2. Gene
  3. RXRB - retinoid X receptor beta Gene

RXRB - retinoid X receptor beta Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：维甲酸 X 受体 β

种属: Homo sapiens

同用名: NR2B2; DAUDI6; RCoR-1; RXRbeta; H-2RIIBP; RXR-beta

基因 ID: 6257 | 基因类型: protein coding

关于 RXRB

Cytogenetic location: 6p21.32 Genomic coordinates (GRCh38): 6:33,193,588-33,200,853 (from NCBI)

This gene has 5 transcripts (splice variants), 1 gene allele, 215 orthologues and 11 paralogues. Ubiquitous expression in thyroid (RPKM 13.3), spleen (RPKM 12.9) and 25 other tissues.

功能概要

该基因编码视黄酸 X 受体 (RXR) 核受体家族的成员，这些核受体参与介导视黄酸 (RA) 的作用。编码的蛋白质与视黄酸、甲状腺激素和维生素 D 受体形成同源二聚体，从而增加它们各自反应元件的 DNA 结合和转录功能。该基因位于 6 号染色体上的主要组织相容性复合体 (MHC) II 类区域中。已经观察到该基因编码多种亚型的可变剪接转录物变体。[RefSeq 提供，2012 年 7 月]

This gene encodes a member of the retinoid X receptor (RXR) family of nuclear receptors which are involved in mediating the effects of retinoic acid (RA). The encoded protein forms homodimers with the retinoic acid, thyroid hormone, and vitamin D receptors, increasing both DNA binding and transcriptional function on their respective response elements. This gene lies within the major histocompatibility complex (MHC) class II region on chromosome 6. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]

RXRB 基因产物(3)

mRNA Protein Name
NM_001270401.2 NP_001257330.1 retinoic acid receptor RXR-beta isoform 1
NM_001291989.2 NP_001278918.1 retinoic acid receptor RXR-beta isoform 3
NM_021976.5 NP_068811.1 retinoic acid receptor RXR-beta isoform 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
IDA: 通过直接分析推断
12767074 GOA
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
IDA: 通过直接分析推断
12767074 GOA
enables nuclear receptor activity IDA
IDA: 通过直接分析推断
1662118 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
16189514 GOA
enables sequence-specific double-stranded DNA binding IDA
IDA: 通过直接分析推断
28473536 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in positive regulation of DNA-templated transcription IDA
IDA: 通过直接分析推断
1662118 GOA
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
12767074 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of RNA polymerase II transcription regulator complex IPI
IPI: 通过物理相互作用推断
25416956 GOA
located in nucleus IDA
IDA: 通过直接分析推断
7990953 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

RXRB 蛋白结构

zf-C4

zf-C4: Zinc finger, C4 type (two domains) (204 - 272)

Hormone_recep

Hormone_recep: Ligand-binding domain of nuclear hormone receptor (336 - 513)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 533 a.a.
蛋白主名 其他名称

