1. Gene
  2. CCL21 - C-C motif chemokine ligand 21 Gene

CCL21 - C-C motif chemokine ligand 21 Gene

中文名称:CC 基序趋化因子配体 21

种属: Homo sapiens

同用名: ECL; SLC; CKb9; TCA4; 6Ckine; SCYA21

基因 ID: 6366 | 基因类型: protein coding

关于 CCL21

Cytogenetic location: 9p13.3 Genomic coordinates (GRCh38): 9:34,709,005-34,710,136 (from NCBI)

This gene has 2 transcripts (splice variants), 129 orthologues and 25 paralogues. Biased expression in lymph node (RPKM 1020.3), spleen (RPKM 170.8) and 2 other tissues.

功能概要

这种抗菌基因是聚集在 9 号染色体 p 臂上的几个 CC 细胞因子基因之一。细胞因子是一个参与免疫调节和炎症过程的分泌蛋白家族。 CC 细胞因子是以两个相邻的半胱氨酸为特征的蛋白质。与其他趋化因子类似,该基因编码的蛋白质可抑制造血并刺激趋化性。这种蛋白质在体外对胸腺细胞和活化的 T 细胞具有趋化性,但对 B 细胞、巨噬细胞或中性粒细胞没有趋化性。由该基因编码的细胞因子也可能在介导淋巴细胞归巢至次级淋巴器官中发挥作用。它是在 T 和 B 淋巴细胞上表达的趋化因子受体 7 的高亲和力功能性配体,也是细胞因子家族另一个成员 (小的可诱导细胞因子 A19) 的已知受体。[RefSeq 提供,2014 年 9 月]

This antimicrobial gene is one of several CC cytokine genes clustered on the p-arm of chromosome 9. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. Similar to Other chemokines the protein encoded by this gene inhibits hemopoiesis and stimulates chemotaxis. This protein is chemotactic in vitro for thymocytes and activated T cells, but not for B cells, macrophages, or neutrophils. The cytokine encoded by this gene may also play a role in mediating homing of lymphocytes to secondary lymphoid organs. It is a high affinity functional ligand for Chemokine Receptor 7 that is expressed on T and B lymphocytes and a known receptor for another member of the cytokine family (small inducible cytokine A19). [provided by RefSeq, Sep 2014]

CCL21 基因产物(1)

mRNA Protein Name
NM_002989.4 NP_002980.1 C-C motif chemokine 21 precursor
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables chemokine activity IDA
IDA: 通过直接分析推断
15778365 GOA
enables chemokine receptor binding IDA
IDA: 通过直接分析推断
23341447 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
14978162 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in G protein-coupled receptor signaling pathway IDA
IDA: 通过直接分析推断
18308860 GOA
involved in antimicrobial humoral immune response mediated by antimicrobial peptide IDA
IDA: 通过直接分析推断
12949249 GOA
involved in cell chemotaxis IDA
IDA: 通过直接分析推断
18308860 GOA
involved in dendritic cell chemotaxis IDA
IDA: 通过直接分析推断
15778365 GOA
involved in establishment of T cell polarity IDA
IDA: 通过直接分析推断
12729902 GOA
involved in killing of cells of another organism IDA
IDA: 通过直接分析推断
12949249 GOA
involved in mesangial cell-matrix adhesion IDA
IDA: 通过直接分析推断
15569314 GOA
involved in negative regulation of dendritic cell apoptotic process IDA
IDA: 通过直接分析推断
15059845 GOA
involved in negative regulation of leukocyte tethering or rolling IDA
IDA: 通过直接分析推断
18308860 GOA
involved in positive regulation of ERK1 and ERK2 cascade IDA
IDA: 通过直接分析推断
12729902 GOA
involved in positive regulation of JNK cascade IDA
IDA: 通过直接分析推断
15778365 GOA
acts upstream of or within positive regulation of T cell migration IDA
IDA: 通过直接分析推断
23620790 GOA
involved in positive regulation of actin filament polymerization IDA
IDA: 通过直接分析推断
11242036 GOA
involved in positive regulation of canonical NF-kappaB signal transduction IDA
IDA: 通过直接分析推断
15059845 GOA
involved in positive regulation of cell adhesion mediated by integrin IDA
IDA: 通过直接分析推断
15569314 GOA
involved in positive regulation of cell motility IDA
IDA: 通过直接分析推断
15778365 GOA
involved in positive regulation of cell-matrix adhesion IDA
IDA: 通过直接分析推断
15569314 GOA
involved in positive regulation of filopodium assembly IDA
IDA: 通过直接分析推断
15569314 GOA
involved in positive regulation of myeloid dendritic cell chemotaxis IDA
IDA: 通过直接分析推断
14592837 GOA
involved in positive regulation of neutrophil chemotaxis IDA
IDA: 通过直接分析推断
21051556 GOA
involved in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IDA
IDA: 通过直接分析推断
15059845 GOA
involved in positive regulation of pseudopodium assembly IDA
IDA: 通过直接分析推断
11242036 GOA
involved in release of sequestered calcium ion into cytosol IDA
IDA: 通过直接分析推断
14592837 GOA
involved in response to prostaglandin E IDA
IDA: 通过直接分析推断
14592837 GOA
involved in ruffle organization IDA
IDA: 通过直接分析推断
15569314 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

