2. Gene
  3. PTPRB - protein tyrosine phosphatase receptor type B Gene

PTPRB - protein tyrosine phosphatase receptor type B Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：B 型蛋白酪氨酸磷酸酶受体

种属: Homo sapiens

同用名: PTPB; HPTPB; VEPTP; HPTP-BETA; R-PTP-BETA

基因 ID: 5787 | 基因类型: protein coding

关于 PTPRB

Cytogenetic location: 12q15 Genomic coordinates (GRCh38): 12:70,515,870-70,637,429 (from NCBI)

This gene has 11 transcripts (splice variants), 266 orthologues, 35 paralogues and is associated with 89 phenotypes. Broad expression in lung (RPKM 16.0), spleen (RPKM 13.5) and 22 other tissues.

功能概要

该基因编码的蛋白质是蛋白酪氨酸磷酸酶 (PTP) 家族的成员。已知 PTP 是调节多种细胞过程的信号分子，包括细胞生长、分化、有丝分裂周期和致癌转化。该 PTP 含有一个胞外结构域、一个跨膜区和一个胞浆内催化结构域，属于受体型 PTP。该 PTP 的细胞外区域由多个纤连蛋白 type_III 重复序列组成，显示其与神经元受体和细胞粘附分子相互作用，例如接触素和生腱蛋白 C。还发现该蛋白质与钠通道相互作用，因此可能调节钠通过改变酪氨酸磷酸化状态来调节通道。这种蛋白质的相互作用伙伴的功能暗示了这种 PTP 在细胞粘附、轴突生长和神经元分化中的作用。已发现该基因编码不同亚型的替代转录变体。[RefSeq 提供，2011 年 5 月]

The protein encoded by this gene is a member of the protein tyrosine Phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and one intracytoplasmic catalytic domain, thus belongs to receptor type PTP. The extracellular region of this PTP is composed of multiple fibronectin type_III repeats, which was shown to interact with neuronal receptor and cell adhesion molecules, such as contactin and tenascin C. This protein was also found to interact with sodium channels, and thus may regulate sodium channels by altering tyrosine phosphorylation status. The functions of the interaction partners of this protein implicate the roles of this PTP in cell adhesion, neurite growth, and neuronal differentiation. Alternate transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2011]

PTPRB 基因产物(5)

mRNA Protein Name
NM_001109754.4 NP_001103224.1 receptor-type tyrosine-protein phosphatase beta isoform a
NM_001206971.3 NP_001193900.1 receptor-type tyrosine-protein phosphatase beta isoform c precursor
NM_001206972.3 NP_001193901.1 receptor-type tyrosine-protein phosphatase beta isoform d precursor
NM_001330204.2 NP_001317133.1 receptor-type tyrosine-protein phosphatase beta isoform e
NM_002837.6 NP_002828.3 receptor-type tyrosine-protein phosphatase beta isoform b precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables cadherin binding IPI
IPI: 通过物理相互作用推断
28926625 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
12840032 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in dephosphorylation IDA
IDA: 通过直接分析推断
19116766 GOA
involved in osteoblast differentiation IDA
IDA: 通过直接分析推断
22869525 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of receptor complex IDA
IDA: 通过直接分析推断
23382219 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

PTPRB 蛋白结构

fn3

fn3: Fibronectin type III domain (36 - 100)

fn3

fn3: Fibronectin type III domain (116 - 189)

fn3

fn3: Fibronectin type III domain (292 - 364)

fn3

fn3: Fibronectin type III domain (379 - 454)

fn3

fn3: Fibronectin type III domain (469 - 541)

fn3

fn3: Fibronectin type III domain (556 - 629)

fn3

fn3: Fibronectin type III domain (644 - 720)

fn3

fn3: Fibronectin type III domain (733 - 807)

fn3

fn3: Fibronectin type III domain (821 - 894)

fn3

fn3: Fibronectin type III domain (908 - 982)

fn3

fn3: Fibronectin type III domain (998 - 1072)

fn3

fn3: Fibronectin type III domain (1087 - 1160)

fn3

fn3: Fibronectin type III domain (1176 - 1248)

fn3

fn3: Fibronectin type III domain (1262 - 1342)

fn3

fn3: Fibronectin type III domain (1357 - 1431)

