RAD9A - RAD9 checkpoint clamp component A Gene

中文名称：RAD9 检查点钳组件 A

种属: Homo sapiens

同用名: RAD9

基因 ID: 5883 | 基因类型: protein coding

关于 RAD9A

Cytogenetic location: 11q13.2 Genomic coordinates (GRCh38): 11:67,391,986-67,398,412 (from NCBI)

This gene has 11 transcripts (splice variants), 190 orthologues and 1 paralogue. Ubiquitous expression in spleen (RPKM 9.1), skin (RPKM 8.8) and 25 other tissues.

功能概要

该基因产物与 Schizosaccharomyces pombe rad9 高度相似，这是一种细胞周期停滞和 DNA 损伤修复所需的细胞周期检查点蛋白。这种蛋白质具有 3' 至 5' 核酸外切酶活性，这可能有助于其在检测和修复 DNA 损伤方面的作用。它与 RAD1 和 HUS1 形成检查点蛋白复合物。这种复合物被检查点蛋白 RAD17 募集到 DNA 损伤位点，这被认为对于触发检查点信号级联反应很重要。已发现该基因编码不同亚型的可变剪接转录物变体。[RefSeq 提供，2011 年 8 月]

This gene product is highly similar to Schizosaccharomyces pombe rad9, a cell cycle checkpoint protein required for cell cycle arrest and DNA damage repair. This protein possesses 3' to 5' exonuclease activity, which may contribute to its role in sensing and repairing DNA damage. It forms a checkpoint protein complex with RAD1 and HUS1. This complex is recruited by checkpoint protein RAD17 to the sites of DNA damage, which is thought to be important for triggering the checkpoint-signaling cascade. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]

RAD9A 基因产物(2)

mRNA	Protein	Name
NM_001243224.1	NP_001230153.1	cell cycle checkpoint control protein RAD9A isoform 2
NM_004584.3	NP_004575.1	cell cycle checkpoint control protein RAD9A isoform 1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables 3'-5' exonuclease activity	IDA IDA: 通过直接分析推断	10713044	GOA
enables SH3 domain binding	IPI IPI: 通过物理相互作用推断	11971963	GOA
enables enzyme binding	IPI IPI: 通过物理相互作用推断	15326225	GOA
enables histone deacetylase binding	IPI IPI: 通过物理相互作用推断	10846170	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	10359610	GOA
enables protein kinase binding	IPI IPI: 通过物理相互作用推断	12628935	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in DNA damage checkpoint signaling	IMP IMP: 通过突变表型推断	21659603	GOA
involved in DNA damage response	IDA IDA: 通过直接分析推断	9872989	GOA
involved in cellular response to ionizing radiation	IDA IDA: 通过直接分析推断	21659603	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of checkpoint clamp complex	IDA IDA: 通过直接分析推断	31776186	GOA
located in nucleus	IDA IDA: 通过直接分析推断	12628935	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

RAD9A 蛋白结构

Rad9

0
100
200
300
391 a.a.

蛋白主名

其他名称

cell cycle checkpoint control protein RAD9A

DNA repair exonuclease rad9 homolog A

RAD9A 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	RAD9A	Q99638	HUS1	Homo sapiens	O60921	Anti Tag CoIP	35271311
种属内	RAD9A	Q99638	HUS1	Homo sapiens	O60921	Anti Bait CoIP	10359610
种属内	RAD9A	Q99638	HUS1	Homo sapiens	O60921	Y2H Prey Pooling	32296183
种属内	RAD9A	Q99638	HUS1	Homo sapiens	O60921	Y2H Array	32296183
种属内	RAD9A	Q99638	HUS1	Homo sapiens	O60921	Y2H	10359610
种属内	RAD9A	Q99638	RAD1	Homo sapiens	O60671	Anti Tag CoIP	10359610
种属内	RAD9A	Q99638	RAD1	Homo sapiens	O60671	Anti Tag CoIP	35271311
种属内	RAD9A	Q99638	RAD17	Homo sapiens	O75943	Anti Tag CoIP	35271311
种属内	RAD9A	Q99638	RAD17	Homo sapiens	O75943	Anti Bait CoIP	20424596

种属间: 跨种属相互作用 种属内: 同种属相互作用

RAD9A 抗体

目录号	产品名	应用	反应物种
HY-P81342	Rad9 Antibody (YA1087)	WB, IP	Human, Mouse, Rat, Monkey

关联疾病

疾病名称

别名

Xeroderma Pigmentosum, Variant Type

Xeroderma Pigmentosum	XPV
Xeroderma Pigmentosum Variant Type	Xeroderma Pigmentosum With Normal Dna Repair Rates
Photosensitivity With Defective Dna Synthesis	Xp
De Sanctis-Cacchione Syndrome	Desanctis-Cacchione Syndrome
Xeroderma Pigmentosa	Xerodermic Idiocy
Xeroderma Pigmentosum Variant	Xp - [Xeroderma Pigmentosum]
Atrophoderma Pigmentosum

Seckel Syndrome

Microcephalic Primordial Dwarfism	Bird-Headed Dwarfism
Harper'S Syndrome	Virchow-Seckel Dwarfism
Nanocephalic Dwarfism	Sckl
Seckel-Type Dwarfism

Fanconi Anemia, Complementation Group A

Fanconi Anemia	Fanconi Pancytopenia
Fanconi Anemia Complementation Group A	FANCA
Fa	Fanconi Panmyelopathy
Fanconi'S Anemia	Fanconi Anaemia
Fanconi'S Anaemia	Fanconi Hypoplastic Anemia
Estren-Dameshek Variant Of Fanconi Anemia	Estren-Dameshek Variant Of Fanconi Pancytopenia
Fanconi Anemia Estren-Dameshek Variant	Fanconis Anemia

Hereditary Breast Ovarian Cancer Syndrome

Hereditary Breast And Ovarian Cancer Syndrome	Brca1- And Brca2-Associated Hereditary Breast And Ovarian Cancer
Breast And/Or Ovarian Cancer	Breast And Ovarian Cancer Syndrome
Hboc Syndrome	Hereditary Breast And Ovarian Cancer
Brca1- Brca2-Associated Hboc

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS11614	RAD9A Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Rattus norvegicus	RAD9A	RGD	RGD:2319938
Macaca mulatta	RAD9A	VGNC	VGNC:76648
Bos taurus	RAD9A	VGNC	VGNC:33689
Felis catus	RAD9A	VGNC	VGNC:69218
Mus musculus	RAD9A	MGD	MGI:1328356
Canis familiaris	RAD9A	VGNC	VGNC:45322

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站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

RAD9A - RAD9 checkpoint clamp component A Gene

关于 RAD9A

功能概要

RAD9A 基因产物(2)

RAD9A 蛋白结构

RAD9A 蛋白互作信息

RAD9A 抗体

关联疾病

直系同源

热门区域

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RAD9A - RAD9 checkpoint clamp component A Gene

关于 RAD9A

功能概要

RAD9A 基因产物(2)

RAD9A 蛋白结构

RAD9A 蛋白互作信息

RAD9A 抗体

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z