1. Gene
  2. RPS9 - ribosomal protein S9 Gene

RPS9 - ribosomal protein S9 Gene

中文名称:核糖体蛋白 S9

种属: Homo sapiens

同用名: S9

基因 ID: 6203 | 基因类型: protein coding

关于 RPS9

Cytogenetic location: 19q13.42 Genomic coordinates (GRCh38): 19:54,200,858-54,207,647 (from NCBI)

This gene has 13 transcripts (splice variants), 1 gene allele and 190 orthologues. Ubiquitous expression in ovary (RPKM 603.9), bone marrow (RPKM 379.2) and 25 other tissues.

功能概要

核糖体是催化蛋白质合成的细胞器,由一个小的 40S 亚基和一个大的 60S 亚基组成。这些亚基一起由 4 种 RNA 和大约 80 种结构不同的蛋白质组成。该基因编码的核糖体蛋白是 40S 亚基的一个组成部分。该蛋白属于核糖体蛋白的 S4P 家族。它位于细胞质中。与邻近的正常组织相比,已观察到该基因在结直肠癌中的可变表达,尽管尚未发现表达水平与疾病严重程度之间的相关性。与编码核糖体蛋白的基因一样,源自该基因的多个加工假基因分散在基因组中。[RefSeq 提供,2008 年 7 月]

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S4P family of ribosomal proteins. It is located in the cytoplasm. Variable expression of this gene in colorectal cancers compared to adjacent normal tissues has been observed, although no correlation between the level of expression and the severity of the disease has been found. As is typical for genes encoding ribosomal proteins, multiple processed pseudogenes derived from this gene are dispersed through the genome. [provided by RefSeq, Jul 2008]

RPS9 基因产物(6)

mRNA Protein Name
NM_001013.4 NP_001004.2 40S ribosomal protein S9 isoform a
NM_001321701.2 NP_001308630.1 40S ribosomal protein S9 isoform a
NM_001321702.2 NP_001308631.1 40S ribosomal protein S9 isoform a
NM_001321704.2 NP_001308633.1 40S ribosomal protein S9 isoform a
NM_001321705.2 NP_001308634.1 40S ribosomal protein S9 isoform b
NM_001321706.2 NP_001308635.1 40S ribosomal protein S9 isoform c
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
18420587 GOA
enables structural constituent of ribosome IDA
IDA: 通过直接分析推断
23636399 GOA
enables translation regulator activity IMP
IMP: 通过突变表型推断
18420587 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in positive regulation of cell population proliferation IMP
IMP: 通过突变表型推断
18420587 GOA
involved in ribosomal small subunit biogenesis IDA
IDA: 通过直接分析推断
34516797 GOA
involved in translation IMP
IMP: 通过突变表型推断
18420587 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
18420587 GOA
located in cytosolic ribosome IDA
IDA: 通过直接分析推断
23636399 GOA
part of cytosolic small ribosomal subunit IDA
IDA: 通过直接分析推断
8706699 GOA
located in nucleolus IDA
IDA: 通过直接分析推断
18420587 GOA
part of ribonucleoprotein complex IDA
IDA: 通过直接分析推断
17289661 GOA
part of small-subunit processome IDA
IDA: 通过直接分析推断
34516797 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

RPS9 蛋白结构

Ribosomal_S4

Ribosomal_S4: Ribosomal protein S4/S9 N-terminal domain (7 - 107)

S4

S4: S4 domain (108 - 151)

  • 0
  • 100
  • 194 a.a.
蛋白主名 其他名称

40S ribosomal protein S9

small ribosomal subunit protein uS4

RPS9 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
RPS9 P46781 RPS2 Homo sapiens P15880
Crosslink
30021884
种属内
RPS9 P46781 STAT3 Homo sapiens P40763
Y2H
21988832
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Takayasu Arteritis

Aortic Arch Syndrome

Pulseless Disease

Takayasu'S Arteritis

Idiopathic Aortitis

Young Female Arteritis

Aortic Arch Arteritis

Aortic Arches Defect

Aortic Arch Defects

Takayasu Disease

Aortic Arch Syndromes

Takayasu'S Disease

Ta

Obliterative Aortitis

Aortic Arch Giant-Cell Arteritis

Subclavian-Carotid Obstruction Syndrome

Idiopathic Medial Aortopathy And Arteriopathy

Takayasu Syndrome

Obliterative Brachiocephalic Arteritis Syndrome

Raeder-Harbitz Syndrome

Chronic Subclavian-Carotid Obstruction Syndrome

Giant-Cell Aortitis

Takayasu Aortitis

Nonspecific Aortoarteritis

Sclerosing Aortitis And Arteritis

Martorell 2 Syndrome

Young Female Aortic Arch Arteritis Syndrome

Diamond-Blackfan Anemia

Congenital Pure Red Cell Aplasia

Aase Syndrome

Erythrogenesis Imperfecta

Anemia, Diamond-Blackfan

Congenital Hypoplastic Anemia

Aase-Smith Ii Syndrome

Bds

Blackfan-Diamond Anemia

Congenital Prca

Congenital Hypoplastic Anemia, Blackfan-Diamond Type

Dba

Blackfan - Diamond Syndrome

Chronic Constitutional Pure Red Cell Anaemia

Anemia Diamond Blackfan Type

Anemia Congenital Erythroid Hypoplastic

Aregenerative Anemia Chronic Congenital

Blackfan Diamond Syndrome

Red Cell Aplasia, Pure Hereditary

Aase-Smith Syndrome Ii

Bda

Blackfan Diamond Anemia

Blackfan-Diamond Disease

Blackfan-Diamond Syndrome

Chronic Congenital Agenerative Anemia

Congenital Erythroid Hypoplastic Anemia

Congenital Hypoplastic Anemia Of Blackfan And Diamond

Congenital Pure Red Cell Anemia

Hypoplastic Congenital Anemia

Inherited Erythroblastopenia

Pure Hereditary Red Cell Aplasia

Anemia, Hypoplastic, Congenital

Anemia Hypoplastic Congenital

Fanconi Anemia

Constitutional Aplastic Anemia

Diamond-Blackfan Anemia 1

Aase Smith Syndrome 2

Congenital Red Cell Aplasia

Red Cell Aplasia Of Infants

Pure Red Cell Aplasia Of Infants

Congenital Red Cell Aplastic Anaemia

Congenital Pure Red Cell Anaemia

Congenital Erythroid Hypoplasia

Pearson Marrow-Pancreas Syndrome

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus RPS9 RGD RGD:619889
Felis catus RPS9 VGNC VGNC:64762
Mus musculus RPS9 MGD MGI:1924096
Canis familiaris RPS9 VGNC VGNC:45749
Macaca mulatta RPS9 VGNC VGNC:76936
Bos taurus RPS9 VGNC VGNC:34152