CCL21 蛋白结构

IL8

IL8: Small cytokines (intecrine/chemokine), interleukin-8 like (29 - 90)

  • 0
  • 100
  • 134 a.a.
蛋白主名 其他名称

C-C motif chemokine 21

Efficient Chemoattractant for Lymphocytes

CCL21 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
CCL21 O00585 TTMP Homo sapiens Q5BVD1 32296183
种属内
CCL21 O00585 JPH3 Homo sapiens Q8WXH2 32814053
种属内
CCL21 O00585 JPH3 Homo sapiens Q8WXH2 32814053
种属内
CCL21 O00585 JPH3 Homo sapiens Q8WXH2 32814053
种属内
CCL21 O00585 PF4V1 Homo sapiens P10720 28381538
种属内
CCL21 O00585 TMEM107 Homo sapiens Q6UX40 32296183
种属内
CCL21 O00585 OTP Homo sapiens Q5XKR4 32296183
种属内
CCL21 O00585 OTP Homo sapiens Q5XKR4 32296183
种属内
CCL21 O00585 OTP Homo sapiens Q5XKR4 32296183
种属内
CCL21 O00585 CCL17 Homo sapiens Q92583
SPR
28381538
种属内
CCL21 O00585 PF4 Homo sapiens P02776
SPR
28381538
种属内
CCL21 O00585 CXCL14 Homo sapiens O95715 28381538
种属内
CCL21 O00585 CCL5 Homo sapiens P13501 28381538
种属内
CCL21 O00585 CCL5 Homo sapiens P13501
SPR
28381538
种属内
CCL21 O00585 CXCL9 Homo sapiens Q07325 28381538
种属内
CCL21 O00585 CXCL12 Homo sapiens P48061
SPR
28381538
种属内
CCL21 O00585 CXCL12 Homo sapiens P48061 28381538
种属内
CCL21 O00585 CCL28 Homo sapiens Q9NRJ3 28381538
种属内
CCL21 O00585 CCL26 Homo sapiens Q9Y258 28381538
种属内
CCL21 O00585 CXCL10 Homo sapiens P02778 28381538
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 CCL21 蛋白

目录号 产品名 蛋白编号 纯度
HY-P7166 Exodus-2/CCL21 Protein, Human O00585 (S24-P134) ≥95%
HY-P72875 Exodus-2/CCL21 Protein, Human (sf9) O00585 (S24-P134) ≥95%

