1. Gene
  2. CXCL5 - C-X-C motif chemokine ligand 5 Gene

CXCL5 - C-X-C motif chemokine ligand 5 Gene

中文名称:CXC 基序趋化因子配体 5

种属: Homo sapiens

同用名: SCYB5; ENA-78

基因 ID: 6374 | 基因类型: protein coding

关于 CXCL5

Cytogenetic location: 4q13.3 Genomic coordinates (GRCh38): 4:73,995,642-73,998,677 (from NCBI)

This gene has 1 transcript (splice variant), 32 orthologues and 12 paralogues. Biased expression in appendix (RPKM 23.4), urinary bladder (RPKM 8.7) and 5 other tissues.

功能概要

该基因编码的蛋白质是趋化因子 CXC 亚家族的成员。募集和激活白细胞的趋化因子按功能 (炎症或稳态) 或结构分类。该蛋白被提议结合 G 蛋白偶联受体趋化因子 (CXC 基序) 受体 2 以募集中性粒细胞,促进血管生成和重塑结缔组织。这种蛋白质被认为在癌细胞增殖、迁移和侵袭中发挥作用。[RefSeq 提供,2013 年 5 月]

This gene encodes a protein that is a member of the CXC subfamily of chemokines. Chemokines, which recruit and activate leukocytes, are classified by function (inflammatory or homeostatic) or by structure. This protein is proposed to bind the G-protein coupled receptor chemokine (C-X-C motif) receptor 2 to recruit neutrophils, to promote angiogenesis and to remodel connective tissues. This protein is thought to play a role in Cancer cell proliferation, migration, and invasion. [provided by RefSeq, May 2013]

CXCL5 基因产物(1)

mRNA Protein Name
NM_002994.5 NP_002985.1 C-X-C motif chemokine 5 precursor
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables identical protein binding IDA
IDA: 通过直接分析推断
24695525 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
32296183 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

CXCL5 蛋白结构

IL8

IL8: Small cytokines (intecrine/chemokine), interleukin-8 like (49 - 106)

  • 0
  • 100
  • 114 a.a.
蛋白主名 其他名称

C-X-C motif chemokine 5

chemokine (C-X-C motif) ligand 5

CXCL5 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
CXCL5 P42830 MEOX2 Homo sapiens Q6FHY5
Y2H Prey Pooling
32296183
种属内
CXCL5 P42830 MEOX2 Homo sapiens Q6FHY5
Validated Y2H
32296183
种属内
CXCL5 P42830 MEOX2 Homo sapiens Q6FHY5
Y2H Array
32296183
种属内
CXCL5 P42830 ACTN3 Homo sapiens Q08043
Validated Y2H
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 CXCL5 蛋白

目录号 产品名 蛋白编号 纯度
HY-P7157 ENA-78/CXCL5 Protein, Human (HEK293) P42830 (A37-N114) ≥95%
HY-P7158 ENA-78/CXCL5 Protein, Human P42830 (R45-N114) ≥95%
HY-P700047AF Animal-Free ENA-78/CXCL5 Protein, Human (His) P42830 (R45-N114) ≥95%

