SRF - serum response factor Gene

中文名称：血清反应因子

种属: Homo sapiens

同用名: MCM1

基因 ID: 6722 | 基因类型: protein coding

关于 SRF

Cytogenetic location: 6p21.1 Genomic coordinates (GRCh38): 6:43,171,269-43,181,506 (from NCBI)

This gene has 1 transcript (splice variant), 279 orthologues and 4 paralogues. Ubiquitous expression in prostate (RPKM 20.2), heart (RPKM 19.8) and 25 other tissues.

功能概要

该基因编码一种普遍存在的核蛋白，可刺激细胞增殖和分化。它是 MADS (MCM1、Agamous、Deficiens 和 SRF) 转录因子盒超家族的成员。该蛋白与目标基因启动子区域的血清反应元件 (SRE) 结合。该蛋白调节许多即刻早期基因的活性，例如 c-Fos，从而参与细胞周期调节、细胞凋亡、细胞生长和细胞分化。该基因是许多途径的下游目标；例如，通过三元复合因子 (TCF) 起作用的丝裂原活化蛋白激酶通路 (MAPK) 。已发现该基因的两个转录本变体编码不同的亚型。[RefSeq 提供，2014 年 5 月]

This gene encodes a ubiquitous nuclear protein that stimulates both cell proliferation and differentiation. It is a member of the MADS (MCM1, Agamous, Deficiens, and SRF) box superfamily of transcription factors. This protein binds to the serum response element (SRE) in the promoter region of target genes. This protein regulates the activity of many immediate-early genes, for example c-Fos, and thereby participates in cell cycle regulation, Apoptosis, cell growth, and cell differentiation. This gene is the downstream target of many pathways; for example, the mitogen-activated protein kinase pathway (MAPK) that acts through the ternary complex factors (TCFs). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2014]

SRF 基因产物(2)

mRNA	Protein	Name
NM_001292001.2	NP_001278930.1	serum response factor isoform 2
NM_003131.4	NP_003122.1	serum response factor isoform 1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: 通过直接分析推断	20808827	GOA
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IGI IGI: 通过遗传相互作用推断	23764775	GOA
enables DNA-binding transcription factor activity	IDA IDA: 通过直接分析推断	3203386	GOA
enables DNA-binding transcription factor activity	IMP IMP: 通过突变表型推断	18296735	GOA
enables DNA-binding transcription factor binding	IPI IPI: 通过物理相互作用推断	16054032	GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: 通过直接分析推断	1509260	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	7854423	GOA
enables protein homodimerization activity	IPI IPI: 通过物理相互作用推断	3203386	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: 通过直接分析推断	28473536	GOA
enables serum response element binding	IDA IDA: 通过直接分析推断	3203386	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in cardiac muscle cell myoblast differentiation	IGI IGI: 通过遗传相互作用推断	19783823	GOA
involved in cell migration involved in sprouting angiogenesis	IMP IMP: 通过突变表型推断	15180964	GOA
involved in cellular senescence	IMP IMP: 通过突变表型推断	15282327	GOA
involved in negative regulation of amyloid-beta clearance	IMP IMP: 通过突变表型推断	19098903	GOA
involved in positive regulation of DNA-binding transcription factor activity	IDA IDA: 通过直接分析推断	19098903	GOA
involved in positive regulation of DNA-binding transcription factor activity	IMP IMP: 通过突变表型推断	18296735	GOA
acts upstream of or within positive regulation of cell differentiation	IDA IDA: 通过直接分析推断	17576768	GOA
involved in positive regulation of miRNA transcription	IGI IGI: 通过遗传相互作用推断	23764775	GOA
involved in positive regulation of smooth muscle contraction	IDA IDA: 通过直接分析推断	17215356	GOA
acts upstream of or within positive regulation of transcription by RNA polymerase II	IDA IDA: 通过直接分析推断	17576768	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: 通过直接分析推断	3203386	GOA
involved in positive regulation of transcription by RNA polymerase II	IGI IGI: 通过遗传相互作用推断	19783823	GOA
involved in positive regulation of transcription initiation by RNA polymerase II	IDA IDA: 通过直接分析推断	8887666	GOA
involved in response to cytokine	IMP IMP: 通过突变表型推断	15180964	GOA
involved in response to hormone	IDA IDA: 通过直接分析推断	17975004	GOA
involved in response to hypoxia	IEP IEP: 通过表达模式推断	19098903	GOA
acts upstream of or within trophectodermal cell differentiation	IDA IDA: 通过直接分析推断	17576768	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in nucleus	IDA IDA: 通过直接分析推断	2108863	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

SRF 蛋白结构

SRF-TF

0
100
200
300
400
508 a.a.

