STX17 - syntaxin 17 Gene

中文名称：syntaxin 17

种属: Homo sapiens

基因 ID: 55014 | 基因类型: protein coding

关于 STX17

Cytogenetic location: 9q31.1 Genomic coordinates (GRCh38): 9:99,906,654-99,974,534 (from NCBI)

This gene has 12 transcripts (splice variants), 169 orthologues and 12 paralogues. Ubiquitous expression in thyroid (RPKM 7.7), skin (RPKM 7.1) and 25 other tissues.

功能概要

启用 SNAP 受体活性； SNARE 绑定活动；和蛋白磷酸酶结合活性。参与多个过程，包括自噬体膜对接；内质网到高尔基体囊泡介导的运输；和内质网-高尔基中间室组织。在蛋白质定位到吞噬泡组装位点的上游或内部起作用。位于多种细胞成分中，包括自噬体膜；内质网-高尔基中间室；和线粒体相关的内质网膜。 SNARE 复合体的一部分。与 HOPS 复合体共定位。 [由基因组资源联盟提供，2022 年 4 月]

Enables SNAP receptor activity; SNARE binding activity; and protein Phosphatase binding activity. Involved in several processes, including autophagosome membrane docking; endoplasmic reticulum to Golgi vesicle-mediated transport; and endoplasmic reticulum-Golgi intermediate compartment organization. Acts upstream of or within protein localization to phagophore assembly site. Located in several cellular components, including autophagosome membrane; endoplasmic reticulum-Golgi intermediate compartment; and mitochondria-associated endoplasmic reticulum membrane. Part of SNARE complex. Colocalizes with HOPS complex. [provided by Alliance of Genome Resources, Apr 2022]

STX17 基因产物(1)

mRNA	Protein	Name
NM_017919.3	NP_060389.2	syntaxin-17

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables SNAP receptor activity	IMP IMP: 通过突变表型推断	23217709	GOA
enables SNARE binding	IDA IDA: 通过直接分析推断	23217709	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	23217709	GOA
enables protein phosphatase binding	IPI IPI: 通过物理相互作用推断	23006999	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in Golgi organization	IMP IMP: 通过突变表型推断	21545355	GOA
involved in autophagosome maturation	IDA IDA: 通过直接分析推断	28306502	GOA
involved in autophagosome maturation	IMP IMP: 通过突变表型推断	23217709	GOA
involved in autophagosome membrane docking	IDA IDA: 通过直接分析推断	25686604	GOA
involved in endoplasmic reticulum to Golgi vesicle-mediated transport	IMP IMP: 通过突变表型推断	21545355	GOA
involved in endoplasmic reticulum-Golgi intermediate compartment organization	IMP IMP: 通过突变表型推断	21545355	GOA
acts upstream of or within protein localization to phagophore assembly site	IDA IDA: 通过直接分析推断	23455425	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of HOPS complex	IDA IDA: 通过直接分析推断	24554770	GOA
part of SNARE complex	IDA IDA: 通过直接分析推断	23217709	GOA
located in autophagosome	IDA IDA: 通过直接分析推断	25686604	GOA
located in autophagosome membrane	IDA IDA: 通过直接分析推断	23217709	GOA
located in endoplasmic reticulum membrane	IDA IDA: 通过直接分析推断	23217709	GOA
located in endoplasmic reticulum-Golgi intermediate compartment	IDA IDA: 通过直接分析推断	23006999	GOA
NOT located in lysosomal membrane	IDA IDA: 通过直接分析推断	10930465	GOA
located in mitochondria-associated endoplasmic reticulum membrane contact site	IDA IDA: 通过直接分析推断	23455425	GOA
NOT located in mitochondrion	IDA IDA: 通过直接分析推断	10930465	GOA
located in mitochondrion	IDA IDA: 通过直接分析推断	23217709	GOA
NOT located in rough endoplasmic reticulum	IDA IDA: 通过直接分析推断	10930465	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

STX17 蛋白结构

SNARE

0
100
200
302 a.a.

