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  2. MTA3 - metastasis associated 1 family member 3 Gene

MTA3 - metastasis associated 1 family member 3 Gene

中文名称:转移相关 1 家族成员 3

种属: Homo sapiens

基因 ID: 57504 | 基因类型: protein coding

关于 MTA3

Cytogenetic location: 2p21 Genomic coordinates (GRCh38): 2:42,494,110-42,756,946 (from NCBI)

This gene has 19 transcripts (splice variants), 209 orthologues and 5 paralogues. Ubiquitous expression in brain (RPKM 6.3), ovary (RPKM 5.7) and 24 other tissues.

功能概要

预测启用组蛋白脱乙酰酶结合活性;转录共激活因子活性;和转录辅阻遏物活性。参与转录的负调控,以 DNA 为模板。位于核质中。 NuRD 复合体的一部分。 [由基因组资源联盟提供,2022 年 4 月]

Predicted to enable histone deacetylase binding activity; transcription coactivator activity; and transcription corepressor activity. Involved in negative regulation of transcription, DNA-templated. Located in nucleoplasm. Part of NuRD complex. [provided by Alliance of Genome Resources, Apr 2022]

MTA3 基因产物(6)

mRNA Protein Name
NM_001282755.2 NP_001269684.1 metastasis-associated protein MTA3 isoform a
NM_001282756.2 NP_001269685.1 metastasis-associated protein MTA3 isoform a
NM_001330442.2 NP_001317371.1 metastasis-associated protein MTA3 isoform c
NM_001330443.2 NP_001317372.1 metastasis-associated protein MTA3 isoform d
NM_001330444.2 NP_001317373.1 metastasis-associated protein MTA3 isoform e
NM_020744.4 NP_065795.1 metastasis-associated protein MTA3 isoform b
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
22926524 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in chromatin remodeling IDA
IDA: 通过直接分析推断
9790534 GOA
involved in negative regulation of DNA-templated transcription IMP
IMP: 通过突变表型推断
15454082 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of NuRD complex IDA
IDA: 通过直接分析推断
22926524 GOA
located in nucleus IDA
IDA: 通过直接分析推断
28977666 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

MTA3 蛋白结构

BAH

BAH: BAH domain (4 - 147)

ELM2

ELM2: ELM2 domain (150 - 202)

GATA

GATA: GATA zinc finger (379 - 415)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 594 a.a.
蛋白主名 其他名称

metastasis-associated protein MTA3

metastasis associated gene family, member 3

MTA3 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
MTA3 Q9BTC8 GATA3 Homo sapiens P23771
Anti Bait CoIP
26028330
种属内
MTA3 Q9BTC8 GATA3 Homo sapiens P23771
Anti Tag CoIP
26028330
种属内
MTA3 Q9BTC8 GATA3 Homo sapiens P23771
CH-IP
26028330
种属内
MTA3 Q9BTC8 EHMT2 Homo sapiens Q96KQ7
Anti Tag CoIP
26028330
种属内
MTA3 Q9BTC8 EHMT2 Homo sapiens Q96KQ7
Pull Down
26028330
种属内
MTA3 Q9BTC8 EHMT2 Homo sapiens Q96KQ7
Anti Bait CoIP
26028330
种属内
MTA3 Q9BTC8 EHMT2 Homo sapiens Q96KQ7
CH-IP
26028330
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Pyloric Stenosis
Hutchinson-Gilford Progeria Syndrome

Progeria

HGPS

Hutchinson-Gilford Syndrome

Hutchinson-Gilford Progeria

Hutchinson Gilford Syndrome

Hutchinson Gilford Progeria Syndrome

Hutchinson-Gilford Disease

Progeria Of Childhood

Hutchinson-Gilford-Progeria Syndrome

Hypertrophic Pyloric Stenosis

Congenital Hypertrophic Pyloric Stenosis

Pyloric Stenosis, Hypertrophic

Congenital Or Infantile Stricture Of Pylorus

Achalasia Of The Pylorus

Congenital Hypertrophy Of The Pylorus

Infantile Hypertrophy Of The Pylorus

Infantile Constriction Of The Pylorus

Congenital Stenosis Of The Pylorus

Congenital Constriction Of The Pylorus

Congenital Stricture Of The Pylorus

Infantile Hypertrophic Pyloric Stenosis

Infantile Stenosis Of The Pylorus

Infantile Stricture Of The Pylorus

Congenital Or Infantile Constriction Of Pylorus

Infantile Pyloric Obstruction

Infantile Pyloric Hypertrophy

Pylorus Achalasia

Pyloric Constriction

Infantile Pyloric Stricture

Infantile Pyloric Stenosis

Congenital Spasm Of Pylorus

Congenital Pylorospasm

Congenital Pyloric Stricture

Congenital Pyloric Spasm

Congenital Or Infantile Spasm Of Pylorus

Congenital Or Infantile Obstruction Of Pylorus

Congenital Pyloric Stenosis

Breast Cancer

Breast Carcinoma

Male Breast Cancer

Breast Cancer, Familial

Malignant Neoplasm Of Breast

Breast Cancer, Susceptibility To

Breast Cancer, Early-Onset

Malignant Tumor Of Breast

Carcinoma Of Male Breast

Breast Cancer, Invasive Ductal

Breast Cancer, Protection Against

Breast Cancer, Somatic

Breast Cancer, Male

Breast Cancer, Lobular, Somatic

Breast Tumor

Mammary Cancer

Mammary Tumor

Malignant Neoplasm Of Male Breast

Mammary Carcinoma

Male Breast Carcinoma

Familial Cancer Of Breast

Invasive Ductal Breast Carcinoma

Breast Cancer Susceptibility

Breast Cancer, Male, Susceptibility To

Breast Cancer, Early-Onset, Susceptibility To

Malignant Tumor Of The Breast

Mammary Neoplasm

Primary Breast Cancer

Neoplasm Of Male Breast

Carcinoma Of Breast

Breast Cancer In Men

Familial Breast Cancer

Cancer Of Breast

BC

Breast Cancer Familial

Breast Cancer Familial Male

Breast Cancer, Familial Male

Breast Male Carcinoma

Breast Neoplasms

Breast Neoplasms, Male

Mammary Tumors

Mammary Carcinomas

Cancer, Breast

Cancer, Breast, Susceptibility

Invasive Breast Ductal Carcinoma

Breast Neoplasm

Susceptibility To Breast Cancer

Mammary Neoplasms

Animal Mammary Neoplasms

Primary Malignant Neoplasm Of Breast

Infiltrating Ductal Carcinoma Of Breast

Infiltrating Duct Carcinoma Of Unspecified Site

Infiltrating Ductular Carcinoma Of Unspecified Site

Invasive Breast Carcinoma Of No Special Type

Microinvasive Carcinoma Of Breast

Carcinoma With Apocrine Differentiation

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Bos taurus MTA3 VGNC VGNC:31715
Macaca mulatta MTA3 VGNC VGNC:74814
Felis catus MTA3 VGNC VGNC:63640
Rattus norvegicus MTA3 RGD RGD:1306803
Mus musculus MTA3 MGD MGI:2151172