CCL21 抗体

目录号 产品名 应用 反应物种
HY-P83030 CCL21 Antibody (YA2775) WB Human

关联疾病

疾病名称 别名
Periapical Periodontitis

Apical Periodontitis

Periodontitis Apical

Primary Central Nervous System Lymphoma

Pcnsl

Primary Cns Lymphoma

Primary Brain Lymphoma

Primary Lymphoma, Cns

Primary Cerebral Lymphoma

Scrapie
Autoimmune Disease

Autoimmune Diseases

Autoimmune Hypersensitivity Disease

Hypersensitivity Reaction Type Ii Disease

Type Ii Hypersensitivity Reaction Disease

Sjogren Syndrome

Sicca Syndrome

Sjogren'S Syndrome

Sjögren Syndrome

Sjogren-Gougerot Syndrome

Keratoconjunctivitis Sicca

Sjögren'S Syndrome

Xerodermosteosis

Dacryosialoadenopathia Atrophicans

Gougerot-Houwer-Sjogren Syndrome

Gougerot-Sjogren Syndrome

Keratoconjunctivitis Sicca-Xerostomia

Secreto-Inhibitor-Xerodermostenosis

Primary Sjogren Syndrome

Primary Sjogren-Gougerot Syndrome

Sjogrens Syndrome Primary

Sjogrens Syndrome

Dry Eye Syndromes

Multiple Sclerosis

MS

Multiple Sclerosis, Susceptibility To

Disseminated Sclerosis

Multiple Sclerosis, Disease Progression, Modifier Of

Insular Sclerosis

Multiple Sclerosis Modifier Of Disease Progression

Multiple Sclerosis, Susceptibility To 1

Multiple Sclerosis, Susceptibility To, 1

Multiple Sclerosis 1

Generalized Multiple Sclerosis

Multiple Sclerosis Variant

Multiple Sclerosis Susceptibility To

Cerebrospinal Sclerosis

Generalised Multiple Sclerosis

Ms - [Multiple Sclerosis]

Disseminated Cerebrospinal Sclerosis

Disseminated Multiple Sclerosis

Disseminated Nervous System Myelosclerosis

Multiple Cerebrospinal Sclerosis

Multiple Combined Sclerosis

Multiple Sclerosis Generalised

Disseminated Brain Sclerosis

Disseminated Spinal Sclerosis

Insular Brain Sclerosis

Miliary Brain Sclerosis

Multiple Combined Sclerosis Of Spinal Cord

Multiple Ascending Sclerosis

Multiple Brain Sclerosis

Multiple Sclerosis Of Brain Stem

Multiple Sclerosis Of The Brain Stem

Multiple Sclerosis Of Cord

Sclérose En Plaques

Plaque Sclerosis

Multiple Sclerosis Of The Spinal Cord

Common Variable Immunodeficiency

Cvid

Common Variable Agammaglobulinemia

Common Variable Immune Deficiency

Acquired Hypogammaglobulinemia

Hypogamma-Globulinemia, Acquired

Idiopathic Immunoglobulin Deficiency

Primary Antibody Deficiency

Primary Hypogammaglobulinemia

Acquired Agammaglobulinemia

Sporadic Hypogammaglobulinemia

Common Variable Hypogamma-Globulinemia

Immunoglobulin Deficiency, Late-Onset

Common Variable Hypogammaglobulinemia

Immunodeficiency, Common Variable

Immune Deficiency Disease

Immunodeficiency

Primary Immunodeficiency

Primary Immunodeficiency Disease

Immunologic Deficiency Syndromes

Hypoimmunity

Immune Deficiency Disorder

Immunodeficiency Syndrome

Immune Disorder

Primary Immune Deficiency Disorder

Immune System Diseases

Human Immunodeficiency Virus Infection

Hiv - [Human Immunodeficiency Virus Infection]

Hiv Positive Nos

Hiv Disease

Acquired Immune Deficiency Syndrome-Related Complex

Aids-Like Syndrome

Aids-Related Complex Nos

Arc - [Aids-Related Complex]

Immunodeficiency Due To Human Immunodeficiency Virus Infection

Unspecified Human Immunodeficiency Virus Disease

Hiv Disease Nos

Human Immunodeficiency Virus Positive Nos

Hiv Nos

Deficiency Of Complement Initial Pathway

Deficiency Of Complement Terminal Pathway

Cfdd - [Complement Factor D Deficiency]

Immunodeficiency With Nk-Cell - [Natural-Killer Cell] Deficiency

Nonfamilial Hypogammaglobulinaemia

Common Variable Immune Deficiency

Nonfamilial Agammaglobulinaemia

Common Variable Agammaglobulinaemia

Agammaglobulinaemia Nos

Agammaglobulinaemia Antibody Deficiency Syndrome

Hypogammaglobulinaemia Antibody Deficiency Syndrome

Acquired Agammaglobulinaemia Nos

Hypogammaglobulinaemia Nos

Hyper Igm

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Bos taurus CCL21 VGNC VGNC:26948
Macaca mulatta CCL21 VGNC VGNC:104885
Felis catus CCL21 VGNC VGNC:60543
Rattus norvegicus CCL21 RGD RGD:1311996
Mus musculus CCL21 NCBI
Others CCL21 NCBI