VPS16 - VPS16 core subunit of CORVET and HOPS complexes Gene

中文名称：CORVET 和 HOPS 复合体的 VPS16 核心亚基

种属: Homo sapiens

同用名: DYT30; hVPS16

基因 ID: 64601 | 基因类型: protein coding

关于 VPS16

Cytogenetic location: 20p13 Genomic coordinates (GRCh38): 20:2,840,745-2,866,732 (from NCBI)

This gene has 8 transcripts (splice variants), 199 orthologues and is associated with 1 phenotype. Ubiquitous expression in appendix (RPKM 12.2), thyroid (RPKM 11.8) and 25 other tissues.

功能概要

囊泡介导的蛋白质分选在将细胞内分子分离到不同的细胞器中起着重要作用。酵母的遗传研究已经确定了 40 多个液泡蛋白分选 (VPS) 基因参与囊泡向液泡的运输。该基因编码酵母 C 类 Vps16 蛋白的人类同系物。哺乳动物 C 类 Vps 蛋白主要与晚期内体/溶酶体相关，并且像它们的酵母对应物一样，可能介导内体/溶酶体途径中的囊泡运输步骤。已发现该基因的两个转录本变体编码不同的亚型。[RefSeq 提供，2009 年 7 月]

Vesicle mediated protein sorting plays an important role in segregation of intracellular molecules into distinct organelles. Genetic studies in yeast have identified more than 40 vacuolar protein sorting (VPS) genes involved in vesicle transport to vacuoles. This gene encodes the human homolog of yeast class C Vps16 protein. The mammalian class C Vps proteins are predominantly associated with late endosomes/lysosomes, and like their yeast counterparts, may mediate vesicle trafficking steps in the endosome/lysosome pathway. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2009]

VPS16 基因产物(2)

mRNA	Protein	Name
NM_022575.4	NP_072097.2	vacuolar protein sorting-associated protein 16 homolog isoform 1
NM_080413.3	NP_536338.1	vacuolar protein sorting-associated protein 16 homolog isoform 3

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	11382755	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in autophagosome maturation	IMP IMP: 通过突变表型推断	25783203	GOA
involved in endosome to lysosome transport	IMP IMP: 通过突变表型推断	25783203	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of HOPS complex	IDA IDA: 通过直接分析推断	19109425	GOA
located in early endosome	IDA IDA: 通过直接分析推断	19109425	GOA
located in late endosome	IDA IDA: 通过直接分析推断	11382755	GOA
located in lysosome	IDA IDA: 通过直接分析推断	11382755	GOA
located in recycling endosome	IDA IDA: 通过直接分析推断	19109425	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

VPS16 蛋白结构

Vps16_N

Vps16_C

0
200
400
600
839 a.a.

蛋白主名

其他名称

vacuolar protein sorting-associated protein 16 homolog

VPS16, CORVET/HOPS core subunit

VPS16 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
Intra	VPS16	Q9H269	VPS18	Homo sapiens	Q9P253	Anti Tag CoIP	25783203
Intra	VPS16	Q9H269	VPS18	Homo sapiens	Q9P253	Anti Bait CoIP	11382755
Intra	VPS16	Q9H269	VPS18	Homo sapiens	Q9P253	Anti Tag CoIP	23901104
Intra	VPS16	Q9H269	VPS18	Homo sapiens	Q9P253	Y2H	23901104
Intra	VPS16	Q9H269	VPS18	Homo sapiens	Q9P253	Anti Tag CoIP	26496610
Intra	VPS16	Q9H269	VPS33A	Homo sapiens	Q96AX1	Anti Tag CoIP	25783203
Intra	VPS16	Q9H269	VPS33A	Homo sapiens	Q96AX1	Anti Tag CoIP	35271311
Intra	VPS16	Q9H269	VPS33A	Homo sapiens	Q96AX1	Pull Down	23901104
Intra	VPS16	Q9H269	VPS33A	Homo sapiens	Q96AX1	Anti Tag CoIP	33961781
Intra	VPS16	Q9H269	VPS33A	Homo sapiens	Q96AX1	Anti Tag CoIP	26496610
Intra	VPS16	Q9H269	VPS33A	Homo sapiens	Q96AX1	Anti Tag CoIP	33422265
Intra	VPS16	Q9H269	VPS33A	Homo sapiens	Q96AX1	Anti Tag CoIP	23901104
Intra	VPS16	Q9H269	STX17	Homo sapiens	P56962	Anti Tag CoIP	24554770
Intra	VPS16	Q9H269	TGFBRAP1	Homo sapiens	Q8WUH2	Anti Tag CoIP	26496610
Intra	VPS16	Q9H269	VPS11	Homo sapiens	Q9H270	Anti Tag CoIP	26496610
Intra	VPS16	Q9H269	VPS11	Homo sapiens	Q9H270	Anti Tag CoIP	35271311
Intra	VPS16	Q9H269	VPS11	Homo sapiens	Q9H270	Y2H	23901104
Intra	VPS16	Q9H269	VPS11	Homo sapiens	Q9H270	Anti Bait CoIP	11382755

