2. Gene
  3. S100A10 - S100 calcium binding protein A10 Gene

S100A10 - S100 calcium binding protein A10 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：S100 钙结合蛋白 A10

种属: Homo sapiens

同用名: 42C; P11; p10; GP11; ANX2L; CAL1L; CLP11; Ca[1]; ANX2LG

基因 ID: 6281 | 基因类型: protein coding

关于 S100A10

Cytogenetic location: 1q21.3 Genomic coordinates (GRCh38): 1:151,982,915-151,993,859 (from NCBI)

This gene has 4 transcripts (splice variants), 246 orthologues and 21 paralogues. Broad expression in colon (RPKM 299.3), esophagus (RPKM 210.9) and 22 other tissues.

功能概要

由该基因编码的蛋白质是包含 2 个 EF 手钙结合基序的 S100 蛋白质家族的成员。 S100 蛋白定位于多种细胞的细胞质和/或细胞核，并参与许多细胞过程的调节，例如细胞周期进程和分化。 S100 基因包括至少 13 个成员，它们成簇地位于染色体 1q21 上。这种蛋白质可能在胞吐作用和胞吞作用中起作用。[RefSeq 提供，2008 年 7 月]

The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in exocytosis and endocytosis. [provided by RefSeq, Jul 2008]

S100A10 基因产物(1)

mRNA Protein Name
NM_002966.3 NP_002957.1 protein S100-A10
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
NOT enables lipid binding IDA
IDA: 通过直接分析推断
23861394 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
14699089 GOA
enables protein homodimerization activity IDA
IDA: 通过直接分析推断
23091277 GOA
enables transmembrane transporter binding IPI
IPI: 通过物理相互作用推断
12198146 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in membrane raft assembly IDA
IDA: 通过直接分析推断
23861394 GOA
involved in positive regulation of GTPase activity IMP
IMP: 通过突变表型推断
23129259 GOA
involved in positive regulation of focal adhesion assembly IMP
IMP: 通过突变表型推断
23129259 GOA
involved in positive regulation of plasminogen activation IDA
IDA: 通过直接分析推断
9836589 GOA
involved in positive regulation of stress fiber assembly IMP
IMP: 通过突变表型推断
23129259 GOA
involved in positive regulation of substrate adhesion-dependent cell spreading IMP
IMP: 通过突变表型推断
23129259 GOA
involved in protein localization to plasma membrane IDA
IDA: 通过直接分析推断
12198146 GOA
involved in vesicle budding from membrane IDA
IDA: 通过直接分析推断
23861394 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of AnxA2-p11 complex IDA
IDA: 通过直接分析推断
23091277 GOA
part of RNA polymerase II transcription regulator complex EXP
EXP: 通过实验结果推断
23415230 GOA
colocalizes with membrane raft IDA
IDA: 通过直接分析推断
14699089 GOA
located in plasma membrane IDA
IDA: 通过直接分析推断
3126079 GOA
part of plasma membrane protein complex IPI
IPI: 通过物理相互作用推断
9886297 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

S100A10 蛋白结构

S_100

S_100: S-100/ICaBP type calcium binding domain (5 - 45)

  • 0
  • 97 a.a.
蛋白主名 其他名称

protein S100-A10

S100 calcium binding protein A10 (annexin II ligand, calpactin I, light polypeptide (p11))

S100A10 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
S100A10 P60903 ZGPAT Homo sapiens Q8N5A5-2
Validated Y2H
32296183
种属内
S100A10 P60903 HLTF Homo sapiens Q14527
Pull Down
23415230
种属内
S100A10 P60903 TRPM4 Homo sapiens Q8TD43
FPS
31837246
种属内
S100A10 P60903 S100Z Homo sapiens Q8WXG8
Validated Y2H
32296183
种属内
S100A10 P60903 S100Z Homo sapiens Q8WXG8
Y2H Array
32296183
种属内
S100A10 P60903 S100Z Homo sapiens Q8WXG8
Y2H Prey Pooling
32296183
种属内
S100A10 P60903 MLKL Homo sapiens Q8NB16-2
Y2H Array
32296183
种属内
S100A10 P60903 MLKL Homo sapiens Q8NB16-2
Y2H Prey Pooling
32296183
种属内
S100A10 P60903 MLKL Homo sapiens Q8NB16-2
Validated Y2H
32296183
种属内
S100A10 P60903 AHNAK Homo sapiens Q09666
X-Ray Diffraction
23415230
种属内
S100A10 P60903 ANXA2 Homo sapiens P07355
Crosslink
30021884
种属内
S100A10 P60903 ANXA2 Homo sapiens P07355
Anti Bait CoIP
24457100
种属内
S100A10 P60903 ANXA2 Homo sapiens P07355
IF
24457100
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 S100A10 蛋白

目录号 产品名 蛋白编号 纯度
HY-P74586 S100A10 Protein, Human (His) P60903 (P2-K97) ≥95%

关联疾病

疾病名称 别名
Trachea Leiomyoma

Tracheal Neoplasms

Leiomyoma Of The Trachea

Tracheal Neoplasm

Tracheal Leiomyoma
Conjunctival Intraepithelial Neoplasm

Intraepithelial Neoplasia Of Conjunctiva

Conjunctival Intraepithelial Neoplasia
Barrett'S Adenocarcinoma

Barrett Adenocarcinoma

Adenocarcinoma Arising In Barrett'S Mucosa
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-136465 A2ti-1 Inhibitor 99.84% 否
HY-136466 A2ti-2 Inhibitor 99.27% 否
HY-RS12372 S100A10 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus S100A10 MGD MGI:1339468
Rattus norvegicus S100A10 RGD RGD:628655
Bos taurus S100A10 VGNC VGNC:34237
Felis catus S100A10 VGNC VGNC:80348
Macaca mulatta S100A10 VGNC VGNC:106491
Others S100A10 NCBI
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