SORT1 - sortilin 1 Gene

中文名称：分拣蛋白 1

种属: Homo sapiens

同用名: NT3; Gp95; NTR3; LDLCQ6

基因 ID: 6272 | 基因类型: protein coding

关于 SORT1

Cytogenetic location: 1p13.3 Genomic coordinates (GRCh38): 1:109,309,575-109,397,918 (from NCBI)

This gene has 10 transcripts (splice variants), 269 orthologues, 4 paralogues and is associated with 1 phenotype. Broad expression in brain (RPKM 47.1), testis (RPKM 30.3) and 22 other tissues.

功能概要

该基因编码与 VPS10 相关的 sortilin 蛋白家族成员。编码的前原蛋白由弗林蛋白酶进行蛋白水解处理以产生成熟受体。该受体在将不同蛋白质运输到细胞表面或亚细胞区室 (如溶酶体和核内体) 中发挥作用。该基因的表达水平可能影响人类患者心肌梗塞的风险。可变剪接导致多个转录本变体。[RefSeq 提供，2015 年 10 月]

This gene encodes a member of the VPS10-related sortilin family of proteins. The encoded preproprotein is proteolytically processed by Furin to generate the mature receptor. This receptor plays a role in the trafficking of different proteins to either the cell surface, or subcellular compartments such as lysosomes and endosomes. Expression levels of this gene may influence the risk of myocardial infarction in human patients. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015]

SORT1 基因产物(2)

mRNA	Protein	Name
NM_001205228.2	NP_001192157.1	sortilin isoform 2
NM_002959.7	NP_002950.3	sortilin isoform 1 preproprotein

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables enzyme binding	IPI IPI: 通过物理相互作用推断	10085125	GOA
enables nerve growth factor binding	IPI IPI: 通过物理相互作用推断	14985763	GOA
enables nerve growth factor receptor activity	IDA IDA: 通过直接分析推断	14985763	GOA
enables neurotensin receptor activity, non-G protein-coupled	IDA IDA: 通过直接分析推断	9756851	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	10085125	GOA
enables retromer complex binding	IDA IDA: 通过直接分析推断	18817523	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in D-glucose import	IMP IMP: 通过突变表型推断	15992544	GOA
involved in G protein-coupled receptor signaling pathway	IMP IMP: 通过突变表型推断	18258592	GOA
involved in Golgi to endosome transport	IDA IDA: 通过直接分析推断	11331584	GOA
involved in Golgi to lysosome transport	IDA IDA: 通过直接分析推断	16787399	GOA
involved in endocytosis	IDA IDA: 通过直接分析推断	11331584	GOA
involved in endosome to lysosome transport	IDA IDA: 通过直接分析推断	11331584	GOA
involved in endosome transport via multivesicular body sorting pathway	IDA IDA: 通过直接分析推断	11331584	GOA
involved in extrinsic apoptotic signaling pathway via death domain receptors	IDA IDA: 通过直接分析推断	14985763	GOA
involved in myotube differentiation	IMP IMP: 通过突变表型推断	18258592	GOA
involved in negative regulation of lipoprotein lipase activity	IDA IDA: 通过直接分析推断	10085125	GOA
involved in neuropeptide signaling pathway	IDA IDA: 通过直接分析推断	9756851	GOA
involved in neurotrophin TRK receptor signaling pathway	IMP IMP: 通过突变表型推断	14985763	GOA
involved in plasma membrane to endosome transport	IDA IDA: 通过直接分析推断	11331584	GOA
involved in regulation of gene expression	IMP IMP: 通过突变表型推断	18258592	GOA
involved in response to insulin	IMP IMP: 通过突变表型推断	15992544	GOA
involved in vesicle organization	IDA IDA: 通过直接分析推断	15992544	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in Golgi apparatus	IDA IDA: 通过直接分析推断	11331584	GOA
located in cell surface	IDA IDA: 通过直接分析推断	10085125	GOA
located in clathrin-coated pit	IDA IDA: 通过直接分析推断	11331584	GOA
located in clathrin-coated vesicle	IDA IDA: 通过直接分析推断	11331584	GOA
located in cytoplasmic vesicle	IDA IDA: 通过直接分析推断	9756851	GOA
located in early endosome	IDA IDA: 通过直接分析推断	11331584	GOA
located in endosome membrane	IDA IDA: 通过直接分析推断	18817523	GOA
located in lysosome	IDA IDA: 通过直接分析推断	28541286	GOA
located in membrane	IDA IDA: 通过直接分析推断	15992544	GOA
located in perinuclear region of cytoplasm	IDA IDA: 通过直接分析推断	11331584	GOA
located in plasma membrane	IDA IDA: 通过直接分析推断	11331584	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

