VAMP8 - vesicle associated membrane protein 8 Gene

中文名称：囊泡相关膜蛋白 8

种属: Homo sapiens

同用名: EDB; VAMP-8

基因 ID: 8673 | 基因类型: protein coding

关于 VAMP8

Cytogenetic location: 2p11.2 Genomic coordinates (GRCh38): 2:85,577,586-85,582,031 (from NCBI)

This gene has 3 transcripts (splice variants), 187 orthologues and 10 paralogues. Ubiquitous expression in colon (RPKM 79.3), placenta (RPKM 77.9) and 24 other tissues.

功能概要

该基因编码一种完整的膜蛋白，属于可溶性 N-乙基马来酰亚胺敏感因子附着蛋白受体 (SNARE) 的突触小蛋白/囊泡相关膜蛋白亚家族。编码的蛋白质参与突触小泡与突触前膜的融合。[RefSeq 提供，2010 年 6 月]

This gene encodes an integral membrane protein that belongs to the synaptobrevin/vesicle-associated membrane protein subfamily of soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNAREs). The encoded protein is involved in the fusion of synaptic vesicles with the presynaptic membrane.[provided by RefSeq, Jun 2010]

VAMP8 基因产物(1)

mRNA	Protein	Name
NM_003761.5	NP_003752.2	vesicle-associated membrane protein 8

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables chloride channel inhibitor activity	IDA IDA: 通过直接分析推断	18570918	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	19557002	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in autophagosome maturation	IMP IMP: 通过突变表型推断	23217709	GOA
involved in autophagosome membrane docking	IDA IDA: 通过直接分析推断	25686604	GOA
NOT involved in eosinophil degranulation	IMP IMP: 通过突变表型推断	16677249	GOA
involved in mucus secretion	IMP IMP: 通过突变表型推断	22144578	GOA
involved in negative regulation of secretion by cell	IDA IDA: 通过直接分析推断	12130530	GOA
NOT involved in neutrophil degranulation	IMP IMP: 通过突变表型推断	16677249	GOA
involved in positive regulation of histamine secretion by mast cell	IMP IMP: 通过突变表型推断	18253931	GOA
involved in regulation of protein localization to plasma membrane	IDA IDA: 通过直接分析推断	18570918	GOA
acts upstream of or within symbiont entry into host cell	IMP IMP: 通过突变表型推断	24550300	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of SNARE complex	IDA IDA: 通过直接分析推断	12130530	GOA
located in azurophil granule membrane	IDA IDA: 通过直接分析推断	16677249	GOA
located in cytoplasm	IDA IDA: 通过直接分析推断	18253931	GOA
located in cytosol	IDA IDA: 通过直接分析推断	22589474	GOA
located in late endosome membrane	IDA IDA: 通过直接分析推断	23217709	GOA
located in lysosomal membrane	IDA IDA: 通过直接分析推断	23217709	GOA
located in membrane	IDA IDA: 通过直接分析推断	16677249	GOA
located in mucin granule	IDA IDA: 通过直接分析推断	22144578	GOA
located in perinuclear region of cytoplasm	IDA IDA: 通过直接分析推断	18570918	GOA
located in plasma membrane	IDA IDA: 通过直接分析推断	18253931	GOA
located in recycling endosome	IDA IDA: 通过直接分析推断	18570918	GOA
located in secretory granule membrane	IDA IDA: 通过直接分析推断	16677249	GOA
located in vesicle	IDA IDA: 通过直接分析推断	18570918	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

VAMP8 蛋白结构

Synaptobrevin

0
100 a.a.

蛋白主名

其他名称

vesicle-associated membrane protein 8

vesicle-associated membrane protein 8 (endobrevin)

VAMP8 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
Intra	VAMP8	Q9BV40	STX17	Homo sapiens	P56962	Anti Tag CoIP	23217709
Intra	VAMP8	Q9BV40	STX7	Homo sapiens	O15400	Anti Tag CoIP	19557002
Intra	VAMP8	Q9BV40	STX7	Homo sapiens	O15400	Anti Tag CoIP	33422265
Intra	VAMP8	Q9BV40	SNAP29	Homo sapiens	O95721	Anti Tag CoIP	35271311
Intra	VAMP8	Q9BV40	SNAP29	Homo sapiens	O95721	Anti Tag CoIP	23217709