蛋白主名

其他名称

serum response factor

c-fos serum response element-binding transcription factor

SRF 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	SRF	P11831	GTF2F1	Homo sapiens	P35269	Y2H	7854423
种属内	SRF	P11831	MRTFB	Homo sapiens	Q9ULH7	Anti Tag CoIP	14565952
种属内	SRF	P11831	MRTFB	Homo sapiens	Q9ULH7	Pull Down	12397177
种属内	SRF	P11831	MRTFA	Homo sapiens	Q969V6	Pull Down	12397177
种属内	SRF	P11831	MYOCD	Homo sapiens	Q8IZQ8	Comig Non-Denat Gel	12397177

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Miller Fisher Syndrome

Cranial Variant Of Gbs	Fisher'S Syndrome
Miller-Fisher Variant Of Guillain-Barre Syndrome	Miller-Fisher Syndrome
Cranial Variant Of Guillain-Barré Syndrome	Cranial Variant Of Guillain-Barre Syndrome
Fisher Syndrome

Myopericytoma

Myofibroma

Lipoleiomyoma	Uterine Fibroids
Solitary Myofibromatosis	Myolipoma

Lymphangioleiomyomatosis

Lymphangiomyomatosis	LAM
Lung Lymphangioleiomyomatosis	Pulmonary Lymphangioleiomyomatosis
Lymphangioleiomyomatosis, Somatic	Lymphangio-Myomatosis

Muscle Hypertrophy

MSLHP	Hypertrophy
Hypertrophy, Muscle

Acute Megakaryocytic Leukemia

Acute Megakaryoblastic Leukemia	Acute Megakaryoblastic Leukaemia
Megakaryocytic Myelosis	Thrombocytic Leukaemia
Amkl	Aml M7
Acute Myeloblastic Leukemia Type 7	Acute Myeloid Leukemia M7
Megakaryoblastic Leukemia Acute	Leukemia, Megakaryoblastic, Acute
Acute Myeloid Leukaemia, M7	Acute Megakaryocytic Leukaemia
Acute Megakaryoblastic Leukaemia, Fab M7	Fab M7
Malignant Megakaryocytosis	M7 - Acute Megakaryoblastic Leukaemia
Megakaryoblastic Leukaemia	Megakaryocytic Leukaemia
Acute Megakaryoblastic Leukaemia, Nos	Acute Megakaryoblastic Leukaemia Without Mention Of Remission

Chondroid Lipoma

Megabladder, Congenital

MGBL	Congenital Megabladder

Rheumatoid Vasculitis

Brachydactyly, Type E1

Brachydactyly Type E1	Brachydactyly Type E
BDE1	Brachydactyly, Type E
Bde	Type E Brachydactyly
Brachydactyly E1	Brachydactyly Syndrome Type E

Skin Disease

Skin Diseases	Genodermatosis
Abnormality Of The Skin	Skin Diseases, Genetic
Skin And Subcutaneous Tissue Disease	Dermatologic Disorders

T-Cell Acute Lymphoblastic Leukemia

T-Cell Leukemia	Acute T Cell Leukemia
Precursor T Lymphoblastic Leukemia	Precursor T-Lymphoblastic Lymphoma/Leukemia
T Acute Lymphoblastic Leukemia	T-Cell Acute Lymphocytic Leukaemia
T-Cell Lymphoblastic Leukemia/Lymphoma	Leukemia T-Cell
Leukemia, T-Cell	Leukemia, Acute, Lymphoblastic, T-Cell
Leukemia, T-Cell Acute Lymphoblastic	Leukemia, Acute T-Cell
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	Precursor T-Cell Lymphoblastic Lymphoma
Precursor T Cell Lymphoblastic Leukemia/Lymphoblastic Lymphoma

