Ccr2 - C-C motif chemokine receptor 2 Gene

中文名称：CC 基序趋化因子受体 2

种属: Rattus norvegicus

基因 ID: 60463 | 基因类型: protein coding

关于 Ccr2

Primary_assembly 8: 123,734,430-123,742,100 forward strand.mRatBN7.2:CM026981.1

This gene has 2 transcripts (splice variants), 151 orthologues, 24 paralogues and is associated with 93 phenotypes.

mRNA	Protein	Name
NM_021866.2	NP_068638.1	C-C chemokine receptor type 2

基因本体论

分子功能 GO 注释	逻辑证据	参考文献	来源
enables identical protein binding	IPI IPI: 通过物理相互作用推断	15978006	RGD

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in G protein-coupled receptor signaling pathway	IMP IMP: 通过突变表型推断	18584881	RGD
involved in blood vessel remodeling	IEP IEP: 通过表达模式推断	15178559	RGD
involved in chemokine-mediated signaling pathway	IMP IMP: 通过突变表型推断	18584881	RGD
involved in cytokine-mediated signaling pathway	IMP IMP: 通过突变表型推断	16174730	RGD
involved in inflammatory response to antigenic stimulus	IEP IEP: 通过表达模式推断	14674010	RGD
involved in intracellular calcium ion homeostasis	IDA IDA: 通过直接分析推断	15978006	RGD
involved in positive regulation of NMDA glutamate receptor activity	IGI IGI: 通过遗传相互作用推断	27094552	RGD
involved in positive regulation of p38MAPK cascade	IDA IDA: 通过直接分析推断	18584881	RGD
involved in positive regulation of tumor necrosis factor production	IMP IMP: 通过突变表型推断	24826069	RGD
involved in response to hyperoxia	IEP IEP: 通过表达模式推断	21404274	RGD
involved in response to hypoxia	IEP IEP: 通过表达模式推断	18446360	RGD

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in dendrite	IDA IDA: 通过直接分析推断	15978006	RGD
located in neuronal cell body	IDA IDA: 通过直接分析推断	15978006	RGD
located in perikaryon	IDA IDA: 通过直接分析推断	16196033	RGD
located in perinuclear region of cytoplasm	IDA IDA: 通过直接分析推断	15978006	RGD
located in primary dendrite	IDA IDA: 通过直接分析推断	16196033	RGD

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

7tmA_CCR5_CCR2

蛋白主名

其他名称

C-C chemokine receptor type 2

Approval

生物活性分子 (2)

目录号	产品名	作用方式	纯度	是否罕见病
HY-117621	PF-04634817	Antagonist	98.87%	否
HY-117621A	PF-04634817 succinate	Antagonist	99.50%	否

Clinical Phase

生物活性分子 (4)

目录号	产品名	作用方式	纯度	Phase
HY-14882	Cenicriviroc	Antagonist	99.01%	Phase 3
HY-14882A	Cenicriviroc Mesylate	Antagonist	99.04%	Phase 3
HY-13245	PF-4136309	Antagonist	99.79%	Phase 2
HY-109593	BMS-813160	Antagonist	99.93%	Phase 2

抗体抑制剂 (1)

目录号	产品名	作用方式	纯度	Phase
HY-P99781	Plozalizumab	Inhibitor	95.00%	Phase 2

Pre-clinical Phase

生物活性分子 (22)

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-15418	RS 504393	Antagonist	99.34%	否
HY-50674	INCB3344	Antagonist	99.73%	否
HY-13406	TAK-779	Antagonist	99.73%	否
HY-18611	RS102895 hydrochloride	Antagonist	99.87%	否
HY-18611A	RS102895	Antagonist	99.97%	否
HY-103362	CCR2 antagonist 4 hydrochloride	Antagonist	99.86%	否
HY-50669A	MK-0812 Succinate	Antagonist	99.90%	是
HY-50081	CCR2-RA-[R]	Antagonist	99.71%	否
HY-15450A	INCB 3284	Antagonist	99.30%	否
HY-101908	BMS CCR2 22	Antagonist	99.87%	否
HY-112792	CCR2 antagonist 1	Antagonist	98.00%	否
HY-108323	CCR2 antagonist 4	Antagonist	99.89%	否
HY-101713	Ilacirnon	Inhibitor	99.87%	否
HY-135891	AZD2423	Antagonist	99.91%	否
HY-103355	YM022	Antagonist	99.93%	否
HY-50669	MK-0812	Antagonist	99.75%	是
HY-101264	CCR2 antagonist 3	Antagonist	99.84%	否
HY-13499	JNJ-41443532	Inhibitor	99.65%	否
HY-50674A	INCB3344 R-isomer		97.04%	否
HY-15450	INCB 3284 dimesylate	Antagonist	≥98.0%	否
HY-108432	BMS-741672	Antagonist	/	否
HY-110132	JNJ-27141491	Antagonist	/	否

种属	基因名	来源	基因 ID
Homo sapiens	Ccr2	NCBI	NCBI:729230
Mus musculus	Ccr2	NCBI	NCBI:12772

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。	站点地图隐私声明
沪ICP备15051369号-4 上海工商沪公网安备31011502019417 沪(浦)应急管危经许[2021]201709(QFYS) 营业执照（三证合一）
Copyright © 2013-2024 MedChemExpress. All Rights Reserved.

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明