Y_phosphatase

Y_phosphatase: Protein-tyrosine phosphatase (1727 - 1960)

  • 0
  • 400
  • 800
  • 1200
  • 1600
  • 1997 a.a.
蛋白主名 其他名称

receptor-type tyrosine-protein phosphatase beta

VE-PTP

PTPRB 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra PTPRB P23467 TEK Homo sapiens Q02763
Phosphatase Assay
19167335
Intra PTPRB P23467 EGFR Homo sapiens P00533
Phosphatase Assay
19167335
Intra PTPRB P23467 ERBB2 Homo sapiens P04626
Phosphatase Assay
19167335
Intra PTPRB P23467 MAPK3 Homo sapiens P27361
Phosphatase Assay
19167335
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Generalized Epilepsy With Febrile Seizures Plus, Type 1

GEFSP1

GEFS+1

Generalized Epilepsy With Febrile Seizures Plus 1

Gefs+, Type 1

Generalised Epilepsy With Febrile Seizures Plus 1

Generalised Epilepsy With Febrile Seizures Plus Type 1

Generalized Epilepsy With Febrile Seizures Plus Type 1

Gefs+ Type 1

Epilepsy, Generalized, With Febrile Seizures Plus, Type 1
Skin Angiosarcoma

Angiosarcoma Of Skin

Hemangiosarcoma Of The Skin

Haemangiosarcoma Of Skin

Lymphangiosarcoma Of Skin

Cutaneous Angiosarcoma

Malignant Haemangioendothelioma Of Skin
Ovarian Angiosarcoma

Hemangiosarcoma Of Ovary
Diabetic Macular Edema
Liver Angiosarcoma

Angiosarcoma Of Liver

Angiosarcoma Of The Liver

Hemangiosarcoma Of The Liver

Primary Angiosarcoma Of Liver

Kupffer Cell Sarcoma Of Liver

Kupffer Cell Sarcoma Of Unspecified Site
Lymphangiosarcoma

Skin Lymphangiosarcoma

Stewart Treves Syndrome

Lymphangiosarcoma Of Stewart And Treves

Malignant Lymphangioendothelioma

Stewart-Treves Syndrome
Kuhnt-Junius Degeneration

Neovascular Age-Related Macular Degeneration

Exudative Senile Macular Degeneration Of Retina

Senile Macular Degeneration, Wet

Wet Senile Macular Retinal Degeneration

Exudative Age-Related Macular Degeneration

Exudative Macular Degeneration
Vascular Cancer

Blood Vessel Tumors

Malignant Vascular Neoplasm

Renal Vein Leiomyosarcoma

Vascular Neoplasms

Blood Vessel Neoplasm

Blood Vessel Tumor

Blood Vessel Tumour Disorder

Haemangiomatous Tumour

Leiomyosarcoma Of The Renal Vein

Malignant Great Vessel Tumor

Malignant Tumor Of Pulmonary Artery

Malignant Tumor Of Pulmonary Vein

Malignant Vascular Tumor

Neoplasm Of Great Vessel

Pulmonary Artery Malignant Neoplasm

Pulmonary Vein Malignant Neoplasm

Vascular Tissue Neoplasm

Vascular Tumors

Blood Vessel Cancer

Neoplasms, Vascular Tissue

Malignant Neoplasm Of Great Vessels
Generalized Epilepsy With Febrile Seizures Plus

Gefs+

Genetic Epilepsy With Febrile Seizures Plus

Generalized Epilepsy With Febrile Seizures-Plus

Genetic Epilepsy With Febrile Seizures-Plus

Epilepsy, Generalized, With Febrile Seizures Plus
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS11433 PTPRB Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus PTPRB MGD MGI:97809
Macaca mulatta PTPRB VGNC VGNC:76611
Bos taurus PTPRB VGNC VGNC:33545
Rattus norvegicus PTPRB RGD RGD:1305922
Felis catus PTPRB VGNC VGNC:69169
Canis familiaris PTPRB VGNC VGNC:45183
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z