RARG - retinoic acid receptor gamma Gene

中文名称：视黄酸受体γ

种属: Homo sapiens

同用名: RARC; NR1B3; RARgamma

基因 ID: 5916 | 基因类型: protein coding

关于 RARG

Cytogenetic location: 12q13.13 Genomic coordinates (GRCh38): 12:53,210,569-53,232,209 (from NCBI)

This gene has 18 transcripts (splice variants), 449 orthologues and 18 paralogues. Broad expression in skin (RPKM 47.1), esophagus (RPKM 32.0) and 18 other tissues.

功能概要

该基因编码属于核激素受体家族的视黄酸受体。视黄酸受体 (RAR) 充当配体依赖性转录调节因子。当与配体结合时，RAR 通过以异二聚体形式结合靶基因启动子区域中的视黄酸反应元件 (RARE) 来激活转录。在未结合的形式下，RAR 会抑制其靶基因的转录。 RARs 参与各种生物过程，包括肢芽发育、骨骼生长和基质稳态。已发现该基因编码不同亚型的可变剪接转录物变体。[RefSeq 提供，2011 年 8 月]

This gene encodes a retinoic acid receptor that belongs to the nuclear hormone receptor family. Retinoic acid receptors (RARs) act as ligand-dependent transcriptional regulators. When bound to ligands, RARs activate transcription by binding as heterodimers to the retinoic acid response elements (RARE) found in the promoter regions of the target genes. In their unbound form, RARs repress transcription of their target genes. RARs are involved in various biological processes, including limb bud development, skeletal growth, and matrix homeostasis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]

RARG 基因产物(5)

mRNA	Protein	Name
NM_000966.6	NP_000957.1	retinoic acid receptor gamma isoform 1
NM_001042728.3	NP_001036193.1	retinoic acid receptor gamma isoform 2
NM_001243730.2	NP_001230659.1	retinoic acid receptor gamma isoform 4
NM_001243731.2	NP_001230660.1	retinoic acid receptor gamma isoform 5
NM_001243732.2	NP_001230661.1	retinoic acid receptor gamma isoform 3

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	10428834	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: 通过直接分析推断	28473536	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in response to retinoic acid	IDA IDA: 通过直接分析推断	17943189	GOA
involved in retinoic acid receptor signaling pathway	IDA IDA: 通过直接分析推断	17943189	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in chromatin	IDA IDA: 通过直接分析推断	21131358	GOA
located in nucleus	IDA IDA: 通过直接分析推断	18845237	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

RARG 蛋白结构

zf-C4

Hormone_recep

0
100
200
300
400
454 a.a.

蛋白主名

其他名称

retinoic acid receptor gamma

RAR-gamma

RARG 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	RARG	P13631	SORBS3	Homo sapiens	O60504-2	Anti Bait CoIP	15734736
种属内	RARG	P13631	MYF5	Homo sapiens	P13349	Y2H Array	32296183
种属内	RARG	P13631	MYF5	Homo sapiens	P13349	Y2H Prey Pooling	32296183
种属内	RARG	P13631	BBS4	Homo sapiens	Q96RK4	Y2H Prey Pooling	32296183
种属内	RARG	P13631	BBS4	Homo sapiens	Q96RK4	Validated Y2H	32296183
种属内	RARG	P13631	BBS4	Homo sapiens	Q96RK4	Y2H Array	32296183
种属内	RARG	P13631	PRKAR1B	Homo sapiens	P31321	Y2H Array	32296183
种属内	RARG	P13631	PRKAR1B	Homo sapiens	P31321	Validated Y2H	32296183
种属内	RARG	P13631	PRKAR1B	Homo sapiens	P31321	Y2H Prey Pooling	32296183
种属内	RARG	P13631	RXRG	Homo sapiens	P48443	Validated Y2H	32296183
种属内	RARG	P13631	RXRB	Homo sapiens	P28702	Anti Tag CoIP	33961781
种属内	RARG	P13631	RXRB	Homo sapiens	P28702	Anti Tag CoIP	28514442
种属内	RARG	P13631	RXRB	Homo sapiens	P28702	Validated Y2H	32296183
种属内	RARG	P13631	RXRB	Homo sapiens	P28702	Y2H Prey Pooling	32296183
种属内	RARG	P13631	RXRB	Homo sapiens	P28702	Y2H Array	32296183

