoIP	21885566
种属内	CTNNBIP1	Q9NSA3	CTNNB1	Homo sapiens	P35222	Pull Down	18287330
种属内	CTNNBIP1	Q9NSA3	INCA1	Homo sapiens	Q0VD86	Validated Y2H	25416956
种属内	CTNNBIP1	Q9NSA3	JUP	Homo sapiens	P14923	Y2H Prey Pooling	32296183
种属内	CTNNBIP1	Q9NSA3	JUP	Homo sapiens	P14923	Anti Tag CoIP	33961781
种属内	CTNNBIP1	Q9NSA3	JUP	Homo sapiens	P14923	Y2H Array	32296183
种属内	CTNNBIP1	Q9NSA3	JUP	Homo sapiens	P14923	Anti Bait CoIP	17353931
种属内	CTNNBIP1	Q9NSA3	USHBP1	Homo sapiens	Q8N6Y0	Y2H Array	25416956

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Cheilitis

Anterior Segment Dysgenesis 5

Anterior Segment Dysgenesis 5, Multiple Subtypes	ASGD5
Dysgenesis, Anterior Segment, Type 5, Multiple Subtypes

Hepatocellular Carcinoma

Liver Cancer	Primary Liver Cancer
HCC	Hepatoma
Malignant Neoplasm Of Liver	Liver Neoplasms
Cancer, Hepatocellular	Liver Cell Carcinoma
Lcc	Hepatoblastoma, Somatic
Hepatic Cancer	Primary Malignant Neoplasm Of Liver
Rare Tumor Of Liver And Intrahepatic Biliary Tract	Hepatocellular Carcinoma, Somatic
Hepatocellular Carcinoma, Childhood Type, Somatic	Hepatocellular Cancer, Somatic
Ca Liver - Primary	Hepatic Neoplasm
Malignant Hepato-Biliary Neoplasm	Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary
Malignant Neoplasm Of Liver, Primary	Malignant Tumor Of Liver
Neoplasm Of Liver	Non-Resectable Primary Hepatic Malignant Neoplasm
Resectable Malignant Neoplasm Of Liver	Resectable Malignant Neoplasm Of The Liver
Primary Liver Carcinoma	Primary Malignant Liver Neoplasm
Primary Cancer Of Liver	Primary Tumor Of The Liver
Rare Tumor Of Liver And Ibt	Hepatocellular Cancer
Neoplasm Of The Liver	Carcinoma, Hepatocellular
Hepatomas	Liver Neoplasm
Liver Carcinoma	Liver And Intrahepatic Biliary Tract Carcinoma
Malignant Hepatobiliary Neoplasm	Adult Primary Hepatocellular Carcinoma
Hepatoblastoma	Carcinoma Of Liver
Malignant Liver Tumour	Malignant Hepatic Tumour

Colorectal Cancer

Colon Cancer	Colorectal Carcinoma
Colon Carcinoma	Colorectal Cancer, Susceptibility To
Carcinoma Of Colon	CRC
Colorectal Cancer With Chromosomal Instability, Somatic	Colon Cancer, Somatic
Colon Cancer, Susceptibility To	Colonic Neoplasms
Colorectal Neoplasms	Colorectal Cancer, Somatic
Colon Cancer, Advanced, Somatic	Colonic Carcinoma
Colorectal Carcinomas	Colon Cancers
Colorectal Cancers	Cancer, Colorectal, Somatic
Cancer, Colon	Cancer, Colorectal, Susceptibility To
Colorectal Neoplasm	Colonic Neoplasm
Malignant Tumor Of Colon

Osteogenesis Imperfecta, Type I

Osteogenesis Imperfecta Type I	OI1
Oi, Type I	Osteogenesis Imperfecta Tarda
Osteogenesis Imperfecta With Blue Sclerae	Osteogenesis Imperfecta Type 1
Adair-Dighton Syndrome	Mild Osteogenesis Imperfecta
Non-Deforming Osteogenesis Imperfecta	Oi Type 1
Van Der Hoeve Syndrome	Classic Non-Deforming Oi With Blue Sclerae
Osteogenesis Imperfecta 1	Oi-I
Osteopenic Non-Fracture Syndrome	Osteogenesis Imperfecta, Mild
Osteogenesis Imperfecta	Lobstein'S Disease

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS03309	CTNNBIP1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Felis catus	CTNNBIP1	VGNC	VGNC:80177
Rattus norvegicus	CTNNBIP1	RGD	RGD:1562749
Bos taurus	CTNNBIP1	VGNC	VGNC:27803
Mus musculus	CTNNBIP1	MGD	MGI:1915756

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。	站点地图隐私声明
沪ICP备15051369号-4 上海工商沪公网安备31011502019417 沪(浦)应急管危经许[2021]201709(QFYS) 营业执照（三证合一）
Copyright © 2013-2025 MedChemExpress. All Rights Reserved.

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

CTNNBIP1 - catenin beta interacting protein 1 Gene

关于 CTNNBIP1

功能概要

CTNNBIP1 基因产物(2)

CTNNBIP1 蛋白结构

CTNNBIP1 蛋白互作信息

关联疾病

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

姓名
邮箱 *

Sorry, but the email address you supplied was invalid.

CTNNBIP1 - catenin beta interacting protein 1 Gene

关于 CTNNBIP1

功能概要

CTNNBIP1 基因产物(2)

CTNNBIP1 蛋白结构

CTNNBIP1 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z