SAA2 - serum amyloid A2 Gene

中文名称：血清淀粉样蛋白 A2

种属: Homo sapiens

同用名: SAA; SAA1

基因 ID: 6289 | 基因类型: protein coding

关于 SAA2

Cytogenetic location: 11p15.1 Genomic coordinates (GRCh38): 11:18,238,236-18,248,668 (from NCBI)

This gene has 6 transcripts (splice variants), 140 orthologues and 3 paralogues. Biased expression in liver (RPKM 216.6), fat (RPKM 172.8) and 1 other tissue.

功能概要

该基因编码血清淀粉样蛋白 A 载脂蛋白家族的成员。编码的前原蛋白经过蛋白水解处理以生成成熟蛋白。该蛋白是一种主要的急性期蛋白，在对炎症和组织损伤的反应中高度表达。这种蛋白质还在 HDL 代谢和胆固醇稳态中发挥重要作用。高水平的这种蛋白质与慢性炎症性疾病有关，包括动脉粥样硬化、类风湿性关节炎、阿尔茨海默病和克罗恩病。这种蛋白质也可能是某些肿瘤的潜在生物标志物。最后，针对金黄色葡萄球菌和大肠杆菌的抗菌活性存在于成熟蛋白的 N 末端部分。[RefSeq 提供，2020 年 7 月]

This gene encodes a member of the serum amyloid A family of apolipoproteins. The encoded preproprotein is proteolytically processed to generate the mature protein. This protein is a major acute phase protein that is highly expressed in response to inflammation and tissue injury. This protein also plays an important role in HDL metabolism and Cholesterol homeostasis. High levels of this protein are associated with chronic inflammatory diseases including atherosclerosis, rheumatoid arthritis, Alzheimer's disease and Crohn's disease. This protein may also be a potential biomarker for certain tumors. Finally, antimicrobial activity against S. aureus and E. coli resides in the N-terminal portion of the mature protein. [provided by RefSeq, Jul 2020]

SAA2 基因产物(10)

mRNA	Protein	Name
NM_001127380.3	NP_001120852.1	serum amyloid A-2 protein isoform b preproprotein
NM_001385666.1	NP_001372595.1	serum amyloid A-2 protein isoform a preproprotein
NM_001385667.1	NP_001372596.1	serum amyloid A-2 protein isoform b preproprotein
NM_001385668.1	NP_001372597.1	serum amyloid A-2 protein isoform c preproprotein
NM_001385669.1	NP_001372598.1	serum amyloid A-2 protein isoform d preproprotein
NM_001385670.1	NP_001372599.1	serum amyloid A-2 protein isoform e preproprotein
NM_001385671.1	NP_001372600.1	serum amyloid A-2 protein isoform f
NM_001385672.1	NP_001372601.1	serum amyloid A-2 protein isoform g preproprotein
NM_001385673.1	NP_001372602.1	serum amyloid A-2 protein isoform h
NM_030754.5	NP_110381.2	serum amyloid A-2 protein isoform a preproprotein

基因本体论

分子功能

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	32296183	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

SAA2 蛋白结构

SAA

0
100
122 a.a.

蛋白主名

其他名称

serum amyloid A-2 protein

Serum amyloid A-1 protein

重组 SAA2 蛋白

目录号	产品名	蛋白编号	纯度
HY-P70985	SAA2 Protein, Human (His)	AAH20795.1 (R19-Y122)	≥95%

关联疾病

疾病名称

别名

Amyloidosis

Amyloid Disease	Amyloid
Amyloid Degeneration	Amyloidosis Nos
Amyloid Deposition	Amyloid Infiltration
Idiopathic Amyloidosis	Hyaloid Degeneration
Lardaceous Degeneration

Serum Amyloid A Amyloidosis

Aa Amyloidosis	Secondary Amyloidosis
Reactive Systemic Amyloidosis	Apo Serum Amyloid A Amyloidosis
Inflammation Aa Amyloidosis	Amyloidosis Aa
Amyloid A Amyloidosis	Inflammatory Amyloidosis
Reactive Amyloidosis	Amyloidosis Secondary
Secondary Systemic Amyloidosis	Amyloid Aa

