2. Gene
  3. LYRM4 - LYR motif containing 4 Gene

LYRM4 - LYR motif containing 4 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：含 LYR 基序 4

种属: Homo sapiens

同用名: ISD11; CGI-203; COXPD19; C6orf149

基因 ID: 57128 | 基因类型: protein coding

关于 LYRM4

Cytogenetic location: 6p25.1 Genomic coordinates (GRCh38): 6:5,031,753-5,260,950 (from NCBI)

This gene has 9 transcripts (splice variants), 143 orthologues, 1 paralogue and is associated with 2 phenotypes. Ubiquitous expression in ovary (RPKM 2.3), thyroid (RPKM 2.1) and 25 other tissues.

功能概要

由该基因编码的蛋白质存在于线粒体和细胞核中，在那里它结合半胱氨酸脱硫酶并帮助游离无机硫形成 Fe/S 簇。该基因的破坏会对线粒体和胞质铁稳态产生负面影响。[RefSeq 提供，2016 年 9 月]

The protein encoded by this gene is found in both mitochondria and the nucleus, where it binds cysteine desulfurase and helps free inorganic sulfur for Fe/S clusters. Disruption of this gene negatively impacts mitochondrial and cytosolic iron homeostasis. [provided by RefSeq, Sep 2016]

LYRM4 基因产物(5)

mRNA Protein Name
NM_001164840.3 NP_001158312.1 LYR motif-containing protein 4 isoform 2
NM_001164841.3 NP_001158313.1 LYR motif-containing protein 4 isoform 3
NM_001318782.1 NP_001305711.1 LYR motif-containing protein 4 isoform 4
NM_001318783.1 NP_001305712.1 LYR motif-containing protein 4 isoform 5
NM_020408.6 NP_065141.3 LYR motif-containing protein 4 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
18650437 GOA
enables protein homodimerization activity IDA
IDA: 通过直接分析推断
29097656 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in [2Fe-2S] cluster assembly IDA
IDA: 通过直接分析推断
17331979 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of mitochondrial [2Fe-2S] assembly complex IDA
IDA: 通过直接分析推断
21298097 GOA
located in mitochondrion IDA
IDA: 通过直接分析推断
17331979 GOA
located in nucleus IDA
IDA: 通过直接分析推断
23593335 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

LYRM4 蛋白结构

Complex1_LYR_1

Complex1_LYR_1: Complex1_LYR-like (8 - 66)

  • 0
  • 91 a.a.
蛋白主名 其他名称

LYR motif-containing protein 4

homolog of yeast Isd11

LYRM4 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
LYRM4 Q9HD34 NFS1 Homo sapiens Q9Y697
Pull Down
26342079
种属内
LYRM4 Q9HD34 NFS1 Homo sapiens Q9Y697
Anti Tag CoIP
27499296
种属内
LYRM4 Q9HD34 NFS1 Homo sapiens Q9Y697
Anti Tag CoIP
33961781
种属内
LYRM4 Q9HD34 NFS1 Homo sapiens Q9Y697
Light Scattering
26342079
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Combined Oxidative Phosphorylation Deficiency 19

COXPD19

Severe Neonatal Lactic Acidosis Due To Nfs1-Isd11 Complex Deficiency

Combined Oxidative Phosphorylation Deficiency, Type 19
Chromosome 6pter-P24 Deletion Syndrome

6p Subtelomeric Deletion Syndrome

6p25 Microdeletion Syndrome

Distal Monosomy 6p

Distal Deletion 6p

Monosomy 6p25
Friedreich Ataxia

Friedreich Ataxia 1

FRDA

Friedreich Ataxia With Retained Reflexes

Frda1

Fa

Friedreich'S Ataxia

Hereditary Spinal Ataxia

Fa1

Friedreich'S Tabes

Hereditary Spinal Sclerosis

Spinocerebellar Ataxia, Friedreich

Friedreich Spinocerebellar Ataxia

Friedrich'S Ataxia
Combined Oxidative Phosphorylation Deficiency
Multiple Mitochondrial Dysfunctions Syndrome 3

MMDS3

Iba57 Deficiency

Multiple Mitochondrial Dysfunctions Syndrome Type 3

Mitochondrial Dysfunctions, Multiple, Syndrome, Type 3
Lactic Acidosis

Acidosis, Lactic

Acidosis Lactic
Autosomal Recessive Cerebellar Ataxia

Arca
Hereditary Ataxia

Sca

Spinocerebellar Ataxia

Ataxias Hereditary

Ataxias, Hereditary
Cerebellar Disease

Cerebellar Diseases

Cerebellar Dysfunction

Cerebellar Abnormality

Cerebellar Disorders
Gastroesophageal Reflux

Gastroesophageal Reflux Disease

Gerd

GER

Gastroesophageal Reflux, Pediatric

Acid Reflux

Gastresophageal Reflux

Gastro-Esophageal Reflux

Gerd - Gastro-Esophageal Reflux Disease
3-Methylglutaconic Aciduria, Type Iii

Optic Atrophy

3-Methylglutaconic Aciduria Type 3

Costeff Syndrome

Mga3

Costeff Optic Atrophy Syndrome

Optic Atrophy Plus Syndrome

Infantile Optic Atrophy With Chorea And Spastic Paraplegia

3-Methylglutaconic Aciduria Type Iii

Autosomal Recessive Optic Atrophy Plus Syndrome

Autosomal Recessive Optic Atrophy Type 3

Opa3 Defect

MGCA3

Mga, Type Iii

Iraqi Jewish Optic Atrophy Plus

Mga Type Iii

Optic Atrophy, Infantile, With Chorea And Spastic Paraplegia

Iraqi-Jewish 'Optic Atrophy Plus'

Optic Atrophy 3, Autosomal Recessive

Opa3, Autosomal Recessive

Opa3-Related 3-Methylglutaconic Aciduria

Iraqi-Jewish Optic Atrophy Plus

Atrophy Of Optic Disc

3-Alpha Methylglutaconic Aciduria Type Iii

Optic Atrophy 3

Optic Atrophy Infantile With Chorea And Spastic Paraplegia

Autosomal Recessive Opa3

Autosomal Recessive Optic Atrophy 3

3-Methylglutaconic Aciduria 3

3-Alpha-Methylglutaconic Aciduria Type 3

Optic Atrophy 3 Autosomal Recessive

Atrophy, Optic

Atrophy, Optic, Plus Syndrome

Optic Nerve Atrophy

Primary Optic Atrophy

Oa - [Optic Atrophy]

Second Cranial Nerve Atrophy

Second Cranium Nerve Atrophy
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS07924 LYRM4 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus LYRM4 VGNC VGNC:31110
Rattus norvegicus LYRM4 RGD RGD:7672286
Mus musculus LYRM4 MGD MGI:2683538
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