HUS1 - HUS1 checkpoint clamp component Gene

中文名称：HUS1 检查点钳组件

种属: Homo sapiens

同用名: hHUS1

关于 HUS1

功能概要

由该基因编码的蛋白质是进化上保守的、基因毒素激活的检查点复合物的组成部分，该检查点复合物参与响应 DNA 损伤的细胞周期停滞。该蛋白与检查点蛋白 RAD9 和 RAD1 形成异源三聚体复合物。为了应对 DNA 损伤，三聚体复合物与另一种蛋白质复合物相互作用，该蛋白质复合物由检查点蛋白 RAD17 和复制因子 C (RFC) 的四个小亚基组成，后者将结合的复合物加载到染色质上。 DNA 损伤诱导的染色质结合已被证明取决于检查点激酶 ATM 的激活，并且被认为是早期检查点信号事件。可变剪接导致多个转录本变体。[RefSeq 提供，2011 年 2 月]

The protein encoded by this gene is a component of an evolutionarily conserved, genotoxin-activated checkpoint complex that is involved in the cell cycle arrest in response to DNA damage. This protein forms a heterotrimeric complex with checkpoint proteins RAD9 and RAD1. In response to DNA damage, the trimeric complex interacts with another protein complex consisting of checkpoint protein RAD17 and four small subunits of the replication factor C (RFC), which loads the combined complex onto the chromatin. The DNA damage induced chromatin binding has been shown to depend on the activation of the checkpoint kinase ATM, and is thought to be an early checkpoint signaling event. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2011]