VPS39 - VPS39 subunit of HOPS complex Gene

中文名称：HOPS 复合体的 VPS39 亚基

种属: Homo sapiens

同用名: TLP; VAM6; hVam6p

基因 ID: 23339 | 基因类型: protein coding

关于 VPS39

Cytogenetic location: 15q15.1 Genomic coordinates (GRCh38): 15:42,158,701-42,208,304 (from NCBI)

This gene has 14 transcripts (splice variants), 210 orthologues and 1 paralogue. Ubiquitous expression in brain (RPKM 16.3), thyroid (RPKM 14.7) and 25 other tissues.

功能概要

该基因编码的蛋白质可促进晚期内体和溶酶体的聚集和融合。该蛋白质还可以作为衔接蛋白，通过将转化生长因子-β 受体复合物偶联到 Smad 通路来调节转化生长因子-β 反应。可变剪接导致多个转录本变体。[RefSeq 提供，2014 年 7 月]

This gene encodes a protein that may promote clustering and fusion of late endosomes and lysosomes. The protein may also act as an adaptor protein that modulates the transforming growth factor-beta response by coupling the transforming growth factor-beta receptor complex to the Smad pathway. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

VPS39 基因产物(2)

mRNA	Protein	Name
NM_001301138.3	NP_001288067.1	vam6/Vps39-like protein isoform a
NM_015289.5	NP_056104.2	vam6/Vps39-like protein isoform b

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	23901104	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in autophagosome-lysosome fusion	IDA IDA: 通过直接分析推断	33422265	GOA
involved in autophagy	IMP IMP: 通过突变表型推断	24554770	GOA
involved in endocytic recycling	IMP IMP: 通过突变表型推断	25266290	GOA
involved in endosomal vesicle fusion	IDA IDA: 通过直接分析推断	23167963	GOA
involved in endosome to lysosome transport	IMP IMP: 通过突变表型推断	25266290	GOA
involved in late endosome to lysosome transport	IDA IDA: 通过直接分析推断	23167963	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of HOPS complex	IDA IDA: 通过直接分析推断	19109425	GOA
located in late endosome	IDA IDA: 通过直接分析推断	33422265	GOA
located in late endosome membrane	IDA IDA: 通过直接分析推断	23167963	GOA
part of lysosomal HOPS complex	IDA IDA: 通过直接分析推断	33422265	GOA
located in lysosomal membrane	IDA IDA: 通过直接分析推断	23167963	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

VPS39 蛋白结构

CNH

Vps39_1

Vps39_2

0
200
400
600
800
886 a.a.

蛋白主名

其他名称

vam6/Vps39-like protein

TRAP1-like protein

VPS39 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
Intra	VPS39	Q96JC1	VPS18	Homo sapiens	Q9P253	Anti Tag CoIP	33422265
Intra	VPS39	Q96JC1	RAB7A	Homo sapiens	P51149	Anti Tag CoIP	33947832
Cross	VPS39	Q96JC1	ap3a_sars2	SARS-CoV-2	P0DTC3	Anti Tag CoIP	34706264
Cross	VPS39	Q96JC1	ap3a_sars2	SARS-CoV-2	P0DTC3	Anti Tag CoIP	33947832
Cross	VPS39	Q96JC1	ap3a_sars2	SARS-CoV-2	P0DTC3	Confocal	34706264
Cross	VPS39	Q96JC1	ap3a_sars2	SARS-CoV-2	P0DTC3	Pull Down	33947832
Intra	VPS39	Q96JC1	STX17	Homo sapiens	P56962	Anti Tag CoIP	24554770
Intra	VPS39	Q96JC1	STX17	Homo sapiens	P56962	Anti Tag CoIP	33422265
Intra	VPS39	Q96JC1	VPS11	Homo sapiens	Q9H270	Anti Tag CoIP	35271311

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Myopathy, Centronuclear, 1

Autosomal Dominant Centronuclear Myopathy	CNM1
Centronuclear Myopathy 1	Ad-Cnm
Myopathy, Centronuclear, Autosomal Dominant	Myotubular Myopathy, Autosomal Dominant
Centronuclear Myopathy, Autosomal, Modifier Of	Autosomal Dominant Myotubular Myopathy
Dnm2-Related Centronuclear Myopathy	Centronuclear Myopathy Autosomal Dominant
Myopathies, Structural, Congenital	Myopathy, Centronuclear, Type 1

Hermansky-Pudlak Syndrome 5

HPS5	Albinism With Hemorrhagic Diathesis And Pigmented Reticuloendothelial
Delta Storage Pool Disease	Hermansky-Pudlak Syndrome, Type 5
Platelet Storage Pool Deficiency	Albinism With Hemorrhagic Diathesis And Pigmented Reticuloendothelial Cells

Dystonia 12

DYT12	Rdp
Generalized Dystonia	Dystonia-12
Rapid-Onset Dystonia-Parkinsonism	Familial Dystonia
Dystonia Musculorum Deformans	Dystonic Disorders
Idiopathic Familial Dystonia	Dystonia-Parkinsonism, Rapid-Onset
Fragments Of Torsion Dystonia	Dyt-Atp1a3
Rapid-Onset Dystonia Parkinsonism	Rodp
Dystonia, Type 12	Dystonia 3, Torsion, X-Linked
Idiopathic Non-Familial Dystonia	Symptomatic Torsion Dystonia
Dystonia Disorders

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS15690	VPS39 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Canis familiaris	VPS39	VGNC	VGNC:48290
Bos taurus	VPS39	VGNC	VGNC:36822
Macaca mulatta	VPS39	VGNC	VGNC:79257
Mus musculus	VPS39	MGD	MGI:2443189
Felis catus	VPS39	VGNC	VGNC:66967
Rattus norvegicus	VPS39	RGD	RGD:1304858

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站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

VPS39 - VPS39 subunit of HOPS complex Gene

关于 VPS39

功能概要

VPS39 基因产物(2)

VPS39 蛋白结构

VPS39 蛋白互作信息

关联疾病

直系同源

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VPS39 - VPS39 subunit of HOPS complex Gene

关于 VPS39

功能概要

VPS39 基因产物(2)

VPS39 蛋白结构

VPS39 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

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B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z