Ccr2 - chemokine (C-C motif) receptor 2 Gene

中文名称：趋化因子 (CC 基序) 受体 2

种属: Mus musculus

同用名: Ckr2; Ccr2a; Ccr2b; Ckr2a; Ckr2b; mJe-r; Cmkbr2; Cc-ckr-2

关于 Ccr2

功能概要

该基因编码的蛋白可启动 CC 趋化因子结合活性和 CC 趋化因子受体活性。参与多个过程，包括白细胞迁移；细胞迁移的正调控；和调节细胞因子的产生。作用于多个过程的上游或内部，包括细胞防御反应；单核细胞趋化性；和中性粒细胞清除率。位于质膜外侧。以多种结构表达，包括消化系统；脑;泌尿生殖系统；淋巴系统腺体；以及肝脏和胆道系统。用于研究冠状病毒传染病和年龄相关性黄斑变性。该基因的人类直系同源物与多种疾病有关，包括川崎病；侵袭性牙周炎;冠状动脉疾病（多发性）；糖代谢疾病（多种）；和葡萄膜炎（多发）。与人 CCR2（CC 基序趋化因子受体 2）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables C-C chemokine binding activity and C-C Chemokine Receptor activity. Involved in several processes, including leukocyte migration; positive regulation of cell migration; and regulation of cytokine production. Acts upstream of or within several processes, including cellular defense response; monocyte chemotaxis; and neutrophil clearance. Located in external side of plasma membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and liver and biliary system. Used to study Coronavirus infectious disease and age related macular degeneration. Human ortholog(s) of this gene implicated in several diseases, including Kawasaki disease; aggressive periodontitis; coronary artery disease (multiple); glucose metabolism disease (multiple); and uveitis (multiple). Orthologous to human CCR2 (C-C motif Chemokine Receptor 2). [provided by Alliance of Genome Resources, Apr 2022]