蛋白主名

其他名称

sortilin

100 kDa NT receptor

SORT1 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	SORT1	Q99523	NTRK1	Homo sapiens	P04629	IF	21102451
种属内	SORT1	Q99523	NGF	Homo sapiens	P01138	Crosslink	14985763
种属内	SORT1	Q99523	NGF	Homo sapiens	P01138	SPR	19122660
种属内	SORT1	Q99523	NGF	Homo sapiens	P01138	SPR	14985763
种属内	SORT1	Q99523	CNTF	Homo sapiens	P26441	SPR	20584990
种属内	SORT1	Q99523	CNTF	Homo sapiens	P26441	Confocal	20584990
种属内	SORT1	Q99523	SORCS1	Homo sapiens	Q8WY21	SPR	24128306
种属内	SORT1	Q99523	Q99523-PRO_0000033162	Homo sapiens	Q99523-PRO_0000033162	SPR	24128306
种属内	SORT1	Q99523	Q99523-PRO_0000033162	Homo sapiens	Q99523-PRO_0000033162	SPR	25401472
种属内	SORT1	Q99523	GLA	Homo sapiens	P06280	SPR	21949853
种属间	SORT1	Q99523	Ctf2	Mus musculus	P83714	SPR	20584990
种属间	SORT1	Q99523	Sorcs1	Mus musculus	Q9JLC4	SPR	24128306
种属内	SORT1	Q99523	TG	Homo sapiens	P01266	SPR	18687776
种属内	SORT1	Q99523	NTRK3	Homo sapiens	Q16288	SPR	21102451
种属内	SORT1	Q99523	GGA1	Homo sapiens	Q9UJY5	Y2H	11390366
种属内	SORT1	Q99523	GGA1	Homo sapiens	Q9UJY5	Pull Down	11390366
种属内	SORT1	Q99523	LRPAP1	Homo sapiens	P30533	SPR	20584990
种属内	SORT1	Q99523	LRPAP1	Homo sapiens	P30533	SPR	19122660
种属内	SORT1	Q99523	LRPAP1	Homo sapiens	P30533	SPR	18687776
种属内	SORT1	Q99523	IL6	Homo sapiens	P05231	IF	25401472
种属内	SORT1	Q99523	IL6	Homo sapiens	P05231	Crosslink	25401472
种属内	SORT1	Q99523	IL6	Homo sapiens	P05231	SPR	25401472
种属内	SORT1	Q99523	GRN	Homo sapiens	P28799	Solid Phase Assay	24070898
种属内	SORT1	Q99523	LIFR	Homo sapiens	P42702	PLA	20584990
种属内	SORT1	Q99523	LIFR	Homo sapiens	P42702	SPR	20584990
种属内	SORT1	Q99523	P01138-PRO_0000019599	Homo sapiens	P01138-PRO_0000019599	SPR	14985763
种属间	SORT1	Q99523	Tg	Rattus norvegicus	P06882	SPR	18687776
种属间	SORT1	Q99523	LPL	Bos taurus	P11151	Photoaffinity Labelling	10085125
种属间	SORT1	Q99523	LPL	Bos taurus	P11151	SPR	10085125

种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 SORT1 蛋白

目录号	产品名	蛋白编号	纯度
HY-P78773	Sortilin/SORT1 Protein, Human (HEK293, His)	Q99523-1 (S78-N755)	≥95%

SORT1 抗体

目录号	产品名	应用	反应物种
HY-P83498	Sortilin Antibody (YA3243)	WB, IHC-P	Human, Rat

关联疾病

疾病名称

别名

Low Density Lipoprotein Cholesterol Level Quantitative Trait Locus 6

LDLCQ6

Myocardial Infarction

Heart Attack	Myocardial Infarction, Susceptibility To
Myocardial Infarction 1	Myocardial Infarction, Protection Against
Myocardial Infarction, Decreased Susceptibility To	Myocardial Infarction, Decreased
Myocardial Infarct	MCI1
Premature Myocardial Infarction	Myocardial Infarction, Susceptibility To, Type 1

Fabry Disease

Alpha-Galactosidase A Deficiency	Anderson-Fabry Disease
Angiokeratoma Corporis Diffusum	Ceramide Trihexosidase Deficiency
Fabry Disease, Cardiac Variant	Fabry'S Disease
Hereditary Dystopic Lipidosis	Gla Deficiency
FD	Alpha Galactosidase Deficiency
Deficiency Of Melibiase	Angiokeratoma, Diffuse
Angiokeratoma Diffuse	Diffuse Angiokeratoma