retinoic acid receptor RXR-beta

MHC class I promoter binding protein

RXRB 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra RXRB P28702 NR1H2 Homo sapiens F1D8P7
Y2H Prey Pooling
32296183
Intra RXRB P28702 NR1H2 Homo sapiens F1D8P7
Y2H Array
32296183
Intra RXRB P28702 RARA Homo sapiens P10276-2
Y2H Prey Pooling
26871637
Intra RXRB P28702 RARA Homo sapiens P10276-2
Y2H Array
26871637
Intra RXRB P28702 RARA Homo sapiens P10276-2
Validated Y2H
26871637
Intra RXRB P28702 CACNA1B Homo sapiens Q00975
Display Tech
20195357
Intra RXRB P28702 NR1H3 Homo sapiens Q13133-3
Y2H Array
26871637
Intra RXRB P28702 NR1H3 Homo sapiens Q13133-3
Validated Y2H
32296183
Intra RXRB P28702 NR1H3 Homo sapiens Q13133-3
Y2H Prey Pooling
26871637
Intra RXRB P28702 NR1H3 Homo sapiens Q13133-3
Validated Y2H
26871637
Intra RXRB P28702 NR1H4 Homo sapiens Q96RI1-1
Y2H Prey Pooling
26871637
Intra RXRB P28702 NR1H4 Homo sapiens Q96RI1-1
Validated Y2H
26871637
Intra RXRB P28702 NR1H4 Homo sapiens Q96RI1-1
Y2H Array
26871637
Intra RXRB P28702 NR1H4 Homo sapiens Q96RI1-1
Y2H Prey Pooling
32296183
Intra RXRB P28702 NR1H4 Homo sapiens Q96RI1-1
Validated Y2H
32296183
Intra RXRB P28702 NR1H4 Homo sapiens Q96RI1-1
Y2H Array
32296183
Intra RXRB P28702 RARG Homo sapiens P13631
Y2H Array
32296183
Intra RXRB P28702 RARG Homo sapiens P13631
Y2H Prey Pooling
32296183
Intra RXRB P28702 SPOPL Homo sapiens Q6IQ16
Validated Y2H
32296183
Intra RXRB P28702 SPOPL Homo sapiens Q6IQ16
Y2H Array
32296183
Intra RXRB P28702 SPOPL Homo sapiens Q6IQ16
Y2H Prey Pooling
32296183
Intra RXRB P28702 RARA Homo sapiens P10276
Validated Y2H
26871637
Intra RXRB P28702 RARA Homo sapiens P10276
Y2H Array
31515488
Intra RXRB P28702 RARA Homo sapiens P10276
Y2H Array
26871637
Intra RXRB P28702 RARA Homo sapiens P10276
Y2H Array
29892012
Intra RXRB P28702 RARA Homo sapiens P10276
Y2H Prey Pooling
26871637
Intra RXRB P28702 RARA Homo sapiens P10276
Y2H
21988832
Intra RXRB P28702 NR3C1 Homo sapiens P04150
Pull Down
20211142
Intra RXRB P28702 MYG1 Homo sapiens Q9HB07
Validated Y2H
32296183
Intra RXRB P28702 MYG1 Homo sapiens Q9HB07
Y2H Array
32296183
Intra RXRB P28702 MYG1 Homo sapiens Q9HB07
Y2H Prey Pooling
32296183
Intra RXRB P28702 NR1H3 Homo sapiens Q13133
Y2H Array
25416956
Intra RXRB P28702 PPARG Homo sapiens P37231
Pull Down
20211142
Intra RXRB P28702 PICK1 Homo sapiens Q9NRD5
Validated Y2H
32296183
Intra RXRB P28702 PICK1 Homo sapiens Q9NRD5
Y2H Prey Pooling
32296183
Intra RXRB P28702 PICK1 Homo sapiens Q9NRD5
Y2H Array
32296183
Intra RXRB P28702 RARB Homo sapiens P10826-2
Validated Y2H
26871637
Intra RXRB P28702 RARB Homo sapiens P10826-2
Y2H Array
26871637
Intra RXRB P28702 RARB Homo sapiens P10826-2
MAPPIT
25416956
Intra RXRB P28702 RARB Homo sapiens P10826-2
Y2H Array
25416956
Intra RXRB P28702 RARB Homo sapiens P10826-2
Y2H Prey Pooling
26871637
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Granulomatosis With Polyangiitis

GPA

Wegener Granulomatosis

Wegener Granulomatosis, Formerly

Midline Granulomatosis

Wg, Formerly

Necrotizing Respiratory Granulomatosis

Wg

Wegeners Granulomatosis

Pauci-Immune Glomerulonephritis Associated With Granulomatosis With Polyangiitis
Vasculitis

Angiitis

Autoimmune Vasculitis

Systemic Vasculitis

Vasculitis, Autoimmune
Otospondylomegaepiphyseal Dysplasia, Autosomal Dominant

Weissenbacher-Zweymuller Syndrome

Wzs

Pierre Robin Syndrome With Fetal Chondrodysplasia

OSMEDA

Weissenbacher-Zweymüller Syndrome

Heterozygous Osmed

Stickler Syndrome, Type 3

Osmed, Heterozygous

Pierre Robin Syndrome With Fetal Chondrodysplasia Stickler Syndrome, Nonocular Type, Formerly