关联疾病

疾病名称 别名
Pulmonary Sarcoidosis

Sarcoidosis, Pulmonary

Lung Sarcoidosis

Sarcoidosis Pulmonary

Lung Sarcoid

Sarcoidosis In Lung

Extrinsic Allergic Alveolitis

Hypersensitivity Pneumonitis

Alveolitis, Extrinsic Allergic

Alveolitis

Allergic Interstitial Pneumonitis

Allergic Pneumonitis

Extrinsic Allergic Pneumonia Hypersensitivity Pneumonitis

Hp

Pneumonitis Hypersensitivity

Allergic Alveolitis

Extrinsic Allergic Alveolitis Nos

Airway Obstruction With Allergic Alveolitis

Unspecified Allergic Alveolitis And Pneumonitis

Extrinsic Allergic Bronchiolo-Alveolitis

Hypersensitivity Pneumonia

Hypersensitivity Pneumonitis Nos

Obstructive Lung Disease With Allergic Alveolitis

Obstructive Lung Disorder With Hypersensitivity Pneumonitis

Obstructive Lung Disorder With Allergic Alveolitis

Obstructive Lung Disease With Hypersensitivity Pneumonitis

Gastritis

Acute Gastric Mucosal Erosion

Erosive Gastritis

Erosive Gastropathy

Gastritis Erosive

Idiopathic Erosive/Hemorrhagic Gastritis

Inflammation Of Gastric Mucosa

Gastroduodenitis

Gastritis Nos

Noninfectious Gastroenteritis

Nonbacterial Gastroenteritis Of Infant

Acute Gastric Infection

Acute Simple Gastritis

Chronic Antral Gastritis

Chronic Fundal Gastritis

Chronic Simple Gastritis

Acute Gastroduodenitis

Acute Antral Gastritis

Acute Erosive Gastritis

Bile Reflux Gastritis

Gastritis Due To Biliary Reflux

Interstitial Lung Disease 2

Idiopathic Pulmonary Fibrosis

Ipf

Fibrocystic Pulmonary Dysplasia

Pulmonary Fibrosis, Idiopathic

Pulmonary Fibrosis, Idiopathic, Susceptibility To

Cryptogenic Fibrosing Alveolitis

ILD2

Idiopathic Pulmonary Fibrosis, Familial

Fibrosing Alveolitis, Cryptogenic

Uip

Fibrosing Alveolitis

Interstitial Pneumonitis, Usual

Familial Idiopathic Pulmonary Fibrosis

Idiopathic Fibrosing Alveolitis, Chronic Form

Usual Interstitial Pneumonia

Fibrosing Alveolitis Cryptogenic

Hamman-Rich Disease

Idiopathic Pulmonary Fibrosis Familial

Interstitial Pneumonitis Usual

Fibrosis Idiopathic Pulmonary

Fibrosis, Pulmonary, Idiopathic

Hamman-Rich Syndrome

Chronic Idiopathic Pulmonary Fibrosis

Acute Interstitial Pneumonia

Interstitial Pulmonary Fibrosis

Ipf - [Idiopathic Pulmonary Fibrosis]

Idiopathic Lung Fibrosis

Fibrosing Lung Disease

Pulmonary Fibrosis Nos

Fibrosing Pneumonitis

Hyper Ige Syndrome

Hyper-Ige Syndrome

Hyper Immunoglobulin E Syndrome

Hies

Hyper-Ige Recurrent Infection Syndrome

Hyperimmunoglobulin E Syndrome

Hyper Ige

Job Syndrome

Hartnup Disease

Endometriosis

Endometriosis, Site Unspecified

Endometrial Ectopia

Bacterial Meningitis

Meningitis, Bacterial

Meningitis Bacterial

Bm - [Bacterial Meningitis]

Leptomeningitis Bacterial

Pachymeningitis Bacterial

Arachnoiditis Bacterial

Pneumonia

Acute Pneumonia

Pneumonias

Infectious Pneumonia

Pn - [Pneumonia]