Rheumatoid Arthritis

RA	Arthritis, Rheumatoid
Rheumatoid Arthritis, Susceptibility To	Arthritis Or Polyarthritis, Rheumatic
Atrophic Arthritis	Rheumatism Arthritis
Rheumatoid Polyarthritis

Polycystic Kidney Disease

Polycystic Kidney Diseases	Pkd
Polycystic Renal Disease	Kidney Disease, Polycystic
Polycystic Kidney, Autosomal Dominant

Heart Disease

Heart Failure	Congenital Heart Disease
Heart Diseases	Congenital Heart Defects
Congenital Heart Defect	Heart Malformation
Congenital Anomaly Of Heart	Heart Defect
Heart-Congenital Defect	Congenital Heart Disorder
Heart Defects Congenital	Heart Defects, Congenital
Heart Defects	Heart Disease, Congenital
Disease, Heart, Congenital	Congestive Heart Failure

Dyslexia

Systemic Lupus Erythematosus

Lupus Nephritis	SLE
Disseminated Lupus Erythematosus	Systemic Lupus Erythematosus, Susceptibility To
Lupus Erythematosus, Systemic	Lupus Nephritis, Susceptibility To
Libman-Sacks Disease	Systemic Lupus Erythematosus Susceptibility To
Sle - Lupus Erythematosus, Systemic	Le Syndrome
Lupus	Lupus Erythematosus Systemic
Lupus Erythematosus, Systemic, Susceptibility To	Lupus Vulgaris
Lupus Erythematosus, Discoid	Lupus Erythematosus
Systemic Lupus Erythematosus Nos	Sle - [Systemic Lupus Erythematosus]

Aortic Valve Disease 1

Aortic Valve Disease	Bicuspid Aortic Valve
Aortic Valve Disorder	AOVD1
Bav	Bicuspid Aortic Valve Disease
Familial Bicuspid Aortic Valve	Aortic Valve Calcification
Aovd	Aortic Valve, Bicuspid
Aortic Valve, Calcification Of	Aortic Stenosis, Calcific
Familial Bav	Calcific Aortic Stenosis
Calcification Of Aortic Valve	Abnormality Of The Aortic Valve
Aortic Valve Disease, Type 1	Aortic Valve Disease 2
Bicommissural Aortic Valve

Aortic Aneurysm, Familial Thoracic 1

Thoracic Aortic Aneurysm	Annuloaortic Ectasia
Familial Thoracic Aortic Aneurysm And Aortic Dissection	Familial Aortic Dissection
Familial Taad	Familial Thoracic Aortic Aneurysm
Congenital Aneurysm Of Ascending Aorta	Familial Aortic Aneurysm
Familial Thoracic Aortic Aneurysm And Dissection	Aortic Aneurysm, Thoracic
AAT1	Faa1
Aortic Dissection, Familial	Aortic Aneurysm, Familial Thoracic
Aneurysm, Thoracic Aortic	Faa
Ftaad	Taa
Taad	Cystic Medial Necrosis Of Aorta
Familial Non-Syndromic Thoracic Aortic Aneurysm And Aortic Dissection	Aortic Aneurysm Thoracic
Familial Aortic Aneurysms	Aneurysm, Aortic, Thoracic, Familial, Type 1
Aneurysm Of Thoracic Aorta	Intrathoracic Aneurysm
Thoracic Aorta Aneurysm	Thoracic Aortic Aneurysm Without Rupture
Thoracic Aneurysm	Thorax Arterial Aneurysm
Thoracic Artery Aneurysm	Thoracic Arterial Aneurysm
Thorax Aneurysm	Thorax Aortic Aneurysm
Dissection Of Thoracic Aorta

