2. Gene
  3. Mmp8 - matrix metallopeptidase 8 Gene

Mmp8 - matrix metallopeptidase 8 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：基质金属肽酶 8

种属: Rattus norvegicus

基因 ID: 63849 | 基因类型: protein coding

关于 Mmp8

Primary_assembly 8: 4,724,029-4,733,520 forward strand.mRatBN7.2:CM026981.1

This gene has 1 transcript (splice variant), 111 orthologues, 23 paralogues and is associated with 19 phenotypes. Biased expression in Spleen (RPKM 36.6), Lung (RPKM 21.7) and 4 other tissues.

功能概要

该基因编码的蛋白可启动钙离子结合活性；金属肽酶活性；和锌离子结合活性。参与多个过程，包括神经炎症反应的正调节；一氧化氮生物合成过程的正调控；和肿瘤坏死因子产生的正调节。位于细胞外空间。充血性心力衰竭的生物标志物。该基因的人类直系同源物与乳腺癌和颈动脉疾病有关。与人 MMP8（基质金属肽酶 8）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables calcium ion binding activity; metallopeptidase activity; and zinc ion binding activity. Involved in several processes, including positive regulation of neuroinflammatory response; positive regulation of nitric oxide biosynthetic process; and positive regulation of tumor necrosis factor production. Located in extracellular space. Biomarker of congestive heart failure. Human ortholog(s) of this gene implicated in breast Cancer and carotid artery disease. Orthologous to human MMP8 (matrix metallopeptidase 8). [provided by Alliance of Genome Resources, Apr 2022]

Mmp8 基因产物(1)

mRNA Protein Name
NM_022221.2 NP_071557.2 neutrophil collagenase preproprotein
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables calcium ion binding IMP
IMP: 通过突变表型推断
16153442 RGD
enables endopeptidase activity IMP
IMP: 通过突变表型推断
25049354 RGD
enables metallopeptidase activity IDA
IDA: 通过直接分析推断
16153442 RGD
enables zinc ion binding IMP
IMP: 通过突变表型推断
16153442 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cellular response to lipopolysaccharide IMP
IMP: 通过突变表型推断
25049354 RGD
involved in ossification IEP
IEP: 通过表达模式推断
15052653 RGD
involved in positive regulation of neuroinflammatory response IMP
IMP: 通过突变表型推断
25049354 RGD
involved in positive regulation of tumor necrosis factor production IMP
IMP: 通过突变表型推断
25049354 RGD
involved in protein catabolic process IDA
IDA: 通过直接分析推断
16153442 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in extracellular space IDA
IDA: 通过直接分析推断
16940237 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

neutrophil collagenase

MMP-8

matrix metalloproteinase-8

neutrophil collagenease

相关产品

Clinical Phase
生物活性分子 (2)
目录号 产品名 作用方式
纯度 Phase
HY-19485 XL-784 Inhibitor 98.13% Phase 2
HY-112160 XL-784 free base Inhibitor / Phase 2
Pre-clinical Phase
生物活性分子 (23)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-148905 p-Aminophenylmercuric acetate Activator 99.07% 否
HY-113952 Actinonin 98.61% 否
HY-110397 KP-457 Inhibitor 99.18% 否
HY-N1463 Luteolin 7-O-glucuronide Inhibitor 99.80% 否
HY-P4931 Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 99.87% 否
HY-N1454 Apigenin-7-glucuronide Inhibitor 99.73% 否
HY-114091 PF-00356231 hydrochloride Inhibitor 99.52% 否
HY-128133 MMP-8 inhibitor-1 Inhibitor ≥98.0% 否
HY-107639 UK-370106 Inhibitor ≥99.0% 否
HY-147745 MMP2-IN-2 Inhibitor 98.80% 否
HY-147746 MMP2-IN-3 Inhibitor 99.64% 否
HY-110116 SD-2590 hydrochloride Inhibitor 99.1% 否
HY-110397G KP-457 (GMP) Inhibitor / 否
HY-114091A PF-00356231 Inhibitor / 否
HY-137793 Pro-Leu-Gly-NHOH hydrochloride Inhibitor / 否
HY-162038 RXP03 Inhibitor / 否
HY-168605 DH-18 / 否
HY-P2682 MMP-8/MMP-26 Fluorogenic substrate / 否
HY-RS08554 MMP8 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS08555 Mmp8 Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS08556 Mmp8 Rat Pre-designed siRNA Set A Pre-designed Sets / 否
HY-114396 BR351 Inhibitor / 否
HY-43586 BR351 precursor Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Mmp8 NCBI NCBI:4317
Macaca fascicularis Mmp8 NCBI NCBI:102141209
Mus musculus Mmp8 NCBI NCBI:17394
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z