RAD1 - RAD1 checkpoint DNA exonuclease Gene

中文名称：RAD1 检查点 DNA 核酸外切酶

种属: Homo sapiens

同用名: REC1; HRAD1

关于 RAD1

功能概要

该基因编码异源三聚体细胞周期检查点复合物的一个成分，称为 9-1-1 复合物，该复合物被激活以停止细胞周期进程以响应 DNA 损伤或不完整的 DNA 复制。 9-1-1 复合物被 RAD17 募集到受影响的位点，在那里它可能吸引专门的 DNA 聚合酶和其他 DNA 修复效应器。已经描述了该基因的可变剪接转录物变体。[RefSeq 提供，2009 年 1 月]

This gene encodes a component of a heterotrimeric cell cycle checkpoint complex, known as the 9-1-1 complex, that is activated to stop cell cycle progression in response to DNA damage or incomplete DNA replication. The 9-1-1 complex is recruited by RAD17 to affected sites where it may attract specialized DNA polymerases and Other DNA repair effectors. Alternatively spliced transcript variants of this gene have been described. [provided by RefSeq, Jan 2009]