POLD4 - DNA polymerase delta 4, accessory subunit Gene

中文名称：DNA 聚合酶 delta 4，辅助亚基

种属: Homo sapiens

同用名: p12; POLDS

关于 POLD4

功能概要

该基因编码 DNA 聚合酶 delta 的最小亚基。 DNA 聚合酶 delta 具有聚合酶和 3' 至 5' 核酸外切酶活性，在 DNA 复制和修复中起着关键作用。编码的蛋白质增强了 DNA 聚合酶 delta 的活性，并通过与 DNA 解旋酶 Bloom 综合征蛋白的相互作用在叉修复和稳定中发挥作用。已经观察到该基因编码多种亚型的可变剪接转录物变体。[RefSeq 提供，2012 年 3 月]

This gene encodes the smallest subunit of DNA Polymerase delta. DNA Polymerase delta possesses both polymerase and 3' to 5' exonuclease activity and plays a critical role in DNA replication and repair. The encoded protein enhances the activity of DNA Polymerase delta and plays a role in fork repair and stabilization through interactions with the DNA helicase Bloom syndrome protein. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Mar 2012]