2. Gene
  3. CXCL6 - C-X-C motif chemokine ligand 6 Gene

CXCL6 - C-X-C motif chemokine ligand 6 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：CXC 基序趋化因子配体 6

种属: Homo sapiens

同用名: GCP2; CKA-3; GCP-2; SCYB6

基因 ID: 6372 | 基因类型: protein coding

关于 CXCL6

Cytogenetic location: 4q13.3 Genomic coordinates (GRCh38): 4:73,836,678-73,838,760 (from NCBI)

This gene has 3 transcripts (splice variants), 75 orthologues and 12 paralogues. Biased expression in spleen (RPKM 44.2), gall bladder (RPKM 20.7) and 4 other tissues.

功能概要

该基因编码的蛋白质是 CXC 趋化因子家族的成员。编码的蛋白质对中性粒细胞具有趋化作用，对革兰氏阴性菌和革兰氏阳性菌具有抗菌作用。该基因和 CXC 趋化因子基因家族的其他成员在染色体 4q 区域形成一个基因簇。[RefSeq 提供，2020 年 6 月]

The protein encoded by this gene is a member CXC chemokine family. The encoded protein is a chemotactic for neutrophil granulocytes and has Antibacterial action against gram-negative and gram-positive bacteria. This gene and Other members of the CXC chemokine gene family form a gene cluster in a region of chromosome 4q. [provided by RefSeq, Jun 2020]

CXCL6 基因产物(1)

mRNA Protein Name
NM_002993.4 NP_002984.1 C-X-C motif chemokine 6 precursor
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables chemokine activity IDA
IDA: 通过直接分析推断
8399143 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
28381538 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in antimicrobial humoral immune response mediated by antimicrobial peptide IDA
IDA: 通过直接分析推断
8399143 GOA
involved in cellular response to lipopolysaccharide IDA
IDA: 通过直接分析推断
8399143 GOA
involved in neutrophil activation IDA
IDA: 通过直接分析推断
8399143 GOA
involved in neutrophil chemotaxis IDA
IDA: 通过直接分析推断
8399143 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

CXCL6 蛋白结构

IL8

IL8: Small cytokines (intecrine/chemokine), interleukin-8 like (49 - 106)

  • 0
  • 100
  • 114 a.a.
蛋白主名 其他名称

C-X-C motif chemokine 6

chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2)

CXCL6 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
CXCL6 P80162 PF4 Homo sapiens P02776
SPR
28381538
种属内
CXCL6 P80162 CCL5 Homo sapiens P13501
SPR
28381538
种属内
CXCL6 P80162 CXCL12 Homo sapiens P48061
SPR
28381538
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 CXCL6 蛋白

目录号 产品名 蛋白编号 纯度
HY-P72677 GCP-2/CXCL6 Protein, Human (HEK293, His) P80162 (G38-N114) ≥95%
HY-P700048AF Animal-Free GCP-2/CXCL6 Protein, Human (His) P80162 (V40-N114) ≥95%

关联疾病

疾病名称 别名
Tonsillitis

Chronic Tonsillitis

Throat Infection - Tonsillitis
Mastitis

Breast Inflammation

Inflammatory Breast Disease

Inflammatory Disease Of Breast

Inflammation Of Non-Human Mammary Gland

Inflammatory Disorder Of Breast

Mastitis Nos

Acute Mastitis Nos

Acute Nonpuerperal Mastitis

Nonpuerperal Mastitis Nos

Subacute Mastitis Nos
Sodoku Disease

Spirillosis

Sodoku

Spirillary Fever

Rat-Bite Fever

Rat-Bite Fever Due To Spirillum Minus

Spirillary Rat-Bite Fever

Sokosho
Gastroduodenitis
Hyperinsulinemic Hypoglycemia, Familial, 5

Hyperinsulinism Due To Insr Deficiency

HHF5

Familial Hyperinsulinemic Hypoglycemia 5

Hyperinsulinemic Hypoglycemia Due To Insr Deficiency

Hyperinsulinemic Hypoglycemia Due To Insulin Receptor Deficiency

Congenital Hyperinsulinism

Persistent Hyperinsulinemic Hypoglycemia Of Infancy

Phhi

Hyperinsulinemic Hypoglycemia Familial 5
Lung Disease

Lung Diseases

Disorder Of Lung

Abnormality Of The Lung
Inflammatory Bowel Disease

Inflammatory Bowel Diseases

Bowel Disease, Inflammatory
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS03394 CXCL6 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus CXCL6 RGD RGD:708540
Mus musculus CXCL6 MGD MGI:1096868
Macaca mulatta CXCL6 VGNC VGNC:106565
Others CXCL6 NCBI
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