Familial Mediterranean Fever

Periodic Fever Syndrome	FMF
Benign Paroxysmal Peritonitis	Periodic Disease
Recurrent Polyserositis	Familial Paroxysmal Polyserositis
Periodic Fever	Familial Mediterranean Fever, Autosomal Recessive
Familial Mediterranean Fever, Ar	Polyserositis, Recurrent
Polyserositis, Familial Paroxysmal	Periodic Peritonitis
Mef	Reimann Periodic Disease
Siegal-Cattan-Mamou Disease	Wolff Periodic Disease
Benign Recurrent Polyserositis	Mediterranean Fever, Familial
ARFMF	Autosomal Recessive Familial Mediterranean Fever
Fever, Mediterranean, Familial, Autosomal Recessive	Hereditary Autoinflammatory Diseases
Fmf - [Familial Mediterranean Fever]	Periodic Polyserositis
Periodic Familial Polyserositis	Periodic Familial Peritonitis
Paroxysmal Polyserositis	Hereditary Amyloid Nephropathy
Familial Recurrent Polyserositis	Familial Non-Neuropathic Amyloidosis
Armenian Disease	Riemann Periodic Disease
Siegal Cattan Mamou Disease

Crohn'S Disease

Crohn Disease	Pediatric Crohn'S Disease
Regional Enteritis	Crohn'S Disease Of Large Bowel
Granulomatous Colitis	Enteritis, Granulomatous
Enteritis	Crohn'S Disease Of Colon
Colitis, Granulomatous	Crohn'S Enteritis
Enteritis, Regional	Ileitis
Adenoviral Enteritis	Acute Gastroenteropathy Due To Norwalk Agent
Viral Gastroenteritis Due To Norwalk Agent	Winter Vomiting
Epidemic Winter Vomiting Disease	Small Round Structured Virus Enteritis
Epidemic Vomiting Syndrome	Epidemic Vomiting
Epidemic Nausea	Epidemic Viral Gastroenteritis Due To Norwalk Virus
Noroviral Enteritis	Crohn Disease Nos
Crohns	Cd - [Crohn'S Disease]
Regional Enteritis Of Bowel	Crohn'S Regional Enteritis
Cobble-Stone Appearance Of Intestine	Intestinal Ulcer And Erosion Due To Crohn Disease
Granulomatous Enteritis

Amyloidosis, Familial Visceral

Ostertag Type Amyloidosis	German Type Amyloidosis
Familial Renal Amyloidosis	Amyloidosis Viii
Amyloidosis, 3 Or More Types	Familial Visceral Amyloidosis
Familial Amyloid Nephropathy	Hereditary Amyloid Nephropathy
Amyloidosis, Familial Renal	Amyloidosis, Systemic Nonneuropathic
Amyloidosis Familial Visceral	Amyloidosis 8
Amyloidosis, Ostertag Type	Hereditary Amyloidosis With Primary Renal Involvement
Hereditary Renal Amyloidosis	Renal Amyloidosis
Amyloidosis, Renal	Systemic Nonneuropathic Amyloidosis
Amyloidosis Familial Renal	Amyloidosis Systemic Nonneuropathic
Hereditary Amyloidosis With Primary Renal Involement	AMYL8
Systemic Non-Neuropathic Amyloidosis	Amyloid Nephropathy

Rheumatoid Arthritis

RA	Arthritis, Rheumatoid
Rheumatoid Arthritis, Susceptibility To	Arthritis Or Polyarthritis, Rheumatic
Atrophic Arthritis	Rheumatism Arthritis
Rheumatoid Polyarthritis

Cardiomyopathy, Dilated, 1e

Left Ventricular Noncompaction 9	Left Ventricular Noncompaction 5
Dilated Cardiomyopathy 1e	Dilated Cardiomyopathy 1s
CMD1E	Cdcd2
Cardiomyopathy, Dilated, 1y	CMD1Y
Cardiomyopathy, Dilated, 1s	CMD1S
Dilated Cardiomyopathy 1y	Dilated Cardiomyopathy With Conduction Defect 2
Dilated Cardiomyopathy With Conduction Disorder And Arrhythmia	Cardiomyopathy, Dilated, With Conduction Disorder And Arrhythmia
Cardiomyopathy, Dilated, With Conduction Defect 2	Cardiomyopathy Dilated With Conduction Defect Type 2
Cardiomyopathy, Dilated 1e	Cardiomyopathy, Dilated 1s
Cardiomyopathy, Dilated 1y	Left Ventricular Non-Compaction 5
LVNC5	Left Ventricular Non-Compaction 9
LVNC9	Cardiomyopathy, Dilated, Type 1e
Cardiomyopathy, Dilated, Type 1s	Cardiomyopathy, Dilated, Type 1y

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS12407	SAA2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Others	SAA2	NCBI

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

SAA2 - serum amyloid A2 Gene

关于 SAA2

功能概要

SAA2 基因产物(10)

SAA2 蛋白结构

重组 SAA2 蛋白

关联疾病

直系同源

热门区域

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SAA2 - serum amyloid A2 Gene

关于 SAA2

功能概要

SAA2 基因产物(10)

SAA2 蛋白结构

重组 SAA2 蛋白

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z