Lobar Pneumonia Nos

Multifocal Pneumonia

Orthostatic Pneumonia

Pneumonia Nos

Chronic Pneumonia Nos

Atypical Pneumonia

Passive Pneumonia

Purulent Pneumonia

Interstitial Lobar Pneumonia

Pneumonia, Unspecified

Pneumonia Due To Chlamydia

Pneumonia Due To Chlamydia Pneumoniae

Pneumonia Due To E. Coli

Escherichia Coli Lobar Pneumonia

Pneumonia Due To H. Influenzae

Pneumonia Due To Hemophilus Influenzae

Bronchopneumonia Due To H. Influenzae

Haemophilus Influenzae Lobar Pneumonia

Bronchopneumonia Due To Hemophilus Influenzae

Pseudomonal Pneumonia

Pseudomonas Pneumonia

Pseudomonas Lobar Pneumonia

Staphylococcal Pneumonia

Staphylococcus Pneumonia

Acute Staphylococcal Pneumonia

Staphylococcal Double Pneumonia

Staphylococcal Lobar Pneumonia

Staphylococcal Purulent Pneumonia

Staphylococcal Bronchopneumonia

Pneumococcal Pneumonia

Pneumococcus Pneumonia

Bronchopneumonia Due To S. Pneumoniae

Pneumococcal Lobar Pneumonia

Streptococcal Pneumoniae Pneumonia

Streptococcus Pneumoniae Lobar Pneumonia

Pyemic Pneumococcal Embolism With Pneumonia

Bronchopneumonia Due To Streptococcus Pneumoniae

Pneumonia Due To Streptococcus, Group B

Group B Streptococcal Pneumonia

Adenovirus Pneumonia

Adenoviral Pneumonia

Adenovirus Viral Pneumonia

Pneumonia Respiratory Syncytial Viral

Parainfluenza Viral Pneumonia

Parainfluenzal Pneumonia

Parainfluenza Virus Pneumonia

Human Metapneumovirus Pneumonia

Human Metapneumovirus Infection Resulting In Pneumonia

Pneumocystis Pneumonia

Plasma Cells Pneumonia

Rheumatoid Arthritis

RA

Arthritis, Rheumatoid

Rheumatoid Arthritis, Susceptibility To

Arthritis Or Polyarthritis, Rheumatic

Atrophic Arthritis

Rheumatism Arthritis

Rheumatoid Polyarthritis

Inflammatory Bowel Disease

Inflammatory Bowel Diseases

Bowel Disease, Inflammatory

Sarcoidosis 1

Sarcoidosis

Boeck Sarcoid

Besnier-Boeck-Schaumann Disease

SS1

Sarcoidosis, Susceptibility To, 1

Lymphogranulomatosis

Hodgkin Disease

Boeck'S Disease

Boeck'S Sarcoid

Schaumann'S Disease Or Syndrome

Hutchinson-Boeck Disease Or Syndrome

Asymptomatic Neurosyphilis

Neurosyphilis

Neurosyphilis, Asymptomatic

Asthma

Chronic Obstructive Asthma

Asthma, Diminished Response To Antileukotriene Treatment In

Bronchial Hyperreactivity

Asthma, Susceptibility To

Asthma, Bronchial

Asthma, Protection Against

Asthma, Nocturnal, Susceptibility To

Nocturnal Asthma

Asthma-Related Traits

Asthma-Related Traits, Susceptibility To

Asthma, Nocturnal

Chronic Obstructive Asthma With Acute Exacerbation

Chronic Obstructive Asthma With Status Asthmaticus

Exercise Induced Asthma

Exercise-Induced Asthma

Bronchial Asthma

Asthma, Exercise-Induced

Idiosyncratic Asthma

Unspecified Asthma With Acute Exacerbation

Asthma, Unspecified, With Stated Status Asthmaticus

Status Asthmaticus Nos

Acute Severe Asthma

Acute Severe Bronchial Asthma

Status Asthma

Status Post Asthmaticus

Colorectal Cancer

Colon Cancer

Colorectal Carcinoma

Colon Carcinoma

Colorectal Cancer, Susceptibility To

Carcinoma Of Colon

CRC

Colorectal Cancer With Chromosomal Instability, Somatic

Colon Cancer, Somatic

Colon Cancer, Susceptibility To

Colonic Neoplasms

Colorectal Neoplasms

Colorectal Cancer, Somatic

Colon Cancer, Advanced, Somatic

Colonic Carcinoma

Colorectal Carcinomas

Colon Cancers

Colorectal Cancers

Cancer, Colorectal, Somatic

Cancer, Colon

Cancer, Colorectal, Susceptibility To

Colorectal Neoplasm

Colonic Neoplasm

Malignant Tumor Of Colon

Chronic Congestive Splenomegaly
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Mus musculus CXCL5 MGD MGI:1096868
Others CXCL5 NCBI