Stickler Syndrome, Type Iii, Formerly

Stl3, Formerly

Piere-Robin Syndrome

Pierre Robin Malformation

Heterozygous Otospondylomegaepiphyseal Dysplasia

Autosomal Dominant Otospondylomegaepiphyseal Dysplasia

Ad Osmed

Stickler Syndrome Type 3

Stickler Syndrome, Non-Ocular Type

Stickler-Like Syndrome

Stickler Syndrome 3

Stickler Syndrome Non-Ocular Type

Stickler Syndrome Type Iii

Stl3

Weissenbacher-Zweymueller Syndrome

Stickler Syndrome, Type Iii

Pierre Robin Syndrome

Dysplasia, Otospondylomegaepiphyseal, Autosomal Dominant
Lung Cancer

Lung Carcinoma

Non-Small Cell Lung Carcinoma

Lung Cancer, Susceptibility To

Lung Cancer, Protection Against

Adenocarcinoma Of Lung, Somatic

Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer

Lung Neoplasm

Carcinoma Of Lung

Lung Non-Small Cell Carcinoma

Non-Small Cell Lung Cancer

Nsclc

Lung Neoplasms

Malignant Neoplasm Of Lung

Alveolar Cell Carcinoma

Nonsmall Cell Lung Cancer, Somatic

Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer, Susceptibility To

Lung Cancer, Somatic

Lung Cancer, Resistance To

Cancer Of Lung

Cancer Of Bronchus

Cancer Of The Lung

Lung Malignancies

Lung Malignant Tumors

Malignant Lung Tumor

Malignant Tumor Of Lung

Pulmonary Cancer

Pulmonary Carcinoma

Pulmonary Neoplasms

Respiratory Carcinoma

LNCR

Adenocarcinoma Of Lung

Neoplasm Of Lung

Cancer Lung

Carcinoma Non-Small Cell Lung

Carcinoma, Non-Small-Cell Lung

Lung Cancers

Lung Carcinomas

Cancer, Lung

Cancer, Lung, Non-Small Cell

Primary Malignant Neoplasm Of Lung

Bronchioloalveolar Adenocarcinoma
Endometrial Cancer

Endometrial Carcinoma

Endometrial Neoplasm

Malignant Neoplasm Of Endometrium

Endometrioid Carcinoma

Endometrial Neoplasms

Carcinoma, Endometrioid

Endometrial Cancer, Familial

Endometrial Carcinoma, Somatic

Endometrial Cancer, Susceptibility To

Endometrial Ca

Malignant Endometrial Neoplasm

Neoplasm Of Endometrium

Primary Malignant Neoplasm Of Endometrium

Tumor Of Endometrium

Carcinoma Of The Endometrium

Endometrioid Carcinoma Of Female Reproductive System

ENDMC

Carcinoma Endometrioid

Endometrial Cancers

Cancer, Endometrial

Uterine Corpus Cancer
Alcohol Dependence

Alcoholism

Alcohol Dependence, Susceptibility To

Alcohol Dependence, Protection Against

Aerodigestive Tract Cancer, Squamous Cell, Alcohol-Related, Protection Against

Alcoholism, Susceptibility To

Alcoholic Intoxication, Chronic

Pharyngeal Neoplasms

Chronic Alcoholism

Dipsomania

Alcohol Addiction

Ethanol Dependence

Chronic Ethanolism

Chronic Alcoholic Disease Nos

Alcoholic Disease Nos

Alcoholic
Schizophrenia

SCZD

Schizophrenia With Or Without An Affective Disorder

Schizophrenia 12

Schizophrenia, Susceptibility To

Schizophrenia-1

Dementia Praecox

Schizophrenia 1
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (2)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS12362 RXRB Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-160212 JP3000 Agonist / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris RXRB VGNC VGNC:45818
Macaca mulatta RXRB VGNC VGNC:76952
Mus musculus RXRB MGD MGI:98215
Bos taurus RXRB VGNC VGNC:34231
Rattus norvegicus RXRB RGD RGD:3611
Others RXRB NCBI
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