2. Gene
  3. RPE - ribulose-5-phosphate-3-epimerase Gene

RPE - ribulose-5-phosphate-3-epimerase Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：5-磷酸核酮糖 3-差向异构酶

种属: Homo sapiens

同用名: RPE2-1

基因 ID: 6120 | 基因类型: protein coding

关于 RPE

Cytogenetic location: 2q34 Genomic coordinates (GRCh38): 2:210,002,638-210,022,260 (from NCBI)

This gene has 16 transcripts (splice variants), 227 orthologues and 1 paralogue. Ubiquitous expression in thyroid (RPKM 5.9), adrenal (RPKM 5.7) and 25 other tissues.

功能概要

启用金属离子结合活性；蛋白质同二聚化活性；和磷酸核酮糖 3-差向异构酶活性。参与碳水化合物代谢过程和磷酸戊糖分流。位于细胞外外泌体。 [由基因组资源联盟提供，2022 年 4 月]

Enables metal ion binding activity; protein homodimerization activity; and ribulose-phosphate 3-epimerase activity. Involved in carbohydrate metabolic process and pentose-phosphate shunt. Located in extracellular exosome. [provided by Alliance of Genome Resources, Apr 2022]

RPE 基因产物(14)

mRNA Protein Name
NM_001278282.2 NP_001265211.1 ribulose-phosphate 3-epimerase isoform 2
NM_001278283.2 NP_001265212.1 ribulose-phosphate 3-epimerase isoform 2
NM_001278285.2 NP_001265214.1 ribulose-phosphate 3-epimerase isoform 3
NM_001278286.2 NP_001265215.1 ribulose-phosphate 3-epimerase isoform 4
NM_001278288.2 NP_001265217.1 ribulose-phosphate 3-epimerase isoform 4
NM_001278289.2 NP_001265218.1 ribulose-phosphate 3-epimerase isoform 5
NM_001318926.2 NP_001305855.1 ribulose-phosphate 3-epimerase isoform 6
NM_001318927.2 NP_001305856.1 ribulose-phosphate 3-epimerase isoform 7
NM_001318928.2 NP_001305857.1 ribulose-phosphate 3-epimerase isoform 8
NM_001318929.2 NP_001305858.1 ribulose-phosphate 3-epimerase isoform 9
NM_001318930.2 NP_001305859.1 ribulose-phosphate 3-epimerase isoform 4
NM_001318931.2 NP_001305860.1 ribulose-phosphate 3-epimerase isoform 4
NM_006916.3 NP_008847.1 ribulose-phosphate 3-epimerase isoform 2
NM_199229.3 NP_954699.1 ribulose-phosphate 3-epimerase isoform 1
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables D-ribulose-phosphate 3-epimerase activity IDA
IDA: 通过直接分析推断
20923965 GOA
enables identical protein binding IPI
IPI: 通过物理相互作用推断
16189514 GOA
enables metal ion binding IDA
IDA: 通过直接分析推断
20923965 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
32296183 GOA
enables protein homodimerization activity IPI
IPI: 通过物理相互作用推断
20923965 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in carbohydrate metabolic process IDA
IDA: 通过直接分析推断
20923965 GOA
involved in pentose-phosphate shunt IDA
IDA: 通过直接分析推断
20923965 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

RPE 蛋白结构

Ribul_P_3_epim

Ribul_P_3_epim: Ribulose-phosphate 3 epimerase family (6 - 203)

