2. Gene
  3. VPS11 - VPS11 core subunit of CORVET and HOPS complexes Gene

VPS11 - VPS11 core subunit of CORVET and HOPS complexes Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：CORVET 和 HOPS 复合体的 VPS11 核心亚基

种属: Homo sapiens

同用名: END1; PEP5; HLD12; RNF108; hVPS11; HLD12; DYT32

基因 ID: 55823 | 基因类型: protein coding

关于 VPS11

Cytogenetic location: 11q23.3 Genomic coordinates (GRCh38): 11:119,067,818-119,081,972 (from NCBI)

This gene has 8 transcripts (splice variants), 1 gene allele, 214 orthologues, 1 paralogue and is associated with 3 phenotypes. Ubiquitous expression in thyroid (RPKM 16.0), bone marrow (RPKM 14.4) and 25 other tissues.

功能概要

囊泡介导的蛋白质分选在将细胞内分子分离到不同的细胞器中起着重要作用。酵母的遗传研究已经确定了 40 多个液泡蛋白分选 (VPS) 基因参与囊泡向液泡的运输。该基因编码酵母 C 类 Vps11 蛋白的人类同系物。哺乳动物 C 类 Vps 蛋白主要与晚期内体/溶酶体相关，并且像它们的酵母对应物一样，可能介导内体/溶酶体途径中的囊泡运输步骤。可变剪接导致多个转录本变体。[RefSeq 提供，2014 年 2 月]

Vesicle mediated protein sorting plays an important role in segregation of intracellular molecules into distinct organelles. Genetic studies in yeast have identified more than 40 vacuolar protein sorting (VPS) genes involved in vesicle transport to vacuoles. This gene encodes the human homolog of yeast class C Vps11 protein. The mammalian class C Vps proteins are predominantly associated with late endosomes/lysosomes, and like their yeast counterparts, may mediate vesicle trafficking steps in the endosome/lysosome pathway. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]

VPS11 基因产物(6)

mRNA Protein Name
NM_001290185.2 NP_001277114.1 vacuolar protein sorting-associated protein 11 homolog isoform 2
NM_001378218.1 NP_001365147.1 vacuolar protein sorting-associated protein 11 homolog isoform 3
NM_001378219.1 NP_001365148.1 vacuolar protein sorting-associated protein 11 homolog isoform 4
NM_001378220.1 NP_001365149.1 vacuolar protein sorting-associated protein 11 homolog isoform 5
NM_001378221.1 NP_001365150.1 vacuolar protein sorting-associated protein 11 homolog isoform 6
NM_021729.6 NP_068375.3 vacuolar protein sorting-associated protein 11 homolog isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
11382755 GOA
enables protein domain specific binding IPI
IPI: 通过物理相互作用推断
21148287 GOA
enables syntaxin binding IDA
IDA: 通过直接分析推断
11382755 GOA
enables ubiquitin protein ligase activity IMP
IMP: 通过突变表型推断
31015428 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in endosomal vesicle fusion IMP
IMP: 通过突变表型推断
21148287 GOA
involved in endosome to lysosome transport IMP
IMP: 通过突变表型推断
25783203 GOA
involved in negative regulation of intracellular estrogen receptor signaling pathway IGI
IGI: 通过遗传相互作用推断
31015428 GOA
involved in positive regulation of early endosome to late endosome transport IMP
IMP: 通过突变表型推断
21148287 GOA
involved in positive regulation of protein catabolic process IMP
IMP: 通过突变表型推断
21148287 GOA
involved in protein ubiquitination IMP
IMP: 通过突变表型推断
31015428 GOA
involved in regulation of organelle assembly IMP
IMP: 通过突变表型推断
21148287 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of HOPS complex IDA
IDA: 通过直接分析推断
19109425 GOA
colocalizes with early endosome IDA
IDA: 通过直接分析推断
21148287 GOA
located in endocytic vesicle IDA
IDA: 通过直接分析推断
20682791 GOA
located in endosome IDA
IDA: 通过直接分析推断
20682791 GOA
colocalizes with late endosome IDA
IDA: 通过直接分析推断
21148287 GOA
located in late endosome IDA
IDA: 通过直接分析推断
11382755 GOA
colocalizes with lysosome IDA
IDA: 通过直接分析推断
21148287 GOA
located in lysosome IDA
IDA: 通过直接分析推断
11382755 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

VPS11 蛋白结构

Clathrin

Clathrin: Region in Clathrin and VPS (416 - 535)

zf-C3HC4_2

zf-C3HC4_2: Zinc finger, C3HC4 type (RING finger) (821 - 859)

VPS11_C

VPS11_C: Vacuolar protein sorting protein 11 C terminal (861 - 908)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 940 a.a.
蛋白主名 其他名称

