2. Gene
  3. RARG - retinoic acid receptor gamma Gene

RARG - retinoic acid receptor gamma Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：视黄酸受体γ

种属: Homo sapiens

同用名: RARC; NR1B3; RARgamma

基因 ID: 5916 | 基因类型: protein coding

关于 RARG

Cytogenetic location: 12q13.13 Genomic coordinates (GRCh38): 12:53,210,569-53,232,209 (from NCBI)

This gene has 18 transcripts (splice variants), 449 orthologues and 18 paralogues. Broad expression in skin (RPKM 47.1), esophagus (RPKM 32.0) and 18 other tissues.

功能概要

该基因编码属于核激素受体家族的视黄酸受体。视黄酸受体 (RAR) 充当配体依赖性转录调节因子。当与配体结合时，RAR 通过以异二聚体形式结合靶基因启动子区域中的视黄酸反应元件 (RARE) 来激活转录。在未结合的形式下，RAR 会抑制其靶基因的转录。 RARs 参与各种生物过程，包括肢芽发育、骨骼生长和基质稳态。已发现该基因编码不同亚型的可变剪接转录物变体。[RefSeq 提供，2011 年 8 月]

This gene encodes a retinoic acid receptor that belongs to the nuclear hormone receptor family. Retinoic acid receptors (RARs) act as ligand-dependent transcriptional regulators. When bound to ligands, RARs activate transcription by binding as heterodimers to the retinoic acid response elements (RARE) found in the promoter regions of the target genes. In their unbound form, RARs repress transcription of their target genes. RARs are involved in various biological processes, including limb bud development, skeletal growth, and matrix homeostasis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]

RARG 基因产物(5)

mRNA Protein Name
NM_000966.6 NP_000957.1 retinoic acid receptor gamma isoform 1
NM_001042728.3 NP_001036193.1 retinoic acid receptor gamma isoform 2
NM_001243730.2 NP_001230659.1 retinoic acid receptor gamma isoform 4
NM_001243731.2 NP_001230660.1 retinoic acid receptor gamma isoform 5
NM_001243732.2 NP_001230661.1 retinoic acid receptor gamma isoform 3
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
10428834 GOA
enables sequence-specific double-stranded DNA binding IDA
IDA: 通过直接分析推断
28473536 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in response to retinoic acid IDA
IDA: 通过直接分析推断
17943189 GOA
involved in retinoic acid receptor signaling pathway IDA
IDA: 通过直接分析推断
17943189 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in chromatin IDA
IDA: 通过直接分析推断
21131358 GOA
located in nucleus IDA
IDA: 通过直接分析推断
18845237 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

RARG 蛋白结构

zf-C4

zf-C4: Zinc finger, C4 type (two domains) (89 - 157)

Hormone_recep

Hormone_recep: Ligand-binding domain of nuclear hormone receptor (227 - 395)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 454 a.a.
蛋白主名 其他名称

retinoic acid receptor gamma

RAR-gamma

RARG 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra RARG P13631 SORBS3 Homo sapiens O60504-2
Anti Bait CoIP
15734736
Intra RARG P13631 MYF5 Homo sapiens P13349
Y2H Array
32296183
Intra RARG P13631 MYF5 Homo sapiens P13349
Y2H Prey Pooling
32296183
Intra RARG P13631 BBS4 Homo sapiens Q96RK4
Y2H Prey Pooling
32296183
Intra RARG P13631 BBS4 Homo sapiens Q96RK4
Validated Y2H
32296183
Intra RARG P13631 BBS4 Homo sapiens Q96RK4
Y2H Array
32296183
Intra RARG P13631 PRKAR1B Homo sapiens P31321
Y2H Array
32296183
Intra RARG P13631 PRKAR1B Homo sapiens P31321
Validated Y2H
32296183
Intra RARG P13631 PRKAR1B Homo sapiens P31321
Y2H Prey Pooling
32296183
Intra RARG P13631 RXRG Homo sapiens P48443
Validated Y2H
32296183
Intra RARG P13631 RXRB Homo sapiens P28702
Anti Tag CoIP
33961781
Intra RARG P13631 RXRB Homo sapiens P28702
Anti Tag CoIP
28514442
Intra RARG P13631 RXRB Homo sapiens P28702
Validated Y2H
32296183
Intra RARG P13631 RXRB Homo sapiens P28702
Y2H Prey Pooling
32296183
Intra RARG P13631 RXRB Homo sapiens P28702
Y2H Array
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Embryonal Carcinoma

