2. Gene
  3. MRTFB - myocardin related transcription factor B Gene

MRTFB - myocardin related transcription factor B Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：心肌素相关转录因子 B

种属: Homo sapiens

同用名: MKL2; MRTF-B; NPD001

基因 ID: 57496 | 基因类型: protein coding

关于 MRTFB

Cytogenetic location: 16p13.12 Genomic coordinates (GRCh38): 16:13,994,774-14,266,779 (from NCBI)

This gene has 13 transcripts (splice variants), 278 orthologues and 2 paralogues. Ubiquitous expression in brain (RPKM 11.0), testis (RPKM 5.1) and 24 other tissues.

功能概要

启用转录共激活因子活性。参与 RNA 聚合酶 II 对 pri-miRNA 转录的正调控和横纹肌组织发育的正调控。预计位于细胞质中。预计活跃于核心。 [由基因组资源联盟提供，2022 年 4 月]

Enables transcription coactivator activity. Involved in positive regulation of pri-miRNA transcription by RNA polymerase II and positive regulation of striated muscle tissue development. Predicted to be located in cytoplasm. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]

MRTFB 基因产物(13)

mRNA Protein Name
NM_001308142.2 NP_001295071.1 myocardin-related transcription factor B isoform 1
NM_001365411.2 NP_001352340.1 myocardin-related transcription factor B isoform 3
NM_001365412.2 NP_001352341.1 myocardin-related transcription factor B isoform 4
NM_001365413.2 NP_001352342.1 myocardin-related transcription factor B isoform 5
NM_001365414.2 NP_001352343.1 myocardin-related transcription factor B isoform 6
NM_001365415.2 NP_001352344.1 myocardin-related transcription factor B isoform 7
NM_001365416.2 NP_001352345.1 myocardin-related transcription factor B isoform 8
NM_001365417.3 NP_001352346.1 myocardin-related transcription factor B isoform 9
NM_001365418.3 NP_001352347.1 myocardin-related transcription factor B isoform 9
NM_001365419.3 NP_001352348.1 myocardin-related transcription factor B isoform 9
NM_001365420.3 NP_001352349.1 myocardin-related transcription factor B isoform 9
NM_001365421.3 NP_001352350.1 myocardin-related transcription factor B isoform 9
NM_014048.4 NP_054767.3 myocardin-related transcription factor B isoform 2
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
12397177 GOA
enables transcription coactivator activity IDA
IDA: 通过直接分析推断
14565952 GOA
enables transcription coactivator activity IGI
IGI: 通过遗传相互作用推断
23764775 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in positive regulation of miRNA transcription IGI
IGI: 通过遗传相互作用推断
23764775 GOA
involved in positive regulation of striated muscle tissue development IDA
IDA: 通过直接分析推断
14565952 GOA
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
14565952 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

MRTFB 蛋白结构

RPEL

RPEL: RPEL repeat (51 - 74)

RPEL

RPEL: RPEL repeat (95 - 119)

RPEL

RPEL: RPEL repeat (139 - 163)

SAP

SAP: SAP domain (401 - 433)

  • 0
  • 200
  • 400
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  • 800
  • 1049 a.a.
蛋白主名 其他名称

myocardin-related transcription factor B

CTA-276F8.1

MRTFB 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
MRTFB Q9ULH7 SRF Homo sapiens P11831
Affinity Techniques
14565952
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Chondroid Lipoma
Spondylometaphyseal Dysplasia, Sedaghatian Type

SMDS

Sedaghatian Chondrodysplasia

Spondylometaphyseal Dysplasia Sedaghatian Type

Congenital Lethal Metaphyseal Chondrodysplasia

Metaphyseal Chondrodysplasia, Congenital Lethal

Lethal Metaphyseal Dysplasia
Schizophrenia 12

Sczd12

Schizophrenia Susceptibility Locus, Chromosome 1p-Related
Left Ventricular Noncompaction

Noncompaction Cardiomyopathy

Left Ventricular Hypertrabeculation

Lvnc

Spongy Myocardium

Isolated Noncompaction Of The Ventricular Myocardium

Left Ventricular Myocardial Noncompaction Cardiomyopathy

Fetal Myocardium

Honeycomb Myocardium

Hypertrabeculation Syndrome

Left Ventricular Non-Compaction

Lvht

Non-Compaction Of The Left Ventricular Myocardium

Ventricular Noncompaction, Left

Non-Compaction Cardiomyopathy
Microcephaly

Microencephaly

Microcephalus

Microcephalic

Nanocephaly

Congenital Microcephaly

Brain Hypoplasia

Brain Nondevelopment

Cephalic Hypoplasia

Undeveloped Cerebrum

Undeveloped Brain

Micrencephalon

Micrencephaly
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS08694 MRTFB Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus MRTFB VGNC VGNC:31489
Felis catus MRTFB VGNC VGNC:63628
Canis familiaris MRTFB VGNC VGNC:43249
Mus musculus MRTFB MGD MGI:3050795
Rattus norvegicus MRTFB RGD RGD:1560833
Macaca mulatta MRTFB VGNC VGNC:74865
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