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Dystonia 30

DYT30

Dystonia

Dystonic Disease	Dystonic Disorder
Dystonia Disorders	Neuroleptic Dyskinesia

Smith-Mccort Dysplasia 1

Smith-Mccort Dysplasia	SMC1
Smc	Smith Mccort Dysplasia
Smith-Mccort Dwarfism

Neuropathy, Hereditary Sensory And Autonomic, Type Iia

Hereditary Sensory And Autonomic Neuropathy Type 2	Hsan2
HSAN2A	Morvan Disease
Hereditary Sensory And Autonomic Neuropathy Type Ii	Neurogenic Acroosteolysis
Hsan Iia	Hsn2a
Hsn Iia	Neuropathy, Progressive Sensory, Of Children
Neuropathy, Congenital Sensory	Neuropathy, Hereditary Sensory And Autonomic, Type Ii
Hereditary Sensory And Autonomic Neuropathy Type 2a	Hereditary Sensory And Autonomic Neuropathy Type Iia
Hsanii	Congenital Sensory Neuropathy
Hsan Type Ii	Morvan Syndrome
Neuropathy, Hereditary Sensory And Autonomic, Type 2a	Morvan'S Disease
Neuropathy, Hereditary Sensory, Type Iia	Acroosteolysis, Neurogenic
Acroosteolysis, Giaccai Type	Neuropathy, Hereditary Sensory Radicular, Autosomal Recessive
Hereditary Sensory Autonomic Neuropathy Type 2	Giaccai Type Acroosteolysis
Hereditary Sensory Neuropathy Type 2	Hereditary Sensory Radicular Neuropathy, Recessive Form
Hsan2b	Hsan2c
Hsan2d	Hsn Type Ii
Autosomal Recessive Sensory Radicular Neuropathy	Limbic Encephalitis-Neuromyotonia-Hyperhidrosis-Polyneuropathy Syndrome
Morvan Fibrillary Chorea	Neuropathy, Hereditary Sensory And Autonomic, 2a
Acroosteolysis Giaccai Type	Hereditary Sensory Neuropathy Type Iia
Hereditary Sensory Radicular Neuropathy Autosomal Recessive	Progressive Sensory Neuropathy Of Children
Neuropathy Congenital Sensory	Charcot-Marie-Tooth Disease
Neuropathy, Sensory And Autonomic, Hereditary, Type Iia	Hereditary Sensory Autonomic Neuropathy, Type 2
Hereditary Motor And Sensory-Neuropathy Type Ii	Sensory Neuropathy, Hereditary
Neuropathy, Hereditary Sensory And Autonomic, Type Iib

Arthrogryposis, Renal Dysfunction, And Cholestasis 1

Arc Syndrome	ARCS1
Arthrogryposis Renal Dysfunction Cholestasis Syndrome	Arthrogryposis-Renal Dysfunction-Cholestasis Syndrome
Arcs	Arthrogryposis, Renal Dysfunction And Cholestasis Syndrome
Arthrogryposis, Renal Dysfunction, And Cholestasis	Arthrogryposis-Renal Dysfunction-Cholestasis
Arthrogryposis - Renal Dysfunction - Cholestasis	Arthrogryposis Multiplex Congenita, Renal Dysfunction, And Cholestasis
Arthrogryposis, Renal Dysfunction And Cholestasis Syndrome 1	Arthrogryposis Renal Dysfunction And Cholestasis 1
Arthrogryposis With Renal Dysfunction And Cholestasis Syndrome	Arthrogryposis, Renal Dysfunction, Cholestasis, Type 1
Kidney Failure	Renal Insufficiency

Dyggve-Melchior-Clausen Disease

Dyggve-Melchior-Clausen Syndrome	DMC
Dmc Disease	Pseudo-Morquio Disease Type I
Dmc Syndrome

Hermansky-Pudlak Syndrome

Hps	Albinism With Hemorrhagic Diathesis And Pigmented Reticuloendothelial Cells
Hermanski-Pudlak Syndrome	Hermansky Pudlak Syndrome
Platelet Storage Pool Deficiency

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS15676	VPS16 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Felis catus	VPS16	VGNC	VGNC:66958
Rattus norvegicus	VPS16	RGD	RGD:1359414
Bos taurus	VPS16	VGNC	VGNC:36811
Mus musculus	VPS16	MGD	MGI:2136772
Canis familiaris	VPS16	VGNC	VGNC:48278
Macaca mulatta	VPS16	VGNC	VGNC:78966

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。	站点地图隐私声明
沪ICP备15051369号-4 上海工商沪公网安备31011502019417 沪(浦)应急管危经许[2021]201709(QFYS) 营业执照（三证合一）
Copyright © 2013-2024 MedChemExpress. All Rights Reserved.

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

VPS16 - VPS16 core subunit of CORVET and HOPS complexes Gene

关于 VPS16

功能概要

VPS16 基因产物(2)

VPS16 蛋白结构

VPS16 蛋白互作信息

关联疾病

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

姓名
邮箱 *

Sorry, but the email address you supplied was invalid.

VPS16 - VPS16 core subunit of CORVET and HOPS complexes Gene

关于 VPS16

功能概要

VPS16 基因产物(2)

VPS16 蛋白结构

VPS16 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z