BICD1 - BICD cargo adaptor 1 Gene

中文名称：BICD 货物适配器 1

种属: Homo sapiens

同用名: BICD; bic-D 1

基因 ID: 636 | 基因类型: protein coding

关于 BICD1

Cytogenetic location: 12p11.21 Genomic coordinates (GRCh38): 12:32,106,847-32,383,633 (from NCBI)

This gene has 10 transcripts (splice variants), 268 orthologues and 1 paralogue. Broad expression in ovary (RPKM 4.3), brain (RPKM 3.8) and 20 other tissues.

功能概要

该基因编码属于双尾 D 家族动力蛋白货物适配器的适配器蛋白。编码的蛋白质作为细胞内货物运输辅助因子，调节基于微管的货物装载到动力蛋白运动复合体上。它还控制动力蛋白运动活动和协调。它具有由 N 和 C 末端的卷曲螺旋结构域组成的结构域结构，这些结构域在其他家族成员中高度保守。该基因中自然发生的突变与短端粒长度和肺气肿有关。[RefSeq 提供，2017 年 8 月]

This gene encodes an adaptor protein that belongs to the bicaudal D family of dynein cargo adaptors. The encoded protein acts as an intracellular cargo transport cofactor that regulates the microtubule-based loading of cargo onto the dynein motor complex. It also controls dynein motor activity and coordination. It has a domain architecture consisting of coiled-coil domains at the N- and C-termini that are highly conserved in Other family members. Naturally occurring mutations in this gene are associated with short telomere length and emphysema. [provided by RefSeq, Aug 2017]

BICD1 基因产物(34)

mRNA	Protein	Name
NM_001003398.3	NP_001003398.1	protein bicaudal D homolog 1 isoform 2
NM_001354186.2	NP_001341115.1	protein bicaudal D homolog 1 isoform 3
NM_001354187.2	NP_001341116.1	protein bicaudal D homolog 1 isoform 4
NM_001354188.2	NP_001341117.1	protein bicaudal D homolog 1 isoform 5
NM_001354189.2	NP_001341118.1	protein bicaudal D homolog 1 isoform 6
NM_001363603.2	NP_001350532.1	protein bicaudal D homolog 1 isoform 7
NM_001413155.1	NP_001400084.1	protein bicaudal D homolog 1 isoform 2
NM_001413156.1	NP_001400085.1	protein bicaudal D homolog 1 isoform 8
NM_001413157.1	NP_001400086.1	protein bicaudal D homolog 1 isoform 9
NM_001413158.1	NP_001400087.1	protein bicaudal D homolog 1 isoform 10
NM_001413159.1	NP_001400088.1	protein bicaudal D homolog 1 isoform 11
NM_001413160.1	NP_001400089.1	protein bicaudal D homolog 1 isoform 12
NM_001413161.1	NP_001400090.1	protein bicaudal D homolog 1 isoform 13
NM_001413163.1	NP_001400092.1	protein bicaudal D homolog 1 isoform 14
NM_001413164.1	NP_001400093.1	protein bicaudal D homolog 1 isoform 15
NM_001413165.1	NP_001400094.1	protein bicaudal D homolog 1 isoform 16
NM_001413166.1	NP_001400095.1	protein bicaudal D homolog 1 isoform 17
NM_001413167.1	NP_001400096.1	protein bicaudal D homolog 1 isoform 18
NM_001413168.1	NP_001400097.1	protein bicaudal D homolog 1 isoform 19
NM_001413169.1	NP_001400098.1	protein bicaudal D homolog 1 isoform 20
NM_001413170.1	NP_001400099.1	protein bicaudal D homolog 1 isoform 21
NM_001413171.1	NP_001400100.1	protein bicaudal D homolog 1 isoform 22
NM_001413172.1	NP_001400101.1	protein bicaudal D homolog 1 isoform 23
NM_001413173.1	NP_001400102.1	protein bicaudal D homolog 1 isoform 24
NM_001413174.1	NP_001400103.1	protein bicaudal D homolog 1 isoform 25
NM_001413176.1	NP_001400105.1	protein bicaudal D homolog 1 isoform 26
NM_001413177.1	NP_001400106.1	protein bicaudal D homolog 1 isoform 27
NM_001413178.1	NP_001400107.1	protein bicaudal D homolog 1 isoform 28
NM_001413179.1	NP_001400108.1	protein bicaudal D homolog 1 isoform 29
NM_001413180.1	NP_001400109.1	protein bicaudal D homolog 1 isoform 30
NM_001413181.1	NP_001400110.1	protein bicaudal D homolog 1 isoform 31
NM_001413182.1	NP_001400111.1	protein bicaudal D homolog 1 isoform 32
NM_001413183.1	NP_001400112.1	protein bicaudal D homolog 1 isoform 33
NM_001714.4	NP_001705.2	protein bicaudal D homolog 1 isoform 1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables cytoskeletal anchor activity	IDA IDA: 通过直接分析推断	12447383	GOA
enables dynactin binding	IDA IDA: 通过直接分析推断	12447383	GOA
enables dynactin binding	IPI IPI: 通过物理相互作用推断	17139249	GOA
enables dynein complex binding	IDA IDA: 通过直接分析推断	12447383	GOA
enables dynein intermediate chain binding	IDA IDA: 通过直接分析推断	17139249	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	17139249	GOA
enables protein kinase binding	IPI IPI: 通过物理相互作用推断	17139249	GOA
enables small GTPase binding	IPI IPI: 通过物理相互作用推断	12447383	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in minus-end-directed organelle transport along microtubule	IMP IMP: 通过突变表型推断	12447383	GOA
involved in positive regulation of protein localization to centrosome	IGI IGI: 通过遗传相互作用推断	17139249	GOA
involved in positive regulation of receptor-mediated endocytosis	IMP IMP: 通过突变表型推断	20164183	GOA
involved in protein localization to organelle	IDA IDA: 通过直接分析推断	12447383	GOA
involved in regulation of microtubule cytoskeleton organization	IGI IGI: 通过遗传相互作用推断	17139249	GOA
involved in viral process	IMP IMP: 通过突变表型推断	20089649	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
colocalizes with Golgi apparatus	IDA IDA: 通过直接分析推断	17139249	GOA
located in Golgi apparatus	IDA IDA: 通过直接分析推断	17562788	GOA
located in centrosome	IMP IMP: 通过突变表型推断	17139249	GOA
colocalizes with cytoplasmic microtubule	IDA IDA: 通过直接分析推断	20089649	GOA
located in cytoplasmic vesicle	IDA IDA: 通过直接分析推断	12447383	GOA
located in cytosol	IDA IDA: 通过直接分析推断	12447383	GOA
located in membrane	IDA IDA: 通过直接分析推断	12447383	GOA
located in perinuclear region of cytoplasm	IDA IDA: 通过直接分析推断	20089649	GOA
located in perinuclear region of cytoplasm	IMP IMP: 通过突变表型推断	17139249	GOA
located in secretory vesicle	IDA IDA: 通过直接分析推断	20089649	GOA
located in trans-Golgi network	IDA IDA: 通过直接分析推断	12447383	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