Embryonal Neoplasm

Embryonal Cancer

Primary Extragonadal Embryonal Carcinoma

Embryo Neoplasm

Carcinoma Embryonal

Cancer Embryonal

Carcinoma, Embryonal

Extragonadal Embryonal Carcinoma

Cancer, Embryonal
Acute Promyelocytic Leukemia

Leukemia, Acute Promyelocytic

Acute Myeloblastic Leukemia Type 3

Aml M3

APL

Leukemia, Acute Promyelocytic, Somatic

Aml With T(15

17)(Q22

Q12)

(Pml/Raralpha) And Variants

Apml

Acute Myeloblastic Leukemia 3

Acute Myeloid Leukemia With T(15

17)(Q22

Q12)

(Pml/Raralpha) And Variants

Acute Myeloblastic Leukaemia Type 3

Acute Myeloid Leukaemia M3

Acute Myeloid Leukemia M3

Acute Promyelocytic Leukaemia

M3 Anll

Myeloid Leukemia, Acute, M3

Leukemia Promyelocytic Acute

Leukemia, Promyelocytic, Acute

Leukemia, Acute, Promyelocytic
Fibrodysplasia Ossificans Progressiva

Myositis Ossificans Progressiva

Progressive Myositis Ossificans

FOP

Progressive Ossifying Myositis

Myositis Ossificans

Stone Man Syndrome

Man Of Stone

Myositis Ossificans Progressive

Diffuse Progressive Ossifying Polymyositis

Fibrodysplasia Ossificans Congenita

Myositis Ossificans Progressiva, Site Unspecified

Münchmeyer Disease

Fop - [Fibrodysplasia Ossificans Progressiva]

Progressive Myositis Ossificans Calcification
Pancreatic Cancer

Pancreatic Carcinoma

Carcinoma Of Pancreas

Familial Pancreatic Carcinoma

Pancreatic Neoplasm

Pancreatic Carcinoma, Familial

Malignant Neoplasm Of Pancreas

Pancreatic Acinar Carcinoma

Pancreatic Tumor

Familial Pancreatic Cancer

Neoplasm Of The Pancreas

Cancer Of The Pancreas

Pancreatic Carcinoma, Somatic

Pancreatic Cancer, Somatic

Ca Body Of Pancreas

Ca Head Of Pancreas

Ca Tail Of Pancreas

Malignant Neoplasm Of Body Of Pancreas

Malignant Neoplasm Of Head Of Pancreas

Malignant Neoplasm Of Tail Of Pancreas

Pancreas Neoplasm

Exocrine Cancer

Exocrine Pancreas Carcinoma

Hereditary Pancreatic Cancer

Hereditary Pancreatic Carcinoma

PNCA

Pancreatic Cancer, Susceptibility To

Carcinoma Of Head Of Pancreas

Pancreatic Neoplasms

Pancreatic Tumors

Cancer, Pancreatic

Cancer Of Pancreas

Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-155108B OATD-02 hydrochloride Inhibitor 99.88% 否
HY-155108 OATD-02 Inhibitor / 否
HY-RS11673 RARG Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus RARG VGNC VGNC:33730
Felis catus RARG VGNC VGNC:69242
Canis familiaris RARG VGNC VGNC:45353
Macaca mulatta RARG VGNC VGNC:76664
Rattus norvegicus RARG RGD RGD:1583230
Mus musculus RARG MGD MGI:97858
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