种属间: 跨种属相互作用 种属内: 同种属相互作用

RARG 抗体

目录号	产品名	应用	反应物种
HY-P82115	Retinoic Acid Receptor gamma Antibody (YA1860)	WB, ICC/IF	Human, Rat

关联疾病

疾病名称

别名

Embryonal Carcinoma

Embryonal Neoplasm	Embryonal Cancer
Primary Extragonadal Embryonal Carcinoma	Embryo Neoplasm
Carcinoma Embryonal	Cancer Embryonal
Carcinoma, Embryonal	Extragonadal Embryonal Carcinoma
Cancer, Embryonal

Acute Promyelocytic Leukemia

Leukemia, Acute Promyelocytic	Acute Myeloblastic Leukemia Type 3
Aml M3	APL
Leukemia, Acute Promyelocytic, Somatic	Aml With T(15
17)(Q22	Q12)
(Pml/Raralpha) And Variants	Apml
Acute Myeloblastic Leukemia 3	Acute Myeloid Leukemia With T(15
17)(Q22	Q12)
(Pml/Raralpha) And Variants	Acute Myeloblastic Leukaemia Type 3
Acute Myeloid Leukaemia M3	Acute Myeloid Leukemia M3
Acute Promyelocytic Leukaemia	M3 Anll
Myeloid Leukemia, Acute, M3	Leukemia Promyelocytic Acute
Leukemia, Promyelocytic, Acute	Leukemia, Acute, Promyelocytic

Fibrodysplasia Ossificans Progressiva

Myositis Ossificans Progressiva	Progressive Myositis Ossificans
FOP	Progressive Ossifying Myositis
Myositis Ossificans	Stone Man Syndrome
Man Of Stone	Myositis Ossificans Progressive
Diffuse Progressive Ossifying Polymyositis	Fibrodysplasia Ossificans Congenita
Myositis Ossificans Progressiva, Site Unspecified	Münchmeyer Disease
Fop - [Fibrodysplasia Ossificans Progressiva]	Progressive Myositis Ossificans Calcification

Pancreatic Cancer

Pancreatic Carcinoma	Carcinoma Of Pancreas
Familial Pancreatic Carcinoma	Pancreatic Neoplasm
Pancreatic Carcinoma, Familial	Malignant Neoplasm Of Pancreas
Pancreatic Acinar Carcinoma	Pancreatic Tumor
Familial Pancreatic Cancer	Neoplasm Of The Pancreas
Cancer Of The Pancreas	Pancreatic Carcinoma, Somatic
Pancreatic Cancer, Somatic	Ca Body Of Pancreas
Ca Head Of Pancreas	Ca Tail Of Pancreas
Malignant Neoplasm Of Body Of Pancreas	Malignant Neoplasm Of Head Of Pancreas
Malignant Neoplasm Of Tail Of Pancreas	Pancreas Neoplasm
Exocrine Cancer	Exocrine Pancreas Carcinoma
Hereditary Pancreatic Cancer	Hereditary Pancreatic Carcinoma
PNCA	Pancreatic Cancer, Susceptibility To
Carcinoma Of Head Of Pancreas	Pancreatic Neoplasms
Pancreatic Tumors	Cancer, Pancreatic
Cancer Of Pancreas	Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-155108B	OATD-02 hydrochloride	Inhibitor	99.88%	否
HY-155108	OATD-02	Inhibitor	/	否
HY-RS11673	RARG Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Bos taurus	RARG	VGNC	VGNC:33730
Felis catus	RARG	VGNC	VGNC:69242
Canis familiaris	RARG	VGNC	VGNC:45353
Macaca mulatta	RARG	VGNC	VGNC:76664
Rattus norvegicus	RARG	RGD	RGD:1583230
Mus musculus	RARG	MGD	MGI:97858

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站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

RARG - retinoic acid receptor gamma Gene

关于 RARG

功能概要

RARG 基因产物(5)

RARG 蛋白结构

RARG 蛋白互作信息

RARG 抗体

关联疾病

直系同源

热门区域

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RARG - retinoic acid receptor gamma Gene

关于 RARG

功能概要

RARG 基因产物(5)

RARG 蛋白结构

RARG 蛋白互作信息

RARG 抗体

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z