Frontotemporal Dementia

Pallidopontonigral Degeneration	Frontotemporal Lobar Degeneration
Semantic Dementia	FTD
Frontotemporal Lobe Dementia	Multiple System Tauopathy With Presenile Dementia
Dementia, Frontotemporal	Frontotemporal Dementia With Parkinsonism
Mstd	Frontotemporal Lobar Degeneration With Tau Inclusions
Ftld With Tau Inclusions	Dementia, Frontotemporal, With Parkinsonism
Fldem	Ftdp17
Disinhibition-Dementia-Parkinsonism-Amyotrophy Complex	Ddpac
Wilhelmsen-Lynch Disease	Wld
Ppnd	Dementia, Frontotemporal, With Or Without Parkinsonism
Semantic Primary Progressive Aphasia	Semantic Variant Ppa
Wilhemsen-Lynch Disease	Frontotemporal Dementia-Amyotrophic Lateral Sclerosis
Frontotemporal Dementia And Parkinsonism Linked To Chromosome 17	Ftd-Als
Ftld	Pick Complex
Pick Disease Of The Brain	Frontotemporal Dementia With Parkinsonism-17
Grn-Related Frontotemporal Dementia	Frontotemporal Dementia With Motor Neuron Disease
Dementia In Fronto-Temporal Lobar Degeneration	Ftd - [Frontotemporal Dementia]
Temple Dementia	Frontal Lobe Dementia

Essential Tremor

Benign Essential Tremor	Familial Tremor
Hereditary Essential Tremor	Essential Hereditary Tremor
Shaky Hand Syndrome	Benign Essential Tremor Syndrome
Tremor Hereditary Essential	Essential Tremor, Susceptibility To
Tremor, Hereditary Essential

Neuronal Ceroid Lipofuscinosis

Hereditary Ceroid Lipofuscinosis	Batten Disease
Ncl	Neuronal Ceroid-Lipofuscinoses
Lipofuscinosis, Ceroid, Neuronal	Juvenile Neuronal Ceroid Lipofuscinosis
Cerebromacular Dystrophy	Cerebromacular Degeneration
Ceroid-Lipofuscinosis	Ncl - [Neuronal Ceroid Lipofuscinosis]
Amaurotic Familial Idiocy	Amaurotic Idiocy
Amaurotic Idiot	Neuronal Lipofuscinosis
Pigmentary Retinal Lipoid Neuronal Heredodegeneration

Mucolipidosis

Familial Hypercholesterolemia

Hyperlipoproteinemia Type Iia	Familial Hyperbetalipoproteinaemia
Familial Hypercholesteremia	Fredrickson Type Iia Hyperlipoproteinemia
Fredrickson Type Iia Lipidaemia	Hyperbetalipoproteinemia
Type Ii Hyperlipidemia	Familial Hypercholesterolæmia
Familial Hypercholesterolaemia	Fh
Hypercholesterolemia Familial	Hyperlipoproteinemia Type Ii
Hypercholesterolemia, Familial

Parkinson Disease, Late-Onset

Parkinson Disease	Parkinson'S Disease
PD	PARK
Parkinson Disease, Susceptibility To	Late Onset Parkinson'S Disease
Late Onset Parkinson Disease	Paralysis Agitans
Primary Parkinsonism	Idiopathic Parkinson Disease
Parkinson'S	Parkinson Disease, Late-Onset, Susceptibility To
Parkinson Disease, Age Of Onset, Modifier	Lewy Body Parkinson Disease
Idiopathic Parkinson'S Disease	Pd - [Parkinson Disease]
Parkinson Disease Nos	Parkinson, Nos
Primary Parkinson Disease

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-153686	BVFP	Inhibitor	98.12%	否
HY-RS13575	SORT1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-W747072	3-Sulfo-taurocholic Acid Disodium Salt		≥99.0%	否
HY-132975	PrDiAzK	Inhibitor	/	否
HY-153687	SORT-PGRN interaction inhibitor 2	Inhibitor	/	否
HY-159868	SORT1-IN-1	Inhibitor	/	否
HY-159875	SORT1-IN-2	Inhibitor	/	否
HY-159876	SORT1-IN-3	Inhibitor	/	否
HY-159877	SORT1-IN-4	Inhibitor	/	否
HY-159878	SORT1-IN-5	Inhibitor	/	否
HY-D1581	BODIPY 505/515-8-C3-COOH		/	否

直系同源

种属	基因名	来源	基因 ID
Bos taurus	SORT1	VGNC	VGNC:35133
Rattus norvegicus	SORT1	RGD	RGD:619999
Macaca mulatta	SORT1	VGNC	VGNC:77836
Mus musculus	SORT1	MGD	MGI:1338015
Canis familiaris	SORT1	VGNC	VGNC:46664
Felis catus	SORT1	VGNC	VGNC:65575
Others	SORT1	NCBI

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

SORT1 - sortilin 1 Gene

关于 SORT1

功能概要

SORT1 基因产物(2)

SORT1 蛋白互作信息

重组 SORT1 蛋白

SORT1 抗体

关联疾病

直系同源

热门区域

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SORT1 - sortilin 1 Gene

关于 SORT1

功能概要

SORT1 基因产物(2)

SORT1 蛋白互作信息

重组 SORT1 蛋白

SORT1 抗体

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z