POLD2 - DNA polymerase delta 2, accessory subunit Gene

中文名称：DNA 聚合酶 delta 2，辅助亚基

种属: Homo sapiens

关于 POLD2

功能概要

该基因编码 DNA 聚合酶 delta 的 50-kDa 催化亚基。 DNA 聚合酶 delta 具有聚合酶和 3' 至 5' 核酸外切酶活性，在 DNA 复制和修复中起着关键作用。所编码的蛋白质是持续合成辅助因子增殖细胞核抗原 (PCNA) 刺激 DNA 聚合酶 delta 活性所必需的。该基因的表达可能是卵巢癌的标志。已观察到该基因编码多种亚型的选择性剪接转录变体，该基因的假基因位于 5 号染色体的长臂上。[RefSeq 提供，2012 年 3 月]

This gene encodes the 50-kDa catalytic subunit of DNA Polymerase delta. DNA Polymerase delta possesses both polymerase and 3' to 5' exonuclease activity and plays a critical role in DNA replication and repair. The encoded protein is required for the stimulation of DNA Polymerase delta activity by the processivity cofactor proliferating cell nuclear antigen (PCNA). Expression of this gene may be a marker for ovarian carcinomas. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 5. [provided by RefSeq, Mar 2012]