2. Gene
  3. RPL31 - ribosomal protein L31 Gene

RPL31 - ribosomal protein L31 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：核糖体蛋白 L31

种属: Homo sapiens

同用名: L31

基因 ID: 6160 | 基因类型: protein coding

关于 RPL31

Cytogenetic location: 2q11.2 Genomic coordinates (GRCh38): 2:101,002,289-101,019,724 (from NCBI)

This gene has 11 transcripts (splice variants), 157 orthologues and is associated with 1 phenotype. Ubiquitous expression in ovary (RPKM 450.2), bone marrow (RPKM 284.8) and 25 other tissues.

功能概要

核糖体是催化蛋白质合成的细胞器，由一个小的 40S 亚基和一个大的 60S 亚基组成。这些亚基一起由 4 种 RNA 和大约 80 种结构不同的蛋白质组成。该基因编码的核糖体蛋白是 60S 亚基的一个组成部分。该蛋白属于核糖体蛋白 L31E 家族。它位于细胞质中。已经观察到与匹配的正常组织相比，该基因在家族性腺瘤性息肉中的表达水平更高。作为典型的编码核糖体蛋白的基因，该基因有多个经过处理的假基因分散在基因组中。已发现该基因编码不同亚型的可变剪接转录物变体。[RefSeq 提供，2008 年 7 月]

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L31E family of ribosomal proteins. It is located in the cytoplasm. Higher levels of expression of this gene in familial adenomatous polyps compared to matched normal tissues have been observed. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

RPL31 基因产物(3)

mRNA Protein Name
NM_000993.5 NP_000984.1 60S ribosomal protein L31 isoform 1
NM_001098577.3 NP_001092047.1 60S ribosomal protein L31 isoform 2
NM_001099693.2 NP_001093163.1 60S ribosomal protein L31 isoform 3
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
24725430 GOA
enables structural constituent of ribosome IDA
IDA: 通过直接分析推断
23636399 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cytoplasmic translation IDA
IDA: 通过直接分析推断
25957688 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of cytosolic large ribosomal subunit IDA
IDA: 通过直接分析推断
25957688 GOA
part of cytosolic large ribosomal subunit IPI
IPI: 通过物理相互作用推断
25901680 GOA
located in cytosolic ribosome IDA
IDA: 通过直接分析推断
23636399 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

RPL31 蛋白结构

Ribosomal_L31e

Ribosomal_L31e: Ribosomal protein L31e (18 - 101)

  • 0
  • 100
  • 125 a.a.
蛋白主名 其他名称

60S ribosomal protein L31

large ribosomal subunit protein eL31

RPL31 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属间
RPL31 P62899 N SARS-CoV-2 P0DTC9
Y2H Array
36217030
种属内
RPL31 P62899 q9y649_human Homo sapiens Q9Y649
Y2H Array
32814053
种属内
RPL31 P62899 q9y649_human Homo sapiens Q9Y649
Validated Y2H
32814053
种属内
RPL31 P62899 q9y649_human Homo sapiens Q9Y649
Y2H Pooling
32814053
种属内
RPL31 P62899 FGFR3 Homo sapiens P22607
Validated Y2H
32814053
种属内
RPL31 P62899 FGFR3 Homo sapiens P22607
Y2H Array
32814053
种属内
RPL31 P62899 FGFR3 Homo sapiens P22607
Y2H Pooling
32814053
种属内
RPL31 P62899 GSN Homo sapiens P06396
Y2H Pooling
32814053
种属内
RPL31 P62899 GSN Homo sapiens P06396
Validated Y2H
32814053
种属内
RPL31 P62899 GSN Homo sapiens P06396
Y2H Array
32814053
种属内
RPL31 P62899 CTCF Homo sapiens P49711
Anti Tag CoIP
33961781
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Diamond-Blackfan Anemia

Congenital Pure Red Cell Aplasia

Aase Syndrome

Erythrogenesis Imperfecta

Anemia, Diamond-Blackfan

Congenital Hypoplastic Anemia

Aase-Smith Ii Syndrome

Bds

Blackfan-Diamond Anemia

Congenital Prca

Congenital Hypoplastic Anemia, Blackfan-Diamond Type

Dba

Blackfan - Diamond Syndrome

Chronic Constitutional Pure Red Cell Anaemia

Anemia Diamond Blackfan Type

Anemia Congenital Erythroid Hypoplastic

Aregenerative Anemia Chronic Congenital

Blackfan Diamond Syndrome

Red Cell Aplasia, Pure Hereditary

Aase-Smith Syndrome Ii

Bda

Blackfan Diamond Anemia

Blackfan-Diamond Disease

Blackfan-Diamond Syndrome

Chronic Congenital Agenerative Anemia

Congenital Erythroid Hypoplastic Anemia

Congenital Hypoplastic Anemia Of Blackfan And Diamond

Congenital Pure Red Cell Anemia

Hypoplastic Congenital Anemia

Inherited Erythroblastopenia

Pure Hereditary Red Cell Aplasia

Anemia, Hypoplastic, Congenital

Anemia Hypoplastic Congenital

Fanconi Anemia

Constitutional Aplastic Anemia

Diamond-Blackfan Anemia 1

Aase Smith Syndrome 2

Congenital Red Cell Aplasia

Red Cell Aplasia Of Infants

Pure Red Cell Aplasia Of Infants

Congenital Red Cell Aplastic Anaemia

Congenital Pure Red Cell Anaemia

Congenital Erythroid Hypoplasia

Pearson Marrow-Pancreas Syndrome
Diamond-Blackfan Anemia 6

DBA6

Aase-Smith Syndrome Ii

Aase Syndrome

Aase Smith Syndrome 2

Rpl5-Related Diamond-Blackfan Anemia

Anemia, Diamond-Blackfan, Type 6

Diamond-Blackfan Anemia 1
Retinitis Pigmentosa 23

RP23

Retinitis Pigmentosa-23

Retinitis Pigmentosa, Type 23

Rp23 Gene
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS12186 RPL31 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus RPL31 VGNC VGNC:81212
Mus musculus RPL31 MGD MGI:2149632
Rattus norvegicus RPL31 RGD RGD:621202
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