蛋白主名

其他名称

syntaxin-17

STX17 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
Intra	STX17	P56962	ACSL3	Homo sapiens	O95573	Anti Tag CoIP	29549094
Intra	STX17	P56962	ACSL3	Homo sapiens	O95573	PLA	29549094
Intra	STX17	P56962	VPS41	Homo sapiens	P49754	Anti Tag CoIP	24554770
Intra	STX17	P56962	VPS33A	Homo sapiens	Q96AX1	Anti Tag CoIP	24554770
Intra	STX17	P56962	VPS16	Homo sapiens	Q9H269	Anti Tag CoIP	24554770
Intra	STX17	P56962	VPS16	Homo sapiens	Q9H269	Confocal	24554770
Intra	STX17	P56962	SNAP29	Homo sapiens	O95721	Anti Tag CoIP	25419848
Intra	STX17	P56962	SNAP29	Homo sapiens	O95721	Anti Tag CoIP	23217709
Intra	STX17	P56962	SNAP29	Homo sapiens	O95721	Anti Bait CoIP	25419848
Intra	STX17	P56962	SNAP29	Homo sapiens	O95721	Anti Tag CoIP	33422265
Cross	STX17	P56962	Vamp7	Mus musculus	P70280	Anti Tag CoIP	23217709
Intra	STX17	P56962	VAMP8	Homo sapiens	Q9BV40	Anti Tag CoIP	23217709
Intra	STX17	P56962	VAMP8	Homo sapiens	Q9BV40	Anti Bait CoIP	25419848
Intra	STX17	P56962	VAMP8	Homo sapiens	Q9BV40	Anti Tag CoIP	33422265
Intra	STX17	P56962	VAMP8	Homo sapiens	Q9BV40	Anti Tag CoIP	25419848

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Melanomatosis

Vici Syndrome

Absent Corpus Callosum Cataract Immunodeficiency	VICIS
Immunodeficiency With Cleft Lip/Palate, Cataract, Hypopigmentation, And Absent Corpus Callosum	Dionisi Vici Sabetta Gambarara Syndrome
Immunodeficiency With Cleft Lip/Palate, Cataract, Hypopigmentation And Absent Corpus Callosum	Corpus Callosum Agenesis-Cataract-Immunodeficiency Syndrome
Dionisi-Vici-Sabetta-Gambarara Syndrome	Immunodeficiency With Cleft Lip/Palate Cataract Hypopigmentation And Absent Corpus Callosum

Alopecia Areata

Aa	Alopecia Celsi
Alopecia Circumscripta	Cazenave'S Vitiligo
Celsus' Vitiligo	Diffuse Alopecia
Jonston'S Alopecia	Marginal Alopecia
Pseudopelade	Circumscribed Alopecia
Alopecia Cicatrisata	Patchy Alopecia
Alopecia	Aa - [Alopecia Areata]
Pelade

Alopecia Universalis Congenita

Alopecia Universalis	ALUNC
Atrichia, Generalized	Au
Alopecia Areata Universalis	Atrichia Generalized

Pontiac Fever

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-129111	EACC	Inhibitor	99.72%	否
HY-152100	CUR5g	Inhibitor	98.69%	否
HY-RS13978	STX17 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Mus musculus	STX17	MGD	MGI:1914977
Rattus norvegicus	STX17	RGD	RGD:708499
Macaca mulatta	STX17	VGNC	VGNC:78042
Felis catus	STX17	VGNC	VGNC:65808
Bos taurus	STX17	VGNC	VGNC:35433
Canis familiaris	STX17	VGNC	VGNC:46951

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

STX17 - syntaxin 17 Gene

关于 STX17

功能概要

STX17 基因产物(1)

STX17 蛋白结构

STX17 蛋白互作信息

关联疾病

直系同源

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STX17 - syntaxin 17 Gene

关于 STX17

功能概要

STX17 基因产物(1)

STX17 蛋白结构

STX17 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z