  • 0
  • 100
  • 200
  • 228 a.a.
蛋白主名 其他名称

ribulose-phosphate 3-epimerase

RPE 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
RPE Q96AT9 CLU Homo sapiens P10909
Anti Tag CoIP
33961781
种属内
RPE Q96AT9 serB2 Yersinia pestis A0A6B3V8E0
Y2H Pooling
20711500
种属内
RPE Q96AT9 GPX4 Homo sapiens P36969
Anti Tag CoIP
33961781
种属内
RPE Q96AT9 RPE Homo sapiens Q96AT9
Y2H Pooling
16189514
种属内
RPE Q96AT9 PLEKHF2 Homo sapiens Q9H8W4
Validated Y2H
32296183
种属内
RPE Q96AT9 RPE Homo sapiens Q96AT9
Validated Y2H
32296183
种属内
RPE Q96AT9 RPE Homo sapiens Q96AT9
X-Ray Diffraction
20923965
种属内
RPE Q96AT9 RPE Homo sapiens Q96AT9
Y2H Array
25416956
种属内
RPE Q96AT9 APOD Homo sapiens P05090
Anti Tag CoIP
33961781
种属内
RPE Q96AT9 RPE Homo sapiens Q96AT9
Y2H Prey Pooling
32296183
种属内
RPE Q96AT9 GCD7 Saccharomyces cerevisiae P32502
Y2H Array
27107014
种属内
RPE Q96AT9 RPE Homo sapiens Q96AT9
Y2H Array
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 RPE 蛋白

目录号 产品名 蛋白编号 纯度
HY-P71264 RPE Protein, Human (His) Q96AT9-1 (M1-R228) ≥95%
HY-P74592 RPE Protein, Human (HEK293, His) Q96AT9-1/NP_954699.1 (M1-R228) ≥95%

关联疾病

疾病名称 别名
Myasthenic Syndrome, Congenital, 10

Congenital Myasthenic Syndrome 10

CMS10

Lgm

Myasthenia, Limb-Girdle, Familial

Myasthenia, Limb-Girdle, Familial, Formerly

Lgm, Formerly

Congenital Myasthenic Syndrome Type Ib, Formerly

Cms1b, Formerly

Cms Ib, Formerly

Myasthenic Myopathy, Formerly

Familial Limb-Girdle Myasthenia

Cms1b

Cms Ib

Congenital Myasthenic Syndrome Type 1b

Congenital Myasthenic Syndrome Type Ib

Myasthenic Myopathy

Myasthenic Syndrome, Congenital, Type 10

Congenital Myasthenic Syndrome Ib

Myopathy In Myasthenia Gravis
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Approval
生物活性分子 (1)
目录号 产品名 作用方式
纯度 是否罕见病
HY-148457 Avacincaptad pegol Inhibitor / 否
Clinical Phase
生物活性分子 (3)
目录号 产品名 作用方式
纯度 Phase
HY-19720A Emixustat hydrochloride 99.29% Phase 3
HY-19720 Emixustat Inhibitor 98.00% Phase 3
HY-125639 (rac)-AR-13503 Inhibitor 98.01% Phase 1
Pre-clinical Phase
生物活性分子 (20)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-134928A Pyridinium bisretinoid A2E TFA ≥90.0% 否
HY-N0428 Obacunone Inducer 99.75% 否
HY-101019 Ossirene Inhibitor ≥98.0% 否
HY-D0988 R-PE (R-Phycoerythrin) / 否
HY-101293 VU0359595 Inhibitor 99.65% 否
HY-D1742 DRAQ5 Chemical / 否
HY-12462 WS3 98.00% 否
HY-22024 5-Hydroxyflavone 99.83% 否
HY-149325 RPE65-IN-1 ≥98.0% 否
HY-134928 Pyridinium bisretinoid A2E / 否
HY-163684 Zoracopan Inhibitor 99.85% 否
HY-P5169A LVGRQLEEFL (mouse) (TFA) 98.20% 否
HY-151872 HDAC-IN-48 / 否
HY-162904 BPU17 / 否
HY-N11499 Myricetin 3-O-α-L-arabinopyranoside Inhibitor / 否
HY-P4253 Arginyl-Glutamine Inhibitor / 否
HY-P5169 LVGRQLEEFL (mouse) / 否
HY-RS12150 RPE Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS12151 RPE65 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-D2396 Sulfo SMCC R-phycoerythrin / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus RPE MGD MGI:1913896
Rattus norvegicus RPE RGD RGD:1564890
Macaca mulatta RPE NCBI NCBI:711322
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