2. Gene
  3. VPS18 - VPS18 core subunit of CORVET and HOPS complexes Gene

VPS18 - VPS18 core subunit of CORVET and HOPS complexes Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：CORVET 和 HOPS 复合体的 VPS18 核心亚基

种属: Homo sapiens

同用名: PEP3

基因 ID: 57617 | 基因类型: protein coding

关于 VPS18

Cytogenetic location: 15q15.1 Genomic coordinates (GRCh38): 15:40,894,450-40,903,975 (from NCBI)

This gene has 3 transcripts (splice variants), 200 orthologues and 1 paralogue. Ubiquitous expression in bone marrow (RPKM 7.7), kidney (RPKM 5.8) and 25 other tissues.

功能概要

囊泡介导的蛋白质分选在将细胞内分子分离到不同的细胞器中起着重要作用。酵母的遗传研究已经确定了 40 多个液泡蛋白分选 (VPS) 基因参与囊泡向液泡的运输。该基因编码酵母 C 类 Vps18 蛋白的人类同系物。哺乳动物 C 类 Vps 蛋白主要与晚期内体/溶酶体相关，并且像它们的酵母对应物一样，可能介导内体/溶酶体途径中的囊泡运输步骤。[RefSeq 提供，2008 年 7 月]

Vesicle mediated protein sorting plays an important role in segregation of intracellular molecules into distinct organelles. Genetic studies in yeast have identified more than 40 vacuolar protein sorting (VPS) genes involved in vesicle transport to vacuoles. This gene encodes the human homolog of yeast class C Vps18 protein. The mammalian class C Vps proteins are predominantly associated with late endosomes/lysosomes, and like their yeast counterparts, may mediate vesicle trafficking steps in the endosome/lysosome pathway. [provided by RefSeq, Jul 2008]

VPS18 基因产物(1)

mRNA Protein Name
NM_020857.3 NP_065908.1 vacuolar protein sorting-associated protein 18 homolog

VPS18 蛋白结构

Pep3_Vps18

Pep3_Vps18: Pep3/Vps18/deep orange family (291 - 435)

Clathrin

Clathrin: Region in Clathrin and VPS (640 - 768)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 973 a.a.
蛋白主名 其他名称

vacuolar protein sorting-associated protein 18 homolog

VPS18, CORVET/HOPS core subunit

VPS18 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra VPS18 Q9P253 VPS39 Homo sapiens Q96JC1
Anti Tag CoIP
33422265
Intra VPS18 Q9P253 VPS41 Homo sapiens P49754
Y2H
23901104
Intra VPS18 Q9P253 VPS41 Homo sapiens P49754
Anti Tag CoIP
33422265
Intra VPS18 Q9P253 VPS41 Homo sapiens P49754
Anti Tag CoIP
26496610
Intra VPS18 Q9P253 VPS33A Homo sapiens Q96AX1
Anti Tag CoIP
26496610
Intra VPS18 Q9P253 VPS33A Homo sapiens Q96AX1
Anti Bait CoIP
25783203
Intra VPS18 Q9P253 MON1B Homo sapiens Q7L1V2
Y2H
20434987
Intra VPS18 Q9P253 MON1B Homo sapiens Q7L1V2
Pull Down
20434987
Intra VPS18 Q9P253 VPS16 Homo sapiens Q9H269
Anti Bait CoIP
25783203
Intra VPS18 Q9P253 VPS16 Homo sapiens Q9H269
Anti Bait CoIP
11382755
Intra VPS18 Q9P253 VPS16 Homo sapiens Q9H269
Anti Tag CoIP
26496610
Intra VPS18 Q9P253 VPS11 Homo sapiens Q9H270
Anti Bait CoIP
11382755
Intra VPS18 Q9P253 VPS11 Homo sapiens Q9H270
Anti Tag CoIP
26496610
Cross VPS18 Q9P253 Vps33a Rattus norvegicus Q63615
Anti Tag CoIP
11382755
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Hermansky-Pudlak Syndrome

Hps

Albinism With Hemorrhagic Diathesis And Pigmented Reticuloendothelial Cells

Hermanski-Pudlak Syndrome

Hermansky Pudlak Syndrome

Platelet Storage Pool Deficiency
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS15677 VPS18 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus VPS18 RGD RGD:1311556
Canis familiaris VPS18 VGNC VGNC:48279
Mus musculus VPS18 MGD MGI:2443626
Felis catus VPS18 VGNC VGNC:66959
Macaca mulatta VPS18 VGNC VGNC:78999
Bos taurus VPS18 VGNC VGNC:36812
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