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Familial Hemophagocytic Lymphohistiocytosis 5

Fhl5	Hlh5
Hplh5	Lymphohistiocytosis, Hemophagocytic, Familial, Type 5

Hemophagocytic Lymphohistiocytosis, Familial, 4

Familial Hemophagocytic Lymphohistiocytosis 4	FHL4
Hplh4	Hlh4
Lymphohistiocytosis, Hemophagocytic, Familial, Type 4

Hermansky-Pudlak Syndrome 2

HPS2	Hermansky Pudlak Syndrome 2
Platelet Defects And Oculocutaneous Albinism	Albinism With Hemorrhagic Diathesis And Pigmented Reticuloendothelial
Delta Storage Pool Disease	Hermansky-Pudlak Syndrome, Type 2
Platelet Storage Pool Deficiency	Albinism With Hemorrhagic Diathesis And Pigmented Reticuloendothelial Cells

Ventricular Tachycardia, Catecholaminergic Polymorphic, 1, With Or Without Atrial Dysfunction And/Or Dilated Cardiomyopathy

Catecholaminergic Polymorphic Ventricular Tachycardia 1	Ventricular Tachycardia, Catecholaminergic Polymorphic, 1
CPVT1	Ventricular Tachycardia, Stress-Induced Polymorphic
Vtsip	Bidirectional Tachycardia
Stress-Induced Polymorphic Ventricular Tachycardia	Cvpt1
Double Tachycardia Induced By Catecholamines	Malignant Paroxysmal Ventricular Tachycardia
Multifocal Ventricular Premature Beats	Paroxysmal Ventricular Fibrillation
Syncopal Paroxysmal Tachycardia	Syncopal Tachyarythmia
Ventricular Tachycardia Catecholaminergic Polymorphic 1	Tachycardia, Ventricular, Catecholaminergic Polymorphic, Type 1
Multifocal Pvcs	Multifocal Premature Ventricular Beats
Paroxysmal Familial Ventricular Fibrillation	Catecholaminergic Polymorphic Ventricular Tachycardia Type 1

Vici Syndrome

Absent Corpus Callosum Cataract Immunodeficiency	VICIS
Immunodeficiency With Cleft Lip/Palate, Cataract, Hypopigmentation, And Absent Corpus Callosum	Dionisi Vici Sabetta Gambarara Syndrome
Immunodeficiency With Cleft Lip/Palate, Cataract, Hypopigmentation And Absent Corpus Callosum	Corpus Callosum Agenesis-Cataract-Immunodeficiency Syndrome
Dionisi-Vici-Sabetta-Gambarara Syndrome	Immunodeficiency With Cleft Lip/Palate Cataract Hypopigmentation And Absent Corpus Callosum

Hermansky-Pudlak Syndrome

Hps	Albinism With Hemorrhagic Diathesis And Pigmented Reticuloendothelial Cells
Hermanski-Pudlak Syndrome	Hermansky Pudlak Syndrome
Platelet Storage Pool Deficiency

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS15599	VAMP8 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Bos taurus	VAMP8	VGNC	VGNC:36760
Rattus norvegicus	VAMP8	RGD	RGD:620421
Mus musculus	VAMP8	MGD	MGI:1336882
Felis catus	VAMP8	VGNC	VGNC:66914
Canis familiaris	VAMP8	VGNC	VGNC:48227
Macaca mulatta	VAMP8	VGNC	VGNC:78754

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。	站点地图隐私声明
沪ICP备15051369号-4 上海工商沪公网安备31011502019417 沪(浦)应急管危经许[2021]201709(QFYS) 营业执照（三证合一）
Copyright © 2013-2024 MedChemExpress. All Rights Reserved.

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

VAMP8 - vesicle associated membrane protein 8 Gene

关于 VAMP8

功能概要

VAMP8 基因产物(1)

VAMP8 蛋白结构

VAMP8 蛋白互作信息

关联疾病

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

姓名
邮箱 *

Sorry, but the email address you supplied was invalid.

VAMP8 - vesicle associated membrane protein 8 Gene

关于 VAMP8

功能概要

VAMP8 基因产物(1)

VAMP8 蛋白结构

VAMP8 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z