PREX1 - phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1 Gene

中文名称：磷脂酰肌醇 3,4,5-三磷酸依赖性 Rac 交换因子 1

种属: Homo sapiens

同用名: P-REX1

关于 PREX1

功能概要

由该基因编码的蛋白质充当小 GTP 结合蛋白 (RAC) RHO 家族的鸟嘌呤核苷酸交换因子。它已被证明可以通过将绑定的 GDP 换成免费的 GTP 来绑定并激活 RAC1。编码的蛋白质主要存在于细胞质中，被磷脂酰肌醇-3,4,5-三磷酸和异源三聚体 G 蛋白的 β-γ 亚基激活。[RefSeq 提供，2008 年 7 月]

The protein encoded by this gene acts as a guanine nucleotide exchange factor for the RHO family of small GTP-binding proteins (RACs). It has been shown to bind to and activate RAC1 by exchanging bound GDP for free GTP. The encoded protein, which is found mainly in the cytoplasm, is activated by phosphatidylinositol-3,4,5-trisphosphate and the beta-gamma subunits of heterotrimeric G proteins. [provided by RefSeq, Jul 2008]