VPS18 - VPS18 core subunit of CORVET and HOPS complexes Gene

中文名称：CORVET 和 HOPS 复合体的 VPS18 核心亚基

种属: Homo sapiens

同用名: PEP3

关于 VPS18

功能概要

囊泡介导的蛋白质分选在将细胞内分子分离到不同的细胞器中起着重要作用。酵母的遗传研究已经确定了 40 多个液泡蛋白分选 (VPS) 基因参与囊泡向液泡的运输。该基因编码酵母 C 类 Vps18 蛋白的人类同系物。哺乳动物 C 类 Vps 蛋白主要与晚期内体/溶酶体相关，并且像它们的酵母对应物一样，可能介导内体/溶酶体途径中的囊泡运输步骤。[RefSeq 提供，2008 年 7 月]

Vesicle mediated protein sorting plays an important role in segregation of intracellular molecules into distinct organelles. Genetic studies in yeast have identified more than 40 vacuolar protein sorting (VPS) genes involved in vesicle transport to vacuoles. This gene encodes the human homolog of yeast class C Vps18 protein. The mammalian class C Vps proteins are predominantly associated with late endosomes/lysosomes, and like their yeast counterparts, may mediate vesicle trafficking steps in the endosome/lysosome pathway. [provided by RefSeq, Jul 2008]