SNX6 - sorting nexin 6 Gene

中文名称：排序 nexin 6

种属: Homo sapiens

同用名: TFAF2; MSTP010

关于 SNX6

功能概要

该基因编码分选连接蛋白家族的一个成员。该家族的成员包含一个 phox (PX) 结构域，它是一个磷酸肌醇结合结构域，并参与细胞内运输。这种蛋白质与瘦素受体的长亚型、受体丝氨酸-苏氨酸激酶的转化生长因子-β 家族以及血小板衍生生长因子、胰岛素和表皮生长因子的受体酪氨酸激酶相关。这种蛋白质可能通过分子的 PX 结构域和卷曲螺旋区域的相互作用与家族成员蛋白质形成寡聚复合物。在与前病毒整合位点 1 蛋白结合后，该蛋白从细胞质易位到细胞核。该基因产生两个转录本，编码两个不同的亚型。[RefSeq 提供，2008 年 7 月]

This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein associates with the long isoform of the Leptin receptor, the transforming growth factor-beta family of receptor serine-threonine kinases, and with Receptor Tyrosine Kinases for platelet-derived growth factor, Insulin, and epidermal growth factor. This protein may form oligomeric complexes with family member proteins through interactions of both the PX domain and the coiled coil regions of the molecules. Translocation of this protein from the cytoplasm to the nucleus occurs after binding to proviral integration site 1 protein. This gene results in two transcripts encoding two distinct isoforms. [provided by RefSeq, Jul 2008]