Dilated Cardiomyopathy

Familial Dilated Cardiomyopathy	Primary Dilated Cardiomyopathy
Idiopathic Dilated Cardiomyopathy	Congestive Cardiomyopathy
Idiopathic Dilation Cardiomyopathy	Primary Familial Dilated Cardiomyopathy
Cardiomyopathy, Dilated	DCM
Cardiomyopathy, Familial Dilated	Dilated Cardiomyopathy, Familial
Hypokinetic Dilated Cardiomyopathy, Familial	Familial Idiopathic Cardiomyopathy
Fdc	Cardiomyopathy, Familial Idiopathic
Idiopathic Cardiomegaly	Dilated Congestive Cardiomyopathy
Chronic Dilated Cardiomyopathy	Ccm - [Congestive Cardiomyopathy]
Cocm - [Congestive Cardiomyopathy]	Dcm - [Dilated Cardiomyopathy]
Dilated-Hypokinetic Cardiomyopathy	Congestive Idiopathic Cardiomyopathy
Primary Idiopathic Dilated Cardiomyopathy

Hypertrophic Cardiomyopathy

Hypertrophic Obstructive Cardiomyopathy	Cardiomyopathy, Hypertrophic
Cardiomyopathy Hypertrophic Obstructive	Cardiomyopathy, Hypertrophic, Familial
Idiopathic Myocardial Hypertrophy	Idiopathic Hypertrophic Cardiomyopathy
Obstructive Idiopathic Hypertrophic Cardiomyopathy	Obstructive Cardiomyopathy
Idiopathic Hypertrophic Subaortic Stenosis	Muscular Subaortic Stenosis
Hypertrophic Obstructive Subaortic Stenosis

Tetralogy Of Fallot

TOF	Fallot Tetralogy
Ventricular Septal Defect With Pulmonary Stenosis Or Atresia, Dextraposition Of Aorta, And Hypertrophy Of Right Ventricle	Tetrad Of Fallot
Fallot Tetrad	Fallot Disease
Fallot Complex	Subpulmonic Stenosis, Ventricular Septal Defect, Overriding Aorta, And Right Ventricular Hypertrophy
Interventricular Septal Defect With Dextroposition Of Aorta, Pulmonary Stenosis And Hypertrophy Of Right Ventricle	Interventricular Septal Defect, In Tetralogy Of Fallot
Ventricular Septal Defect With Obstructed Right Ventricular Outflow	Tof - [Tetralogy Of Fallot]
Pulmonary Atresia With Ventricular Septal Defect [Fallot Type]	Pulmonary Atresia, Ventricular Septal Defect And Mapcas
Pulmonary Atresia With Ventricular Septal Defect And Systemic-To-Pulmonary Collateral Arteries [Fallot Type]

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

目录号	产品名	作用方式	纯度	Phase
HY-P990024	Casdozokitug	Inhibitor	96.49%	Phase 2
HY-P99533	Urabrelimab	Inhibitor	98.49%	Phase 1

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-13991	CCG-1423		99.94%	否
HY-108361	CCG-203971	Inhibitor	≥98.0%	否
HY-120855	CCG-100602	Inhibitor	99.85%	否
HY-153078	MRTF/SRF-IN-1	Inhibitor	99.68%	否
HY-111432	CCG-232601	Inhibitor	99.00%	否
HY-118748	Suprafenacine	Inhibitor	≥98.0%	否
HY-130011	CCG-232964	Inhibitor	/	否
HY-162904	BPU17		/	否
HY-162968	MRTF-A-IN-1	Inhibitor	/	否
HY-162969	MRTF-A-IN-2	Inhibitor	/	否
HY-RS13760	SRF Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Rattus norvegicus	SRF	RGD	RGD:1559787
Mus musculus	SRF	MGD	MGI:106658
Macaca mulatta	SRF	VGNC	VGNC:77882
Canis familiaris	SRF	VGNC	VGNC:46799
Bos taurus	SRF	VGNC	VGNC:35277
Felis catus	SRF	VGNC	VGNC:65678
Others	SRF	NCBI

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。	站点地图隐私声明
沪ICP备15051369号-4 上海工商沪公网安备31011502019417 沪(浦)应急管危经许[2021]201709(QFYS) 营业执照（三证合一）
Copyright © 2013-2025 MedChemExpress. All Rights Reserved.

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

SRF - serum response factor Gene

关于 SRF

功能概要

SRF 基因产物(2)

SRF 蛋白结构

SRF 蛋白互作信息

关联疾病

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

姓名
邮箱 *

Sorry, but the email address you supplied was invalid.

SRF - serum response factor Gene

关于 SRF

功能概要

SRF 基因产物(2)

SRF 蛋白结构

SRF 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z