BICD1 蛋白结构

BicD

0
200
400
600
800
975 a.a.

蛋白主名

其他名称

protein bicaudal D homolog 1

bicaudal D homolog 1

BICD1 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	BICD1	Q96G01	GSK3B	Homo sapiens	P49841	Anti Bait CoIP	17139249
种属内	BICD1	Q96G01	GSK3B	Homo sapiens	P49841	Anti Tag CoIP	17139249
种属内	BICD1	Q96G01	GSK3B	Homo sapiens	P49841	Density Sedimentation	17139249
种属内	BICD1	Q96G01	GSK3B	Homo sapiens	P49841	Y2H Array	17139249
种属内	BICD1	Q96G01	STAT3	Homo sapiens	P40763	Pull Down	21988832

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Granulomatous Disease, Chronic, Autosomal Recessive, 3

CGD3	Autosomal Recessive Chronic Granulomatous Disease Cytochrome B-Positive Type Iii
Granulomatous Disease, Chronic, Autosomal Recessive, Cytochrome B-Positive, Type 3	Granulomatous Disease, Chronic, Autosomal Recessive, Cytochrome B-Positive, Type Iii
Cgd, Autosomal Recessive Cytochrome B-Positive, Type Iii	Granulomatous Disease, Chronic, Due To Ncf4 Deficiency
Chronic Granulomatous Disease 3, Autosomal Recessive	Autosomal Recessive Chronic Granulomatous Disease 3
Autosomal Recessive Cytochrome B-Positive Cgd Type Iii	Cdg3
Chronic Granulomatous Disease Due To Ncf4 Deficiency	Cgd Autosomal Recessive Cytochrome B-Positive Type Iii
Chronic Granulomatous Disease Autosomal Recessive Cytochrome B-Positive Type Iii	Granulomatous Disease Chronic Due To Ncf4 Deficiency
Granulomatous Disease, Chronic, Autosomal Recessive Cytochrome B-Positive, Type 3

Spinal Muscular Atrophy With Lower Extremity Predominant

Spinal Muscular Atrophy With Lower Extremity Predominance	Autosomal Dominant Childhood-Onset Proximal Spinal Muscular Atrophy With Contractures
Kugelberg-Welander Syndrome, Autosomal Dominant	Lower Extremity-Predominant Autosomal Dominant Proximal Spinal Muscular Atrophy With Contractures
Sma-Led	Spinal Muscular Atrophy, Childhood, Proximal, Autosomal Dominant
Spinal Muscular Atrophy, Juvenile, Proximal, Autosomal Dominant	Spinal Muscular Atrophy, Lower Extremity, Autosomal Dominant
Spinal Muscular Atrophy, Lower Extremity, Dominant

Perry Syndrome

Parkinsonism With Alveolar Hypoventilation And Mental Depression

PERRYS

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS01498	BICD1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Bos taurus	BICD1	VGNC	VGNC:26491
Mus musculus	BICD1	MGD	MGI:1101760
Rattus norvegicus	BICD1	RGD	RGD:1309444
Macaca mulatta	BICD1	VGNC	VGNC:70249
Felis catus	BICD1	VGNC	VGNC:83508
Canis familiaris	BICD1	VGNC	VGNC:38450

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

BICD1 - BICD cargo adaptor 1 Gene

关于 BICD1

功能概要

BICD1 基因产物(34)

BICD1 蛋白结构

BICD1 蛋白互作信息

关联疾病

直系同源

热门区域

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BICD1 - BICD cargo adaptor 1 Gene

关于 BICD1

功能概要

BICD1 基因产物(34)

BICD1 蛋白结构

BICD1 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z