vacuolar protein sorting-associated protein 11 homolog

RING finger protein 108

VPS11 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra VPS11 Q9H270 KRTAP10-8 Homo sapiens P60410
Y2H Prey Pooling
32296183
Intra VPS11 Q9H270 KRTAP10-8 Homo sapiens P60410
Y2H Array
32296183
Intra VPS11 Q9H270 KRTAP10-8 Homo sapiens P60410
Y2H Array
25416956
Intra VPS11 Q9H270 VPS39 Homo sapiens Q96JC1
Anti Tag CoIP
33422265
Intra VPS11 Q9H270 VPS39 Homo sapiens Q96JC1
Anti Tag CoIP
33961781
Intra VPS11 Q9H270 VPS39 Homo sapiens Q96JC1
Y2H
23901104
Intra VPS11 Q9H270 VPS18 Homo sapiens Q9P253
Anti Bait CoIP
11382755
Intra VPS11 Q9H270 VPS18 Homo sapiens Q9P253
Anti Tag CoIP
33961781
Intra VPS11 Q9H270 VPS18 Homo sapiens Q9P253
Y2H
23901104
Intra VPS11 Q9H270 VPS18 Homo sapiens Q9P253
Anti Tag CoIP
28514442
Intra VPS11 Q9H270 VPS18 Homo sapiens Q9P253
Anti Tag CoIP
26496610
Intra VPS11 Q9H270 VPS41 Homo sapiens P49754
Anti Tag CoIP
33422265
Intra VPS11 Q9H270 VPS41 Homo sapiens P49754
Anti Tag CoIP
33961781
Intra VPS11 Q9H270 BMI1 Homo sapiens P35226
Anti Tag CoIP
22493164
Intra VPS11 Q9H270 VPS33A Homo sapiens Q96AX1
Anti Tag CoIP
26496610
Intra VPS11 Q9H270 VPS33A Homo sapiens Q96AX1
Anti Tag CoIP
33961781
Intra VPS11 Q9H270 VPS16 Homo sapiens Q9H269
Anti Bait CoIP
11382755
Intra VPS11 Q9H270 VPS16 Homo sapiens Q9H269
Anti Tag CoIP
33961781
Intra VPS11 Q9H270 VPS16 Homo sapiens Q9H269
Anti Tag CoIP
26496610
Intra VPS11 Q9H270 TGFBRAP1 Homo sapiens Q8WUH2
Anti Tag CoIP
33961781
Intra VPS11 Q9H270 TGFBRAP1 Homo sapiens Q8WUH2
Anti Tag CoIP
28514442
Intra VPS11 Q9H270 TGFBRAP1 Homo sapiens Q8WUH2
Anti Tag CoIP
26496610
Intra VPS11 Q9H270 STX7 Homo sapiens O15400
Anti Tag CoIP
11382755
Intra VPS11 Q9H270 STX7 Homo sapiens O15400
Anti Bait CoIP
11382755
Intra VPS11 Q9H270 FGFR3 Homo sapiens P22607
Y2H Array
32814053
Intra VPS11 Q9H270 FGFR3 Homo sapiens P22607
Y2H Pooling
32814053
Intra VPS11 Q9H270 FGFR3 Homo sapiens P22607
Validated Y2H
32814053
Intra VPS11 Q9H270 HRAS Homo sapiens P01112
Validated Y2H
32814053
Intra VPS11 Q9H270 HRAS Homo sapiens P01112
Y2H Array
32814053
Intra VPS11 Q9H270 HRAS Homo sapiens P01112
Y2H Pooling
32814053
Intra VPS11 Q9H270 GSN Homo sapiens P06396
Y2H Array
32814053
Intra VPS11 Q9H270 GSN Homo sapiens P06396
Y2H Pooling
32814053
Intra VPS11 Q9H270 GSN Homo sapiens P06396
Validated Y2H
32814053
Intra VPS11 Q9H270 SPRED1 Homo sapiens Q7Z699
Y2H Array
32814053
Intra VPS11 Q9H270 SPRED1 Homo sapiens Q7Z699
Validated Y2H
32814053
Intra VPS11 Q9H270 SPRED1 Homo sapiens Q7Z699
Y2H Pooling
32814053
Intra VPS11 Q9H270 PECAM1 Homo sapiens P16284
Validated Y2H
32814053
Intra VPS11 Q9H270 PECAM1 Homo sapiens P16284
Y2H Array
32814053
Intra VPS11 Q9H270 PECAM1 Homo sapiens P16284
Y2H Pooling
32814053
Cross VPS11 Q9H270 Vps33a Rattus norvegicus Q63615
Anti Bait CoIP
11382755
Cross VPS11 Q9H270 Vps33a Rattus norvegicus Q63615
Anti Tag CoIP
11382755
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Leukodystrophy, Hypomyelinating, 12

Hypomyelinating Leukodystrophy 12

HLD12

Vps11-Related Autosomal Recessive Hypomyelinating Leukodystrophy

Vps11-Related Autosomal Recessive Hypomyelinating Leukoencephalopathy
Dystonia 32

DYT32
Dystonia

Dystonic Disease

Dystonic Disorder

Dystonia Disorders

Neuroleptic Dyskinesia
Chronic Apical Periodontitis

Apical Periodontitis Nos

Apex Periodontitis

Periapical Infection Nos
Leukodystrophy

Leukodystrophies
Visual Cortex Disease

Visual Cortex Dysfunction

Visual Cortex Disorder

Visual Cortical Disorder

Disease Of Visual Cortex
Visual Pathway Disease

Disorder Of Visual Pathways
Hypomyelinating Leukodystrophy

Hld

Leukodystrophy, Hypomyelinating
Microcephaly

Microencephaly

Microcephalus

Microcephalic

Nanocephaly

Congenital Microcephaly

Brain Hypoplasia

Brain Nondevelopment

Cephalic Hypoplasia

Undeveloped Cerebrum

Undeveloped Brain

Micrencephalon

Micrencephaly
Hermansky-Pudlak Syndrome

Hps

Albinism With Hemorrhagic Diathesis And Pigmented Reticuloendothelial Cells

Hermanski-Pudlak Syndrome

Hermansky Pudlak Syndrome

Platelet Storage Pool Deficiency
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS15671 VPS11 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus VPS11 RGD RGD:1308038
Mus musculus VPS11 MGD MGI:1918982
Macaca mulatta VPS11 VGNC VGNC:78965
Bos taurus VPS11 VGNC VGNC:36809
Canis familiaris VPS11 VGNC VGNC:48273
Felis catus VPS11 VGNC VGNC:66953
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